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American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions

    M. J. Ellis1, T. Maw2, E. Huang3, E. Stites4, F. Shihab5, D. C. Brennan6, G. Shekhtman7, N. Agrawal7, J. Zeng7, S. Kung8

    1Duke University, Durham, NC, 2University of Southern California, Los Angeles, CA, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4University of Colorado, Aurora, CO, 5University of Utah, Salt Lake City, UT, 6Johns Hopkins School of Medicine, Baltimore, MD, 7CareDx, Brisbane, CA, 8University of California, San Francisco, San Francisco, CA

    *Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
  • 2022 American Transplant Congress

    Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of T-cell Mediated Rejection in Kidney Transplant Biopsies

    D. Kumar1, I. Moinuddin1, L. Kamal1, M. Shinbashi1, N. Raju1, R. Minniti1, F. Moran1, P. Halloran2, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2University of Alberta, Edmonton, AB, Canada

    *Purpose: We have reported the correlation of donor-derived cell-free DNA (dd-cfDNA) with histologic and molecular diagnosis (MMDx) of kidney transplant biopsies (Gupta et al, Transplantation…
  • 2022 American Transplant Congress

    Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy

    S. P. Patel, F. Bartlett, T. Sprague, J. Newman, E. Andrade, N. Rao, N. Patel, D. Dubay, V. Rohan, M. Casey, D. Taber

    MUSC Health, Charleston, SC

    *Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…
  • 2022 American Transplant Congress

    Medical Necessity Kidney Donation in the Treatment Algorithm for Nutcracker Syndrome: Transforming Pain to Altruism

    N. Baker, J. Campsen, L. Aviles-Ovalle, M. Molnar, A. Jones, G. Rofaiel, R. Kim, T. Baker

    Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT

    *Purpose: Patients with nutcracker syndrome (NCS) are often presented with multiple treatment pathways, including interventional and surgical options. In those who elect native nephrectomy, consideration…
  • 2022 American Transplant Congress

    Identifying Health System-Level Barriers to Living Donor Kidney Transplantation: A Cross-Sectional Survey of Health Professionals

    S. Sandal1, I. Schiller1, N. Dendukuri1, J. Robert1, K. Katergi1, A. Alam1, M. Cantarovich1, J. F. Fiore Jr1, C. Weber1, M. Fortin2

    1McGill University, Montreal, QC, Canada, 2University of Montreal, Montreal, QC, Canada

    *Purpose: There is growing recognition that efforts to increase living donor kidney transplantation (LDKT) should focus on health system-level inefficiencies. While previous studies focused on…
  • 2022 American Transplant Congress

    Cold Pulsatile Perfusion of Donor Kidneys Varies Significantly by Procuring Organ Procurement Organization Indicating Both Over and Underutilization of This Preservation Method

    D. S. Keith, E. Lessmann

    Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL

    *Purpose: To assess the usage and variability cold pulsatile perfusion preservation in the United States based on procuring organ procurement organization (OPO).*Methods: All donors procured…
  • 2022 American Transplant Congress

    Faster B Cell Rebound is Observed Following Xenotransplantation Compared to Allotransplantation in a Highly Sensitized Nonhuman Primate Kidney Transplantation Model

    I. DeLaura, M. Manook, D. Olaso, J. Yoon, R. Baldi, S. Knechtle, J. Kwun

    Surgery, Duke Transplant Center, Durham, NC

    *Purpose: Xenotransplantation outcomes have been greatly improved due to the advent of genetically engineered pigs and agents targeting the CD40-CD40L signaling pathway. However, studies have…
  • 2022 American Transplant Congress

    Utilization of a Pharmacy Technician to Improve Immunization Rates for Pediatric Heart and Kidney Transplant Recipients

    A. Brewer1, E. Benefield1, S. Boehme1, B. Jensen1, K. Molina2, C. Peterson2, C. Heyrend1

    1Primary Children's Hospital, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT

    *Purpose: Transplant recipients are at increased risk of infectious complications from vaccine-preventable diseases. This study aimed to evaluate using a pharmacy technician to provide routine…
  • 2022 American Transplant Congress

    Distinct Phenotypes of Kidney Transplant Recipients with Delayed Graft Function Identified Through Machine Learning Consensus Clustering

    C. Jadlowiec1, C. Thongprayoon2, N. Leeaphorn3, W. Kaewput4, P. Pattharanitima5, M. Cooper6, W. Cheungpasitporn2

    1Division of Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ, 2Division of Nephrology and Hypertension, Mayo Clinic Rochester, Rochester, MN, 3Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO, 4Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand, 5Department of Internal Medicine, Thammasat University, Pathum Thani, Thailand, 6Medstar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC

    *Purpose: The significance of delayed graft function (DGF) and its impact on kidney transplant (KT) outcomes remains debated. We aimed to assess outcomes for KT…
  • 2022 American Transplant Congress

    Does Comprehensive Geriatric Assessment Impact Risk Assessment for Potential Kidney Transplant Patients?

    J. Patel1, S. Hussain2, D. Mills1, A. Edobor3, E. Walters3, J. Williams3, Y. Kyeso2, J. F. Fung3, R. Barth3, D. Rubin4, M. Huisingh-Scheetz2, M. Martinchek5, M. L. Madariaga3

    1Pritzker School of Medicine, University of Chicago, Chicago, IL, 2Medicine, University of Chicago Medicine, Chicago, IL, 3Surgery, University of Chicago Medicine, Chicago, IL, 4Anesthesia, University of Chicago Medicine, Chicago, IL, 5Medicine, Massachusetts General Hospital, Boston, MA

    *Purpose: The clinical impact of the components of a comprehensive geriatric assessment (CGA) on kidney transplant decision making in older adults has not been investigated.*Methods:…
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