Am J Transplant, Volume 22, Suppl 3 Archives - Page 169 of 190 - ATC Abstracts

2022 American Transplant Congress
Bariatric Surgery and Alcohol Related Steatohepatitis (BASH): An Increasing Etiology in Pre-Liver Transplant Candidates
S. Nishida¹, K. Okumura¹, A. Dhand², R. Bodin², S. Yaghoubian³, C. Greenberg¹, R. Misawa¹, G. Veillette¹, H. Sogawa¹, D. John¹, D. C. Wolf², B. Partiula², T. Diflo¹, R. Latifi¹, S. Lansman¹
¹Surgery, Westchester Medical Center/ New York Medical College, Valhalla, NY, ²Medicine, Westchester Medical Center/ New York Medical College, Valhalla, NY, ³Anesthesia, Westchester Medical Center/ New York Medical College, Valhalla, NY
*Purpose: Obesity-related fatty liver disease and non-alcoholic steatohepatitis (NASH) are common causes of End-stage liver disease (ESLD). Bariatric surgery (BS) is commonly indicated for these…
2022 American Transplant Congress
Identification of Soluble and Cellular Biomarkers in Blood of End-Stage Patients Before Pediatric Liver Transplantation (pLTx)
E. Chichelnitskiy¹, L. Ruhl², I. Goldschmidt³, A. Karch⁴, L. Antiga⁵, D. Debray⁶, L. Hierro⁷, D. Kelly⁸, V. McLin⁹, E. Nicastro⁵, J. Pawlowska¹⁰, R. Mikolajczyk¹¹, U. Baumann¹², C. Falk¹³
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Institute of Transplant Immunology, MHH, Hannover, Germany, ³Division of Pediatric Gastroenterology and Hepatology, MHH; European Paediatric Liver Transplantation Network, Hannover, Germany, ⁴Research Group Epidemiological and Statistical Methods, Helmholtz Centre for Infection Research, Braunschweig; German Center for Infection Research, TTU-IICH Hannover; Institute for Epidemiology and Social Medicine, University of Münster, Münster, Germany, ⁵Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Hôpital Necker-Enfants Malades, Paris, France, ⁷Hospital Infantil Universitario La Paz, Madrid, Spain, ⁸Birmingham Children's Hospital, Birmingham, United Kingdom, ⁹Service Spécialités Pédiatriques, Genève, Switzerland, ¹⁰Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw, Poland, ¹¹German Center for Infection Research, TTU-IICH Hannover; Institute of Medical Epidemiology, Biostatistics and Medical Informatics, University of Halle, Halle, Germany, ¹²Division of Pediatric Gastroenterology and Hepatology, MHH; Birmingham Children’s Hospital, UK; European Paediatric Liver Transplantation Network, Hannover, Germany, ¹³Institute of Transplant Immunology, MHH; German Center for Infection Research, TTU-IICH, Hannover, Germany
*Purpose: In the European multicentre “ChilSFree” study we aimed to identify soluble and cellular biomarkers in blood of various end-stage diseases before pLTx.*Methods: Using flow…
2022 American Transplant Congress
Alloprimed Antibody-Suppressor CD8⁺ TCells Preferentially Kill Alloprimed Germinal Center B Cells
J. Zimmerer, S. Chaudhari, G. Bumgardner
OSUWMC, Columbus, OH
*Purpose: Antibody-mediated rejection (AMR) is a significant contributor to transplant rejection. Our prior work identified a novel subset of CXCR5+CD8+ T cells (CD8+ TAb-supp cells)…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Human Renal Allograft Rejection Demonstrates Distinct Transcriptomic Profiles That Vary Based on the Type of Maintenance Immunosuppression
T. Shi¹, A. Burg¹, K. Roskin², J. Rush³, B. Haraldsson³, A. Shields⁴, R. Alloway⁴, E. Woodle⁵, D. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Novartis Pharmaceuticals AG, Basel, Switzerland, ⁴Internal Medicine, University of Cincinnati, Cincinnati, OH, ⁵Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Rejection therapy has remained unchanged for 60 years and is associated with significant failure and infection rates. Development of new anti-rejection therapies requires mechanistic…
2022 American Transplant Congress
Portal Vein Challenges in Pediatric Liver Transplantation: The Utility of Interposition Grafts as an Acceptable Management Strategy
K. Etesami¹, R. Hogen², J. Cervantes³, Y. Kwon⁴, S. Zielsdorf³, J. Emamaullee³, Y. Genyk³
¹Surgery, Children's Hospital Los Angeles, Los Angeles, CA, ²University of Southern California, West Hollywood, CA, ³University of Southern California, Los Angeles, CA, ⁴Hepatobiliary and Abdominal Transplant Surgery, University of Southern California, Los Angeles, CA
*Purpose: Portal vein (PV) anomalies and portal vein thrombosis (PVT) can present as challenging cases in the pediatric cohort, necessitating analysis and an algorithmic approach.*Methods:…
2022 American Transplant Congress
Anti-Fibrotic Property of Adipose Derived Regenerative Cells on Hydrogen Peroxide Induced Injury in Nrk-52e Cells
R. Chawangwongsanukun¹, R. Lathan¹, R. Pearson², M. Clancy², P. Mark¹
¹Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom, ²Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom
*Purpose: Adipose derived regenerative cells (ADRCs) are a heterogenous cell population derived from adipose tissue. These cells are composed of endothelial progenitor cells, pericytes, and…
2022 American Transplant Congress
Urinary Exosomal MicroRNA Biomarkers for Antibody-Mediated Rejection After Kidney Transplantation
S. Shin, M. Kim, S. Lim, H. Kwon, J. Jung, Y. Ko, H. Kwon, Y. Kim
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
*Purpose: We aimed to identify urine-derived exosomal miRNAs as diagnostic biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: Exosomal miRNAs using differential ultracentrifugation were isolated…
2022 American Transplant Congress
Impact of Belatacept on Clinical Outcomes in Lung Transplant Patients with Antibody-Mediated Rejection
L. Zaffiri, R. Hallak, S. Leonard, M. Neely, A. Hulber, H. Berry, K. A. Young, J. M. Reynolds
Duke University, Durham, NC
*Purpose: Antibody-mediated rejection (AMR) is cause of significant morbidity and mortality in lung transplant recipients (LTRs). An optimal therapeutic regimen is still lacking. Recent evidence…
2022 American Transplant Congress
The Role of T Lymphocyte Subsets in Kidney Transplantation
L. Vagiotas¹, A. Xochelli², E. Sampani³, V. Nikolaidou², D. Asouchidou², E. Kasimatis³, N. Antoniadis¹, M. Daoudaki⁴, M. Stangou³, A. Papagianni³, G. Tsoulfas¹, A. Fylaktou²
¹Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ²National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, ³Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ⁴Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece
*Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…
2022 American Transplant Congress
Patient Outcomes After Heart and Double Lung Transplant from a Single High-Volume Center
R. P. Brumer¹, A. Goodarzi², R. Chihara¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: Combined heart and double-lung transplant (OHT/DLT) is a relatively uncommon procedure, and patient outcomes after undergoing OHT/DLT are therefore not as well understood as…