2022 American Transplant Congress
Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…2022 American Transplant Congress
Donor-Derived Duodenal Adenocarcinoma of a Bladder-Drained Pancreas Allograft
*Purpose: Donor-derived malignancies are rare but frequently present with aggressive pathology and high mortality rates [PMID 32627325]. The urologic literature demonstrates an increased risk of…2022 American Transplant Congress
Characteristics and Outcomes of Patients Admitted for Acute Alcoholic Hepatitis Before and During the COVID-19 Pandemic
*Purpose: Despite known increases in alcohol use, changes in alcohol-associated liver disease rates during COVID-19 have not been well characterized. We compared the incidence and…2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…2022 American Transplant Congress
Impact of ATG Dose Reduction on Kidney Transplant Outcomes During the Covid-19 Pandemic
*Purpose: During the COVID-19 pandemic, many transplant centers modified induction immunosuppression regimens. Beginning December 2020, our center reduced anti-thymocyte globulin (ATG) protocol dosing by up…2022 American Transplant Congress
Programmatic Fidelity is Central to the Development of Virtual Living Donor Kidney Transplantation Educational Programs
University of Alabama at Birmingham, Birmingham, AL
*Purpose: The Living Donor Navigator program is designed to mitigate disparities in living donor kidney transplantation (LDKT), though geographic disparities in program participation were observed…2022 American Transplant Congress
Nonadherence Post-Kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay
*Purpose: Nonadherence to immunosuppressive medications is common post-transplantation. We hypothesized that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs), which may…2022 American Transplant Congress
Robotic-Assisted Reconstruction of the Transplant Ureter: A Minimally Invasive Option for a Rare Complication
*Purpose: Ureteric stricture are rare after kidney transplants but nonetheless this complication requires reconstruction in the majority of cases to avoid graft dysfunction and/or failure.…2022 American Transplant Congress
Defining the Longitudinal Dynamics of Immune Cells in Blood in the First Year After Pediatric Liver Transplantation (pLTx)
*Purpose: In the European multicentre “ChilSFree” study we aimed for a deep characterisation of the longitudinal immune dynamics during the first year after pLTx.*Methods: Absolute…2022 American Transplant Congress
PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance
Surgery, University of Wisconsin, Madison, WI
*Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…
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