ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Antibody-Mediated Allograft Rejection is Associated with an Increase in Peripheral Differentiated Cd28-cd8+ T Cells – Analyses of a Cohort of 1032 Kidney Transplant Recipients

    H. L. Mai1, N. Degauque1, S. Le Bot1, M. Rimbert1, K. Renaudin1, R. Danger1, F. Le Borgne2, C. Kerleau1, F. Delbos3, M. Giral1, S. Brouard1

    1UMR 1064 - CRTI, INSERM - CHU de Nantes, Nantes, France, 2UMR 1046 - SPHERE, INSERM - IDBC-A2COM, Nantes, France, 3Etablissement Français du Sang (EFS) - CHU de Nantes, Nantes, France

    *Purpose: CD28-CD8+ T cells represent a differentiated CD8+ T cell subset that is found to be increased in various conditions associated with chronic antigenic stimulation…
  • 2022 American Transplant Congress

    Use of Everolimus and Reduced Calcineurin Inhibitors in Bk Nephropathy: Insights from Follow-Up and Surveillance Biopsies

    Z. S. Zaky, M. Spinner, B. Stephany

    Cleveland Clinic, Cleveland, OH

    *Purpose: BK virus-associated nephropathy (BKVAN) is a clinically important entity that results in an allograft loss in kidney transplant recipients (KTRs). Mammalian target of rapamycin…
  • 2022 American Transplant Congress

    Characterisation of Kidney-Specific Extracellular Vesicles During Isolated Organ Normothermic Machine Perfusion

    J. Ashcroft1, T. L. Williams2, T. R. Elliott1, A. Marton1, S. A. Hosgood1, M. L. Nicholson1, V. Kosmoliaptsis1

    1Department of Surgery, University of Cambridge, Cambridge, United Kingdom, 2Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

    *Purpose: Introduction: Normothermic machine perfusion (NMP) can evaluate and recondition deceased-donor kidneys but accurate biomarkers are needed to assess organ quality and to predict post-transplant…
  • 2022 American Transplant Congress

    Comparison of IGG and IGM Type B Cell Receptor-Mediated MTOR Phosphorylation Signal

    Y. Matsuda

    Division of Transplant Immunology, Division of Transplant Immunology, Tokyo, Japan

    *Purpose: IgG and IgM memory B cells (mBCs) corresponding donor-specific antigen are closely involved in the activation of humoral immunity against transplanted grafts. Therefore, it…
  • 2022 American Transplant Congress

    Revisiting Late Graft Loss or Death in Pediatric Liver Transplantation Through Analysis of the SPLIT Database

    J. E. Squires1, J. Bilhartz2, K. Soltys1, E. Hafberg3, G. V. Mazariegos1, N. Gupta4, R. Anand5, S. G. Anderson5, T. Miloh6

    1UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 2C. S. Mott Children's Hospital, Ann Arbor, MI, 3Vanderbilt University School of Medicine, Nashville, TN, 4Children's Healthcare of Atlanta and Emory University School of Medicine, Attlanta, GA, 5The Emmes Company, Rockville, MD, 6University of Miami, Miami, FL

    *Purpose: With advances in surgical techniques, medical management, and more equitable allocation systems, children who receive a liver transplant today can expect remarkable outcomes early…
  • 2022 American Transplant Congress

    The Limited Role of Liver Transplantation in Porto-Pulmonary Hypertension Pathology

    J. Doi1, M. Fujiki2, S. Chaudhry1, T. Diago1, F. Aucejo1, C. Kwon1, B. Eghtesad3, C. Miller4, C. Quintini5, K. Hashimoto1

    1Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic Foundation, Cleveland, OH, 3The Cleveland Clinic, Cleveland, OH, 4The Cleveland Clinic, Bratenahl, OH, 5Cleveland Clinic, Beachwood, OH

    *Purpose: Portopulmonary hypertension (POPH) refers to pulmonary artery hypertension (PH) as a consequence of portal hypertension with or without liver disease. Previous studies used pulmonary…
  • 2022 American Transplant Congress

    Defining New Arterial and Arteriolar Lesions Accompanying Transplant Glomerulopathy: Potential Additions to the Histologic Assessment of ABMR

    A. Perkowska-Ptasinska1, D. Deborska-Materkowska2, M. Ciszek3, M. Myslak4, J. Chang5, J. Reeve6, P. Halloran7

    1Pathology, Medical University of Warsaw, Warsaw, Poland, 2Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland, 3Immunology, Transplantation Medicine and Internal Diseases, Medical University of Warsaw, Warsaw, Poland, 4Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, Szczecin, Poland, 5Alberta Transplant Applied Genomics Center, Edmonton, AB, Canada, 6Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 7Pathology, Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada

    *Purpose: Transplant glomerulopathy (TG) results from chronic endothelial injury most commonly related to ABMR. Surprisingly, except for PTC, the relation between TG and other vascular…
  • 2022 American Transplant Congress

    Performance of Donor Derived Cell Free DNA (dd-cfDNA) in Diagnosing Subclinical and Clinical Acute Rejection in Kidney Transplant Recipients

    T. Cober, P. West-Thielke, C. Miller, N. Grund, M. Altrich, A. Sutton, R. Sinha, M. Miller, S. Kleiboeker, J. Weems

    Eurofins, Framingham, MA

    *Purpose: The aim of this study was to examine the performance of Viracor TRAC donor derived cell free DNA (dd-cfDNA) in for-cause biopsies as well…
  • 2022 American Transplant Congress

    Evaluation of Technical Bladder Complications in Kidney Transplantation Recipients with a Prolonged Dialysis History

    S. M. Zielsdorf, K. Kushwaha, C. Goldbeck, S. Martin, Y. Kwon, K. Etesami, J. Kim, J. Emamaullee, S. Zielsdorf

    University of Southern California, Los Angeles, CA

    *Purpose: The kidney transplant (KT) waiting list continues to expand, resulting in prolonged dialysis times of >8 years prior to transplantation in some regions. The…
  • 2022 American Transplant Congress

    De Novo Anti-Brush Border Antibody Disease in a Kidney Transplant Recipient

    P. Yenebere, D. Ibrahim, T. Nadasdy, R. Daloul

    Ohio State University, Columbus, OH

    *Purpose: Anti-brush border antibody (ABBA) disease is very rare, characterized by tubulointerstitial damage caused by autoantibodies against LDL receptor-related protein 2 (LRP2) in the proximal…
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