Am J Transplant, Volume 22, Suppl 3 Archives - Page 179 of 190 - ATC Abstracts

2022 American Transplant Congress
Ultrasound Targeted Microbubble Cavitation During Ex Vivo Normothermic Machine Perfusion Reduces Peribiliary Vascular Plexus Thrombi and Graft Injury in a DCD Liver Transplant Model
Y. Nigmet¹, C. Hughes¹, X. Chen², A. Demetris³, D. Stolz⁴, J. Pacella², A. Humar⁵, F. Villanueva²
¹Transplant Surgery, University of Pittsburgh, Pittsburgh, PA, ²Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, PA, ³Transplant Pathology, University of Pittsburgh, Pittsburgh, PA, ⁴Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, ⁵Thomas E Starzl Transplant Inst, Pittsburgh, PA
*Purpose: Thrombus formation in the peribiliary vascular plexus (PBP) is a proposed mechanism for ischemic cholangiopathy (IC) after liver transplantation from donors after circulatory death…
2022 American Transplant Congress
Higher Hepatocellular Carcinoma Tumor Burden Score is Associated with Grater Liver Transplant Survival Benefit
H. Liu¹, W. Zhang², M. Di³, H. Lee⁴, R. Cruz¹, X. Wang², C. Kaltenmeier¹, A. Thompson¹, D. Reddy¹, E. Ashwat¹, M. D'Alesio¹, S. Lebowitz¹, S. Tohme¹, D. Geller¹, A. Tevar¹, C. Hughes¹, A. Humar¹, J. Behari⁵, R. Bataller⁵, S. Hariharan⁵, M. Molinari¹
¹Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Mathematics and Statistics, University of Arkansas at Little Rock, Little Rock, AR, ³Medicine, Medical Oncology, Yale University, New Haven, CT, ⁴Biostatistics, Massachusetts General Hospital, Boston, MA, ⁵Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Liver transplantation(LT) is the best treatment option for early-stage hepatocellular carcinoma(HCC) and cirrhosis. However, patients with various tumor burdens receive identical listing priority, despite…
2022 American Transplant Congress
Cell-Free DNA Concentration in Hypothermic Machine Perfusate is a Potential Rapid Marker for Kidney Graft Quality
S. Duarte¹, M. Willman¹, V. Boominathan¹, D. Lewis¹, W. De Faria¹, G. Vrakas¹, A. El-Hinnawi¹, T. Beduschi¹, N. Battula², A. Zarrinpar¹
¹University of Florida, Gainesville, FL, ²University of Oklahoma Medical College, Oklahoma City, OK
*Purpose: The successful use of hypothermic machine perfusion (HMP) as a clinical modality for graft preservation prior to kidney transplantation (KTx) has generated a demand…
2022 American Transplant Congress
Metabolic Outcomes After Simultaneous Pancreas Kidney Transplant from Donation After Circulatory Death Donors – The UK Registry Analysis
J. Gopal, A. McLean, A. Muthusamy
Imperial College Renal and Transplant Center, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom
*Purpose: DCD pancreas transplantation is established as a valuable cohort to expand the pancreas donor pool, with equivalent graft & patient survival compared to pancreases…
2022 American Transplant Congress
Is Pathologic AMR Grading Scale Associated with the Presence of Donor-Specific Antibodies?
S. Kim, J. Patel, M. Kittleson, T. Singer-Englar, N. Patel, D. Chang, E. Kransdorf, D. Emerson, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) has been defined by an expert pathology group in 2011 which resulted in the ISHLT pathologic AMR (pAMR) grading scale. The…
2022 American Transplant Congress
Bacterial Infections After Kidney Transplant Before and After the COVID-19 Pandemic
A. Perez Gutierrez¹, B. Juengel¹, S. Krishnamoorthy², P. J. Bachul¹, P. Witkowski³, R. Barth³, J. Fung¹
¹Department of Surgery, University of Chicago Medicine, Chicago, IL, ²Department of Medicine, University of Chicago Medicine, Chicago, IL, ³University of Chicago Medicine, Chicago, IL
*Purpose: Infectious complications are a major cause of mortality and morbidity after kidney transplantation. During the COVID-19 pandemia there were several changes in the management…
2022 American Transplant Congress
Comparison of Cephalexin and Ciprofloxacin Prophylaxis for Urinary Tract Infection in Kidney Transplant Recipients
N. A. Pauley, M. Fitzmaurice, A. Poparad-Stezar, B. Summers, A. Jantz
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Compare efficacy and safety outcomes of patients (pts) that received alternative agents as prophylaxis (ppx) for urinary tract infection (UTI) after kidney transplant (KT)…
2022 American Transplant Congress
Outcome of Heart Transplantation After Pseudomonas Left Ventricular Assist Device Infection
L. Thirunavukarasu Murugan¹, C. Koval², J. Banzon³
¹Infectious Disease, Cleveland Clinic, Cleveland, OH, ²Cleveland Clinic Foundation, Cleveland, OH, ³Cleveland Clinic, Cleveland, OH
*Purpose: Pseudomonas aeruginosa (PA) is the most common gram-negative bacteria to cause left ventricular assist device (LVAD) infection. Management is difficult given limited oral antibiotic…
2022 American Transplant Congress
Tacrolimus Induces Dedifferentiation of Pancreatic Beta Cells by Inhibition of Calcineurin/NFATc2 and Islet Cell Differentiation Genes
C. M. Darden¹, S. Vasu², J. Mattke³, Y. Liu², B. Naziruddin⁴, M. C. Lawrence²
¹Baylor University, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX, ⁴Baylor University Medical Ctr, Dallas, TX
*Purpose: Tacrolimus (FK506) is a potent immunosuppressant widely used for solid organ transplantation to prevent lymphokine gene expression by inhibiting calcineurin (CN) and its downstream…
2022 American Transplant Congress
The Role of LAG3 in Antibody Responses to Kidney Transplantation
M. Nicosia¹, R. Fan¹, J. Lee², V. Gorbacheva¹, A. M. Beavers¹, N. Dvorina¹, W. Baldwin III¹, R. L. Fairchild¹, B. Min³, A. Valujskikh¹
¹Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ²Cardiovascular and Metabolic Science, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, ³Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: The functions of coinhibitory receptor lymphocyte activation gene-3 (LAG3) in T cells are well studied, however its role in humoral immune responses remains poorly…