Am J Transplant, Volume 22, Suppl 3 Archives - Page 19 of 190 - ATC Abstracts

2022 American Transplant Congress
Impact of Early versus Late Initiation of Sirolimus Regimens on Mortality After Kidney Transplantation: Age-Stratified Analyses of Adult Recipients
A. Santos¹, H. Ibrahim¹, M. A. Leghrouz¹, X. Wen²
¹University of Florida, Gainesville, FL, ²University of Rhode Island, Kingston, FL
*Purpose: Observational and meta-analytic studies have associated sirolimus with an increased risk of mortality in kidney transplant (KT) recipients (KTRs). We aimed to examine the…
2022 American Transplant Congress
Disparities in Liver Transplant Access for HCC Patients Based on Patient Blood Type and the Intensity of Competition for Organs Under MMAT-3
A. J. Ahearn, H. Chowdhry, J. L. Dodge, K. Zhou
University of Southern California, Los Angeles, CA
*Purpose: Recent policy changes (acuity circles and MMAT-3 for HCC MELD exception) aimed to reduce geographic disparities in access to liver transplant (LT) and mitigate…
2022 American Transplant Congress
Lung Transplantation After Ex Vivo Lung Perfusion, Early and Mid-Term Outcomes
K. Noda, E. G. Chan, J. Ryan, M. Furukawa, J. D. Luketich, P. G. Sanchez
Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: The safety of lung transplantation using ex vivo lung perfusion (EVLP) has been confirmed by multiple clinical studies, however, limited evidence is currently available…
2022 American Transplant Congress
The Effects of Race-Matching in Small Intestine Transplantation
C. G. Yergin¹, C. Warren², S. Duarte³, T. Beduschi⁴, A. Zarrinpar⁵
¹College of Medicine, University of Florida, Gainesville, FL, ²-, -, AL, ³University of Florida, Gainesville, FL, ⁴Department of Surgery, University of Florida, Gainesville, FL, ⁵University of California Los Angeles, Gainesville, FL
*Purpose: We sought to investigate whether race-matching in small intestine (SI) transplantation correlates with better transplantation outcomes, as well as lower odds of graft rejection.*Methods:…
2022 American Transplant Congress
Artificial Mitochondria Transfer to Mitigate Ischemic Damage in an In Vitro Model of Tubular Injury and in an Ex Vivo Porcine Model of DCD Renal Transplantation
A. Rossi¹, S. Sedrakyan², F. Montali³, C. Aardena⁴, N. Abraham⁵, A. Barbas⁵, L. N. Byers⁶, C. Palles⁷, A. Asthana⁶, J. Robertson⁴, L. Perin², R. Senger⁴, B. Bussolati¹, G. Orlando⁸
¹Un. of Turin, Turin, Italy, ²Children Hospital, Los Angeles, CA, ³Un. of L'Aquila, L'Aquila, Italy, ⁴VA Tech, Blacksburg, VA, ⁵Duke, Durham, NC, ⁶WFIRM, Winston Salem, NC, ⁷University of Florida, Gainesville, FL, ⁸Wake Forest Baptist, Winston-Salem, NC
*Purpose: We aimed at assessing whether artificial mitochondrial transfer (AMT) mitigates renal injury in an in vitro model of tubular damage and in an ex…
2022 American Transplant Congress
Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance
T. Hirai¹, P. Lin², T. L Ramos², K. Garcia³, R. S Negrin²
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA
*Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
2022 American Transplant Congress
Tolerant B Cells Suppress Memory B Cells in a Donor Specific Manner in CoB Mediated Transplantation Tolerance
S. Durgam¹, D. Yin¹, M. Alegre², A. Chong¹
¹Surgery, section of transplant immunology, University of Chicago, Chicago, IL, ²Medicine, section of rheumatology, University of Chicago, Chicago, IL
*Purpose: We previously reported that B cells in recipients made tolerant to fully mismatched heart allografts by anti-CD154+donor spleen cells (CoB) become dysfunctional in their…
2022 American Transplant Congress
De Novo Fibrinogen Alpha Chain Amyloidosis in Kidney Allograft
T. Khaja¹, L. Truong², G. Nassar¹
¹Nephrology, Houston Methodist Hospital, Houston, TX, ²Pathology, Houston Methodist Hospital, Houston, TX
*Purpose: Amyloidosis is a disorder characterized by tissue deposition of misfolded proteins that can lead to organ damage such as renal failure. There are multiple…
2022 American Transplant Congress
Galectin-3 Expression in Autoimmune Hepatitis
N. Limon-de la Rosa¹, C. Moreno-Ramírez², E. Cervantes-Alvarez³, D. Yoeli⁴, I. Vasic⁴, M. Kriss⁵, C. A. Huang⁴, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Universidad de Guadalajara , Centro Universitario de la Costa., Puerto Vallarta Jalisco, Mexico, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴University of Colorado Anschutz Medical Campus, Denver, CO, ⁵University of Colorado Anschutz Medical Campus, Aurora, CO
*Purpose: Autoimmune hepatitis (AIH) is characterized by chronic inflammation in which healthy liver cells are targeted by one’s immune system. The persistent inflammatory milieu can…
2022 American Transplant Congress
Long-Term Low-Dose Corticosteroid Therapy Can Suppress Calcineurin Inhibitor Induced Nephrotoxicity without Steroid-Related Complication in Living Kidney Transplant Recipient
H. Sasaki, H. Harada, D. Takamoto, Y. Takada, S. Harada, H. Tanaka
Sapporo City General Hospital, Sapporo, Japan
*Purpose: The induction of calcineurin inhibitors (CNI) greatly reduced the rate of allograft rejection, although their chronic use resulted in vascular inflammation in kidney transplant…