Am J Transplant, Volume 22, Suppl 3 Archives - Page 170 of 190 - ATC Abstracts

2022 American Transplant Congress
Abnormal B Cell Profile Associated with Inadequate Antibody Response to MRNA SARS-COV-2 Vaccine Can Be Overcome with a Third Vaccine Dose in Adolescent Kidney Transplant Recipients
C. Crane, E. Phebus, L. Loop, C. Anterasian, B. Geng, E. Ingulli
Pediatrics, UCSD Rady Children's, San Diego, CA
*Purpose: mRNA SARS-CoV-2 vaccines are highly efficacious in the general population but have shown a diminished response in immunosuppressed adolescent kidney allograft recipients. We investigated…
2022 American Transplant Congress
Patient-Reported Physical Function Correlates with Liver Frailty Index and 4-Meter Gait Speed in Patients with Cirrhosis
A. J. Thuluvath, J. Peipert, K. Belfanti, S. Morrissey, O. Siddiqui, J. Levitsky, Z. Dietch, A. Flores, D. P. Ladner
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Frailty is highly prevalent in patients with end-stage liver disease and strongly predicts waitlist and post-transplant mortality. The Liver Frailty Index (LFI) and 4-meter…
2022 American Transplant Congress
The Gut Microbiome in the Critical Care Setting Post-Heart Transplantation
M. Dela Cruz¹, H. Lin², E. Adler², M. Khalid², J. Boissiere², G. Kim¹, S. Pinney¹, E. Pamer², A. Nguyen¹
¹Section of Cardiology, University of Chicago, Chicago, IL, ²Duchossois Family Institute, University of Chicago, Chicago, IL
*Purpose: Given its potential impact on immune activation and systemic inflammation, we aim to investigate gut microbiome compositions and metabolites during critical illness in the…
2022 American Transplant Congress
Utilization and Discard of Organs from Covid -19 Infected Donors: A Us National Registry Analysis
A. Azhar¹, I. Moinuddin¹, A. B. Gungor², M. K. Morales¹, M. Z. Molnar³, B. Tanriover², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²University of Arizona, Tuscon, AZ, ³University of Utah, Salt Lake City, UT
*Purpose: Expansion of the donor pool remains a major unmet need for solid organ transplants (SOT). Early data suggests that at least some severe acute…
2022 American Transplant Congress
FasL-Presenting PEG Microgels Supports Sustained Graft Survival in Nonhuman Primates in the Absence of Continuous Immunosuppression
E. S. Yolcu¹, J. Lei², M. M. Coronel³, H. Deng⁴, Z. Yang⁴, A. Zhang⁴, T. Chen⁵, K. Lee⁴, C. Peters⁴, I. Rosales⁴, Z. Wang⁴, J. Markmann⁴, A. Garcia³, H. Shirwan¹
¹University of Missouri at Columbia, Columbia, MO, ²Surgery, Mass General, Boston, MA, ³Georgia Institute of Technology, Atlanta, GA, ⁴Massachusetts General Hospital, Boston, MA, ⁵Xiamen University Medical School, Xiamen, China
*Purpose: Broad application of allogeneic islets for T1D treatment is curtailed by the use of chronic immunosuppression to control rejection. Teff cells are the major…
2022 American Transplant Congress
Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids
A. Kumar Gupta¹, E. Minocha¹, J. A. Wertheim¹, L. Gallon²
¹Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, ²Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
2022 American Transplant Congress
Cd137 on Host Dendritic Cells Fine-Tunes the Intesity of Donor T Cells in Systemic Alloinmmune Responses
S. Park¹, H. Cho², B. Kwon³, J. Lee⁴, H. Park¹, J. Park⁴, K. Park⁴, K. Yoo⁴
¹Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ²University of Ulsan College of Medicine, Ulsan, Korea, Republic of, ³School of Biological Sciences, University of Ulsan, Ulsan, Korea, Republic of, ⁴Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea, Republic of
*Purpose: CD137 is a potent costimulatory receptor for CD8+ T cells but it also regulates dendritic cells (DCs) to suppress immune responses. In this study,…
2022 American Transplant Congress
Selective CD28 Blockade Impacts T Cell Differentiation During Hematopoietic Reconstitution Following Lymphodepletion
J. Habib, D. Liu, R. L. Crepeau, M. E. Wagener, M. L. Ford
Emory University, Atlanta, GA
*Purpose: Costimulation blockade targeting the CD28 pathway provides improved long-term transplant survival without the nephrotoxicity of calcineurin inhibitors. However, treatment with the CTLA-4Ig fusion protein…
2022 American Transplant Congress
Survival Comparison of Simultaneous Pancreas-Kidney Transplant with Pancreas After Living-Donor Kidney Transplant by Wait Time and Organ Quality
G. R. Lyden¹, E. S. Helgeson², E. B. Finger³, A. J. Matas³, J. J. Snyder⁴, D. M. Vock²
¹Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute; Division of Biostatistics, University of Minnesota, Mpls, MN, ²Div Biostatistics U MN, Mpls, MN, ³Dept Surg U MN, Mpls, MN, ⁴Hennepin Healthcare Research Institute, Mpls, MN
*Purpose: The survival benefit of simultaneous pancreas-kidney (SPK) compared to pancreas after living-donor kidney (PALK) transplant is controversial. Wait times for SPK and donor risk…
2022 American Transplant Congress
Secular Trends in Development of ESRD Following Liver Transplant
J. M. Ruck¹, L. Zeiser¹, A. Massie², D. Segev³, E. King¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins School of Medicine, Baltimore, MD, ³Johns Hopkins University, Baltimore, MD
*Purpose: End-stage renal disease (ESRD) post-liver transplant (LT) is associated with increased mortality, but ESRD incidence and risk factors in LT recipients (LTRs) remain poorly…