2022 American Transplant Congress
Single Dose Alemtuzemab Provides Comparable Rejection Free and Infection Free Survival Compared to Double Dose Alemtuzumab. In Comparison to Alemtuzemab, Basiliximab Has Superior Infection Free Graft Survival. Results from a Steroid Sparing Transplant Group
Department of Transplant Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom
*Purpose: The present study investigated the short-term biopsy-proven acute rejection rates and viral infection rates amongst our protocol of single-dose Alemtuzemab (Cohort 1) versus double…2022 American Transplant Congress
Daratumumab Therapy Achieves Dialysis Independence in Kidney Transplant Recipients with Resistant Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits
The Ohio State University, Columbus, OH
*Purpose: Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a unique cause for monoclonal gammopathy of renal significance with overall poor prognosis. Patients are frequently…2022 American Transplant Congress
Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines
*Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…2022 American Transplant Congress
Benefits and Risks of Induction Immunosuppression Therapy in Pediatric Liver Transplantation
University of Pennsylvania, Philadelphia, PA
*Purpose: To investigate trends in induction therapy use in pediatric liver transplantation (LT) in the U.S. and evaluate the potential benefits and risks of induction…2022 American Transplant Congress
Characteristics of OPOs with Increased Education Spending, 2013-2018
*Purpose: OPO spending on education would be expected to increase donor registration and increase the number of donors. Using data from multiple sources, we examined…2022 American Transplant Congress
Simultaneous Lung and Kidney Transplant in a Young Patient with COVID-19
*Purpose: Lung transplant is the last resort for COVID-19 refractory ARDS. Dual organ transplant is seen as a relative contraindication at many institutions. We describe…2022 American Transplant Congress
Years Of Life Gained Through Organ Transplantation From Donors Deceased From Drug Overdose
Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD
*Purpose: The worsening opioid crisis in the United States has increased the availability of organs from donors who died of drug overdoses. The goal of…2022 American Transplant Congress
Treg Crosstalk with Both Tumor and Lymphatic Cells Promotes Metastasis Through Lta1b2-ltbr Signaling
1Surgery, University of Maryland, Baltimore, MD, 2University of Maryland, College Park, MD
*Purpose: Lymphotoxin (LT) α1β2 high expressing Tregs are essential for immune tolerance although inhibiting antitumor immunity. Lymphatic endothelial cells (LEC) express the LT beta-receptor (LTβR),…2022 American Transplant Congress
First-in-human Study Of Lis1, A Novel Glyco-humanized Anti-lymphocyte Swine Polyclonal Antibody, In Kidney Transplantation: Safety And Efficacy
*Purpose: to assess safety, T cell depletion, PK/PD and determine the therapeutic dose of LIS1, a purified anti-lymphocyte glyco-humanized polyclonal swine IgG, derived by immunizing…2022 American Transplant Congress
Clazakizumab® (anti-il-6) Desensitization in Highly-HLA Sensitized Patients Awaiting Kidney Transplant (nct03380962): Long-Term Follow Up
*Purpose: IL-6 is a cytokine critical for B-cell activation and IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6.…
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