Am J Transplant, Volume 22, Suppl 3 Archives - Page 186 of 190 - ATC Abstracts

2022 American Transplant Congress
Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination
N. M. Ali¹, J. Miles², S. Mehta¹, V. Tatapudi¹, Z. Stewart¹, B. Lonze¹, M. Mangiola¹, C. DiMaggio¹, E. Weldon¹, I. Saeed¹, J. Leonard¹, R. Herati¹, J. Thomas¹, J. Michael¹, C. Hickson¹, K. Cartiera¹, R. Montgomery¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY
*Purpose: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection after SARS-CoV-2 vaccination have…
2022 American Transplant Congress
Inflammation After Kidney Transplantation Is Associated With Overall- And Death-censored Graft Loss
T. F. Heldal, T. Jenssen, A. Hartmann, K. Heldal, A. Asberg
Department of Transplantational Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: Early graft loss after kidney transplantation (KT) is mainly a result of acute rejection, while long-term graft loss episodes are often dependent on multifactorial…
2022 American Transplant Congress
A Randomized Phase 2 Study Of Mau868 Vs Placebo To Treat Bk Viremia In Kidney Transplant Recipients
S. Jordan¹, A. P. Limaye², B. Fischbach³, P. Sood⁴, S. Collette⁵, L. Gasink⁶, M. W. Fordyce⁷, C. J. Lin⁷, M. Hodges⁶, D. C. Brennan⁸
¹Cedars-Sinai Medical Center, Los Angeles, CA, ²University of Washington, Seattle, WA, ³Dallas Nephrology Associates, Inc, Dallas, TX, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada, ⁶previous employee/consultant for Amplyx Pharmaceuticals, San Diego, CA, ⁷Vera Therapeutics, Inc, Brisbane, CA, ⁸Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: To assess the safety and efficacy of MAU868, a BK virus-specific monoclonal antibody, in adult kidney transplant recipients with BK viremia.*Methods: This is a…
2022 American Transplant Congress
Superoxide in Cardiac Allografts from Donors After Circulatory Death
M. Urban¹, T. Bruett², K. F. Duncan¹, N. W. Markin³, M. M. Chacon³, M. C. Zimmerman⁴
¹Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, ²College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, ³Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE
*Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
A. Asthana¹, D. Chaimov¹, R. Tamburrini², S. J. Walker³, G. Orlando¹
¹Wake Forest Baptist Medical Center, Winston-Salem, NC, ²University of Wisconsin Hospital and Clinics, Madison, WI, ³Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
2022 American Transplant Congress
Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs
G. Haeublein¹, G. Lombardi¹, F. Caro¹, R. Carla¹, D. Guerrieri¹, C. Incardona², D. Casadei³, E. Chuluyan¹
¹CEFYBO, Buenos Aires, Argentina, ²GADOR S.A., Buenos Aires, Argentina, ³Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina
*Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
2022 American Transplant Congress
Enhancing Early Nerve Regeneration from Reconstruction of a Segmental Nerve Injury with Polyethylene Glycol
A. Bernal¹, C. Hinshaw¹, J. Hinshaw¹, C. Yang², S. Margaux¹, W. Zhang¹, J. Nuelle¹, C. Sabbag¹, G. Bittner², J. Shores³, E. Weitzel¹, J. Alderete¹
¹RESTOR FUSE Nerve Reconstruction Consortium, US Army Institute of Surgical Research/59th MDW, San Antonio, TX, ²University of Texas at Austin, Austin, TX, ³John Hopkins University, Baltimore, MD
*Purpose: Despite advancements in understanding and treating peripheral nerve injuries (PNIs), restoration of lost motor and sensory functions remain poor using current methods of clinical…
2022 American Transplant Congress
Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK
H. Zhang¹, M. Ni², J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, W. Li³, X. Wang², Y. E. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³China-Japan Union Hospital of Jilin University, JiLing, China
*Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…
2022 American Transplant Congress
Characterization of Acute Kidney Injury in Fatty Liver Ischemia Reperfusion Injury
Z. P. Rokop, W. Zhang, N. Ghosh, A. Das, N. Biswas, C. Sen, C. Kubal
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The association between hepatic ischemia reperfusion injury (hIRI) and acute kidney injury (AKI) has been well established. AKI is commonly observed following transplantation of…
2022 American Transplant Congress
Immunogenicity of a 3rd Dose of Mrna Covid-19 Vaccine in Kidney Transplant Recipients Who Failed to Respond to 2 Prior Doses
W. Werbel¹, A. Karaba¹, T. Chiang¹, T. Liang¹, A. Massie¹, M. Bettinotti¹, W. Clarke¹, N. Watson², A. Tobian¹, C. Durand¹, N. Bridges², D. Rostrosen², C. Larsen³, P. Heeger⁴, D. Segev¹
¹Johns Hopkins, Baltimore, MD, ²NIAID, Bethesda, MD, ³Emory University, Atlanta, GA, ⁴Mt. Sinai School of Medicine, New York, NY
*Purpose: Kidney transplant recipients (KTRs) have diminished immune response and protection after 2-dose mRNA COVID-19 vaccination. It is unknown if additional doses improve neutralization of…