ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Is Pathologic AMR Grading Scale Associated with the Presence of Donor-Specific Antibodies?

    S. Kim, J. Patel, M. Kittleson, T. Singer-Englar, N. Patel, D. Chang, E. Kransdorf, D. Emerson, J. A. Kobashigawa

    Cedars-Sinai Smidt Heart Institute, Los Angeles, CA

    *Purpose: Antibody-mediated rejection (AMR) has been defined by an expert pathology group in 2011 which resulted in the ISHLT pathologic AMR (pAMR) grading scale. The…
  • 2022 American Transplant Congress

    Bacterial Infections After Kidney Transplant Before and After the COVID-19 Pandemic

    A. Perez Gutierrez1, B. Juengel1, S. Krishnamoorthy2, P. J. Bachul1, P. Witkowski3, R. Barth3, J. Fung1

    1Department of Surgery, University of Chicago Medicine, Chicago, IL, 2Department of Medicine, University of Chicago Medicine, Chicago, IL, 3University of Chicago Medicine, Chicago, IL

    *Purpose: Infectious complications are a major cause of mortality and morbidity after kidney transplantation. During the COVID-19 pandemia there were several changes in the management…
  • 2022 American Transplant Congress

    Comparison of Cephalexin and Ciprofloxacin Prophylaxis for Urinary Tract Infection in Kidney Transplant Recipients

    N. A. Pauley, M. Fitzmaurice, A. Poparad-Stezar, B. Summers, A. Jantz

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    *Purpose: Compare efficacy and safety outcomes of patients (pts) that received alternative agents as prophylaxis (ppx) for urinary tract infection (UTI) after kidney transplant (KT)…
  • 2022 American Transplant Congress

    Outcome of Heart Transplantation After Pseudomonas Left Ventricular Assist Device Infection

    L. Thirunavukarasu Murugan1, C. Koval2, J. Banzon3

    1Infectious Disease, Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic Foundation, Cleveland, OH, 3Cleveland Clinic, Cleveland, OH

    *Purpose: Pseudomonas aeruginosa (PA) is the most common gram-negative bacteria to cause left ventricular assist device (LVAD) infection. Management is difficult given limited oral antibiotic…
  • 2022 American Transplant Congress

    Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes

    C. M. Darden1, S. Vasu2, J. Mattke3, Y. Liu2, B. Naziruddin4, M. C. Lawrence2

    1Baylor University, Dallas, TX, 2Baylor University Medical Center, Dallas, TX, 3Baylor University, Waco, TX, 4Baylor University Medical Ctr, Dallas, TX

    *Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
  • 2022 American Transplant Congress

    The Role of LAG3 in Antibody Responses to Kidney Transplantation

    M. Nicosia1, R. Fan1, J. Lee2, V. Gorbacheva1, A. M. Beavers1, N. Dvorina1, W. Baldwin III1, R. L. Fairchild1, B. Min3, A. Valujskikh1

    1Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 2Cardiovascular and Metabolic Science, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 3Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL

    *Purpose: The functions of coinhibitory receptor lymphocyte activation gene-3 (LAG3) in T cells are well studied, however its role in humoral immune responses remains poorly…
  • 2022 American Transplant Congress

    TCMR in Late Kidney Transplant Biopsies Shows Less Molecular TCMR Activity and More Fibrosis Despite Persistence of Tubulitis and Interstitial Infiltrate

    K. S. Madill-Thomsen1, J. Reeve1, P. Halloran1, .. and the INTERCOMEX Study Group2

    1Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, 2., ., AB, Canada

    *Purpose: We studied the relationship between time post-transplant and molecular T cell-mediated rejection (TCMR) activity in a population of indication kidney transplant biopsies.*Methods: Updated rejection-based…
  • 2022 American Transplant Congress

    Factor V Leiden Heterozygosity and Live Donor Liver Donation – A Single Center Analysis

    D. Reddy, S. Ganesh, A. M. Thompson, V. Gunabushanam, A. Ganoza, M. Molinari, A. Tevar, C. Hughes, A. Humar

    Thomas E Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA

    *Purpose: Living donor liver transplantation (LDLT) accounts for only a small percentage (< 6%) of all liver transplants performed for adult recipients in the western…
  • 2022 American Transplant Congress

    Organ Transplant Outcomes from Donors with Positive SARS-CoV-2 PCRs in New York: A Case Series

    A. L. Friedman1, M. Pereira2, M. Rana3, J. Akpede4, A. Dhand5

    1LiveOnNY, New York, NY, 2New York Presbyterian Hospital, New York, NY, 3Icahn School of Medicine at Mount Sinai, New York, NY, 4LiveOnNY, Long Island City, NY, 5Westchester Medical Center, Chappaqua, NY

    *Purpose: Rapid evolution of the SARS-CoV-2 pandemic over the past 24 months has demanded agility in managing selection criteria for deceased organ donors, with the…
  • 2022 American Transplant Congress

    Survey of Current Transplant Center Practices Regarding Covid-19 Vaccine Mandates in the United States

    B. E. Hippen1, D. Axelrod2, K. Maher3, R. Xi3, D. Kumar4, M. Schnitzler3, K. Lentine3

    1Head of Transplant Medicine, Fresenius Medical Care, Charlotte, NC, 2University of Iowa Transplant Clinic, Iowa City, IA, 3St. Louis University School of Medicine, St. Louis, MO, 4Ajmera Transplant Centre, Toronto, ON, Canada

    *Purpose: We surveyed current policies of transplant centers regarding a COVID-19 vaccine mandate, and rationales for or against a mandate policy.*Methods: An electronic survey was…
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