Am J Transplant, Volume 22, Suppl 3 Archives - Page 24 of 190 - ATC Abstracts

2022 American Transplant Congress
The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice
D. R. Butcher, B. D. Thompson, H. K. Singh, V. Nickeleit
Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC
*Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…
2022 American Transplant Congress
CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
K. J. Dery¹, H. Kojima¹, K. Kadono², H. Hirao¹, J. Kupiec-Weglinski³
¹UCLA, Los Angeles, CA, ²Liver Transplant Surgery, UCLA, Los Angeles, CA, ³UCLA Medical Center, Los Angeles, CA
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
2022 American Transplant Congress
Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants
B. Keating¹, B. Piening², M. Mangiola³, J. Stern⁴, W. Zhang⁵, A. Griesemer⁶, B. Lonze⁷, M. Snyder⁸, J. Boeke⁵, R. Montgomery⁷
¹University of Pennsylvania, Philadelphia, PA, ²Providence Cancer Center, Portland, OR, ³New York University Langone Medical Center, New York, NY, ⁴Department of Surgery, NYU Langone, New York, NY, ⁵Institute of Systems Genetics, NYU Langone, New York, NY, ⁶Surgery, NYU Langone, New York, NY, ⁷NYU Langone Transplant Institute, New York, NY, ⁸Genetics, Stanford, Palo Alto, CA
*Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
2022 American Transplant Congress
Impact of Recipient Warm Ischemic Time on Outcomes Associated with High KDPI and DCD Donor Kidneys: Cold Ischemic Time Remains Paramount
M. L. Jacobs, R. Stratta, M. Garner, B. Sharda, A. Farney, G. Orlando, A. Reeves-Daniel, C. Jay
Department of Surgery, Atrium Health Wake Forest Baptist, Winston Salem, NC
*Purpose: Previously we demonstrated that cold ischemic time (CIT) beyond 24 hours was an important risk predictor of early graft loss (EGL) and primary non-function…
2022 American Transplant Congress
Use of New 2021 CKD-EPI as an Endpoint in Transplant Trials May Significantly Influence Observations
E. Yanqui¹, H. Hames¹, T. Shi², A. R. Shields¹, E. S. Woodle¹, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²CCHMC, Cincinnati, OH
*Purpose: GFR equations have recently been modified primarily to avoid disadvantaging black populations. The purpose of this study was to evaluate renal function and the…
2022 American Transplant Congress
Identifying Predictors of Pediatric Heart Only versus Combined Heart-Liver Transplantation
K. Zhang, S. Chen, A. Syed, A. Gallo, C. Esquivel, C. Bonham, S. Hollander, M. Ma, J. Han, N. Ebel
Stanford University, Stanford, CA
*Purpose: A standardized protocol to identify which patients with Fontan failure require combined heart liver transplant (cHLT) versus isolated heart transplant (HT) has not yet…
2022 American Transplant Congress
Adenovirus Enteritis Following Intestinal Transplantation
S. Jafri¹, A. Mavis², J. Weiner³, M. C. Segovia²
¹Henry Ford Health System, Detroit, MI, ²Duke University, Durham, NC, ³Columbia, New York, NY
*Purpose: Intestinal transplant is a life-saving therapy for intestinal failure. Adenovirus Enteritis (AE) is an unusual infection identified on biopsy or serology following intestine or…
2022 American Transplant Congress
Local Mesenchymal Stem Cell Therapy for the Ex Vivo Preservation of a Porcine Vascularized Composite Allograft with 24-hour Normothermic Machine Perfusion
A. Bernal¹, J. Hinshaw¹, J. Pena¹, C. Hinshaw¹, D. Wood¹, K. Zimmern², N. McMahon², J. Ling², W. Zhang¹, E. Weitzel¹
¹US Army Institute of Surgical Research/59th MDW, San Antonio, TX, ²Southwest Research Institute, San Antonio, TX
*Purpose: Given therapeutic limitations in limb salvage, we sought to demonstrate the efficacy of combining local mesenchymal stem cells (MSCs) infusion with fresh whole blood…
2022 American Transplant Congress
Deep Phenotyping Methods Highlight Recipient-Derived CD16+ NK and CD16+ Monocyte Infiltration During Kidney Transplant Rejection
B. Lamarthée¹, J. Callemeyn¹, P. Koshy², T. Debyser³, E. Van Loon¹, A. Franken⁴, T. Van Brussel⁴, I. Arijs⁴, D. Lambrechts⁴, A. Senev¹, T. Vaulet⁵, C. Tinel¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, ³Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁴Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ⁵ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: How the immune system participates to kidney transplant rejection has not been fully elucidated. Single-cell (sc) genomics techniques are revolutionizing our ability to characterize…
2022 American Transplant Congress
Bilateral Renal Autotransplantation for Retroperitoneal Liposarcoma
S. Nagaraju¹, T. Robinson², K. P. Samy², W. Goggins², L. Koniaris²
¹Renal Transplant, Charleston Area Medical Center, Charleston, WV, ²Surgery, Indiana University School of Medicine, Indianapolis, IN
*Purpose: We report the first case of bilateral renal autotransplantation after staged resection of a giant liposarcoma of the retroperitoneum.*Methods: A 39-year-old male presented with…