Am J Transplant, Volume 22, Suppl 3 Archives - Page 173 of 190 - ATC Abstracts

2022 American Transplant Congress
Beyond CPRA: Identifying Sensitized Kidney Candidates with Markedly Low Access to Transplant
K. Bradbrook¹, A. Maldonado², K. Sjöholm², C. Kjellman², J. Lee³, D. Stewart¹
¹UNOS, Richmond, VA, ²Hansa Biopharma AB, Lund, Sweden, ³Immucor, Norcross, GA
*Purpose: The Kidney Allocation System (KAS) improved the rates of transplantation in highly sensitized (HS) patients. However, a subset of HS patients remain at a…
2022 American Transplant Congress
Natural vs Induced ABO Antibodies in a Murine Model: Role of Sex and T Cells
I. Adam¹, B. Motyka¹, K. Tao¹, P. J. Cowan², L. J. West¹
¹University of Alberta, Edmonton, AB, Canada, ²University of Melbourne, Melbourne, Australia
*Purpose: Interaction of ‘natural’ ABO antibodies (nAbs) with their cognate AB(H)-antigens (Ags) poses a high risk of rapid rejection of ABO-incompatible (ABOi) organ transplants. We…
2022 American Transplant Congress
Generation Of Insulin Producing Cells From Pancreatic Tissue With Long Standing Type 1 Diabetes
Y. Garciafigueroa, J. B. Pollett, N. L. Thai, R. Bottino
Imagine Pharma, Pittsburgh, PA
*Purpose: AIPCs (Activated Islet Proliferating Cells), are a novel cell population from isolated human islets obtained using a simple culture protocol that can generate cells…
2022 American Transplant Congress
Belatacept Conversion in Proteinuric Kidney Transplant Recipients: Effects in a Prospective Trial and a Retrospective Cohort
O. Efe¹, A. Al Jurdi¹, D. Wojciechowski², K. Safa¹, H. Gilligan¹, A. Chandraker³, J. Azzi³, A. Weins³, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²UT Southwestern Medical Center, Dallas, TX, ³Brigham and Women's Hospital, Boston, MA
*Purpose: Proteinuria after kidney transplantation is associated with worse allograft outcomes. B7-1 expression by podocytes has been linked to proteinuria by inducing podocyte migration which…
2022 American Transplant Congress
Sex Disparities in Access to Liver Transplant for Waitlisted Patients with Meld 40
D. C. Cron¹, H. Yeh¹, H. J. Braun², N. L. Ascher², D. C. Chang¹, J. T. Adler³
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Surgery, University of California San Francisco, San Francisco, CA, ³Surgery and Perioperative Care, University of Texas at Austin, Austin, TX
*Purpose: Women with end-stage liver disease are less likely than men to receive a liver transplant, due in part to MELD’s reliance on creatinine and…
2022 American Transplant Congress
Role for Club Cell Secretory Protein in Inducing Exosomes and Activation of Immune Responses in Lung Transplanted Recipients for Cystic Fibrosis
R. Ravichandran¹, V. Kaza², R. Bremner¹, M. Smith¹, T. Mohanakumar¹
¹St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²University of Texas Southwestern, Dallas, TX
*Purpose: Our lab has demonstrated that lower club cell secretory protein leads to immune responses to donor HLA and lung self-antigens (Collagen V, Kα1 Tubulin),…
2022 American Transplant Congress
Pre-Transplant Frailty Predicts Infection After Liver Transplant in a Multi-Center Study of Older Adults
M. Malinis¹, M. Abidi², E. Benamu², N. Jakharia³, N. Law⁴, R. Sigler⁴, R. Nog⁵, S. Olivier⁵, S. Taimur⁶, N. Theodoropoulos⁷, J. Schaenman⁸
¹Yale SOM, New Haven, CT, ²Univ of CO, Aurora, CO, ³Stanford, Palo, Alto, CA, ⁴UCSD, San Diego, CA, ⁵Westchester Med Ctr, Westchester, NY, ⁶Mount Sinai SOM, New York, NY, ⁷Univ of MA, Worcester, MA, ⁸UCLA, Los Angeles, CA
*Purpose: Frailty is a complex multi-system characterization of reduced physiologic reserve and functional decline in older adults. At the time of transplant, frailty has been…
2022 American Transplant Congress
Hepatocyte SIRT1 Regulation of Apoptosis-Mediated Pyroptosis Cell Death in Mouse and Human Liver Transplantation
K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, X. Li², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²NIEHS, Durham, NC
*Purpose: Cold static preservation is a gold-standard in orthotopic liver transplantation (OLT). However, the role of hepatocyte-specific SIRT1 transcriptional regulation of cell death programs during…
2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹
¹Brigham and Women's Hospital, Boston, MA, ²Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…
2022 American Transplant Congress
Il-33 Induced Regulatory Macrophages Inhibit Transplantation Immune Rejection by Inducing Tregs
J. Wu, F. Zhang, W. Wang
Beijing Chaoyang Hospital, Beijing, China
*Purpose: The occurrence of acute and chronic rejections after transplantation are key factors that affect the survival of the recipients. Induction of transplantation immune tolerance…