2022 American Transplant Congress
Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation
*Purpose: Human hepatocellular damage caused by ischemia reperfusion injury (IRI) generates the disulfide form of HMGB1 (diS HMGB1), eliciting myeloid cell activation and proinflammatory cytokine…2022 American Transplant Congress
Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc
*Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…2022 American Transplant Congress
Dynamic Risk Prediction of Kidney Graft Failure After Deceased Donor Transplant
*Purpose: Identifying kidney transplant recipients at risk of graft failure allows for early intervention in clinical care. We developed a dynamic risk prediction model based…2022 American Transplant Congress
18 Month Review of Liver Acuity Circles Allocation
*Purpose: Acuity circles (AC) allocation was implemented on 2/4/2020 with a goal of removing DSA and region from liver allocation and broadening the distribution of…2022 American Transplant Congress
Increased Waitlist Mortality in Pediatric Liver Transplant Candidates with Greater Distance from Transplant Center
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Greater distance from transplant center in adult liver transplant (LT) candidates is associated with increased waitlist mortality. Pediatric LT candidates have higher waitlist mortality…2022 American Transplant Congress
25 Years of a Standardized Living Donor (LD) Intestinal Transplant Technique – What Has Been Achieved?
1SUNY Downstate Medical Center, Brooklyn, NY, 2SUNY Downstate Medical Center, Brooklyn, MA
*Purpose: The indication for intestinal transplantation (ITX) is irreversible intestinal failure with dependence on total parenteral nutrition (TPN). Most intestinal transplants are from deceased donors…2022 American Transplant Congress
Perfusate Metabolites and Association with Pump Perfusion and Allograft Failure
*Purpose: While hypothermic machine perfusion (HMP) is associated with improved kidney graft viability, the exact biological mechanisms underlying this association are unknown. The goal of…2022 American Transplant Congress
T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism
*Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…2022 American Transplant Congress
Dynamic Changes in Titer and Specificity Autoantibodies in Chronic Bm12 to B/6 Kidney Rejection
*Purpose: Loss of autoreactive B cell tolerance and production of non-HLA autoantibodies have been observed in patients undergoing chronic rejection, however, how autoreactive B cells…2022 American Transplant Congress
Molecular Characterization of the Plasma Secretome in Pediatric Liver Transplantation (pLTx) Identified Cytokine/Chemokine Signatures Potentially Linked to Beneficial Immunosuppressive Regimes (IS) and Recovery
*Purpose: In the European multicentre “ChilSFree” study we aimed to characterize longitudinal dynamics of soluble immune mediators during the first year after pLTx.*Methods: Using Luminex-based…
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