ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Use of De Novo mTOR Inhibitors in Highly Sensitized Kidney Transplant Recipients

    J. Bastos1, T. Freesz2, C. Bisi3, C. Marinho2, A. Pires2, V. Colares3, R. Neto2, G. Ferreira2

    1Tranplant Unit, Santa Casa De Misericordia De Juiz de Fora, Juiz de Fora, Brazil, 2Transplant Unit, Santa Casa De Misericórdia De Juiz de Fora, Juiz de Fora, Brazil, 3Tranplant Unit, Santa Casa De Misericórdia De Juiz de Fora, Juiz de Fora, Brazil

    *Purpose: mTOR inhibitors (mTORi) allow calcineurin-inhibitor reduction without loss of efficacy and may improve allograft-transplant outcomes. However, the safety of this protocol in high-immunological risk…
  • 2022 American Transplant Congress

    Developing A Tool To Assess Psychosocial Determinants Of Health And Quality Of Life In Pediatric Liver Transplant Patients

    C. R. Christmann1, S. Rath2, S. Sakhuja3, N. Galvan2

    1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine, Houston, TX, 3Baylor College of Medicine, Sugar Land, TX

    *Purpose: Psychosocial assessment prior to liver transplantation is essential to ensure that caregivers and pediatric patients are adequately prepared for this complex process. There are…
  • 2022 American Transplant Congress

    Increased Risk for Allograft Loss in African American Kidney Transplant Recipients After Biopsy for Chronic Allograft Dysfunction

    C. R. Dorr1, B. Wu2, B. Guo2, W. Guan2, D. Schladt1, S. Elmer1, G. Crary3, G. Onyeaghala1, W. Oetting2, G. Agarwal4, R. B. Mannon5, P. Jacobson2, A. Matas2, A. Israni3

    1Hennepin Healthcare Research Institute, Minneapolis, MN, 2University of Minnesota, Minneapolis, MN, 3Hennepin County Medical Center, Minneapolis, MN, 4University of Alabama at Birmingham, Birmingham, AL, 5Medicine, University of Nebraska Medical Center, Omaha, NE

    *Purpose: Chronic allograft dysfunction (CGD) is the first sign of a “troubled kidney”. CGD was defined as >25% increase in serum creatinine relative to a…
  • 2022 American Transplant Congress

    Single Cell Transcriptomics Reveal Allograft Immune Cell Patterns Associated with Histological Features of Acute Cellular Rejection in Liver Transplantation

    L. Tran1, A. Zahorchak1, C. Macedo1, T. Tabib2, F. Lakkis3, A. Humar1, D. Metes1, A. Thomson1

    1Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, 2University of Pittsburgh Medical Center, Pittsburgh, PA, 3University of Pittsburgh Medical Center - Thomas E. Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Development of successful tolerance induction strategies using immune cell-based therapies in transplantation depends on improved understanding of the local intra-graft cellular milieu that underlies…
  • 2022 American Transplant Congress

    Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, Z. Stewart1, B. Lonze1, M. Mangiola1, C. DiMaggio1, E. Weldon1, I. Saeed1, J. Leonard1, R. Herati1, J. Thomas1, J. Michael1, C. Hickson1, K. Cartiera1, R. Montgomery1

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY

    *Purpose: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection after SARS-CoV-2 vaccination have…
  • 2022 American Transplant Congress

    Inflammation After Kidney Transplantation Is Associated With Overall- And Death-censored Graft Loss

    T. F. Heldal, T. Jenssen, A. Hartmann, K. Heldal, A. Asberg

    Department of Transplantational Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway

    *Purpose: Early graft loss after kidney transplantation (KT) is mainly a result of acute rejection, while long-term graft loss episodes are often dependent on multifactorial…
  • 2022 American Transplant Congress

    A Randomized Phase 2 Study Of Mau868 Vs Placebo To Treat Bk Viremia In Kidney Transplant Recipients

    S. Jordan1, A. P. Limaye2, B. Fischbach3, P. Sood4, S. Collette5, L. Gasink6, M. W. Fordyce7, C. J. Lin7, M. Hodges6, D. C. Brennan8

    1Cedars-Sinai Medical Center, Los Angeles, CA, 2University of Washington, Seattle, WA, 3Dallas Nephrology Associates, Inc, Dallas, TX, 4University of Pittsburgh Medical Center, Pittsburgh, PA, 5Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada, 6previous employee/consultant for Amplyx Pharmaceuticals, San Diego, CA, 7Vera Therapeutics, Inc, Brisbane, CA, 8Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: To assess the safety and efficacy of MAU868, a BK virus-specific monoclonal antibody, in adult kidney transplant recipients with BK viremia.*Methods: This is a…
  • 2022 American Transplant Congress

    Superoxide in Cardiac Allografts from Donors After Circulatory Death

    M. Urban1, T. Bruett2, K. F. Duncan1, N. W. Markin3, M. M. Chacon3, M. C. Zimmerman4

    1Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, 2College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, 3Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 4Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE

    *Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
  • 2022 American Transplant Congress

    Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture

    A. Asthana1, D. Chaimov1, R. Tamburrini2, S. J. Walker3, G. Orlando1

    1Wake Forest Baptist Medical Center, Winston-Salem, NC, 2University of Wisconsin Hospital and Clinics, Madison, WI, 3Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

    *Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
  • 2022 American Transplant Congress

    Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs

    G. Haeublein1, G. Lombardi1, F. Caro1, R. Carla1, D. Guerrieri1, C. Incardona2, D. Casadei3, E. Chuluyan1

    1CEFYBO, Buenos Aires, Argentina, 2GADOR S.A., Buenos Aires, Argentina, 3Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina

    *Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
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