Am J Transplant, Volume 22, Suppl 3 Archives - Page 165 of 190 - ATC Abstracts

2022 American Transplant Congress
PACAP-Mediated Autophagy Prevents Liver Ischemia Reperfusion Injury in OLT
Z. Xue, B. Yang, R. Busuttil, J. Kupiec-Weglinski, H. Ji
UCLA Medical Center, Los Angeles, CA
*Purpose: Pituitary adenylate cyclase-activating polypeptide (PACAP) is from vasoactive intestinal peptide-glucagon-secretin family. Our group was the first to demonstrate that neuropeptide PACAP, which innervates the…
2022 American Transplant Congress
Antibody Response to 3-Dose SARS-CoV-2 mRNA Vaccination in Pediatric Solid Organ Transplant Recipients
C. X. Qin¹, S. R. Auerbach², O. Charnaya¹, L. A. Danziger-Isakov³, N. H. Ebel⁴, A. G. Feldman², E. K. Hsu⁵, J. McAteer¹, S. Mohammad⁶, E. R. Perito⁷, A. M. Thomas¹, T. P. Chiang¹, J. M. Garonzik-Wang¹, D. L. Segev¹, D. B. Mogul¹
¹Johns Hopkins University, Baltimore, MD, ²University of Colorado, Aurora, CO, ³University of Cincinnati, Cincinnati, OH, ⁴Stanford University, Palo Alto, CA, ⁵University of Washington, Seattle, WA, ⁶Northwestern University, Chicago, IL, ⁷University of California San Francisco, San Francisco, CA
*Purpose: We report the immunogenicity and safety of a third BNT162b2 vaccine in pediatric solid organ transplant recipients (pSOTRs).*Methods: Samples from pSOTRs (12-18 years) enrolled…
2022 American Transplant Congress
Successful Kidney Transplantation from a Deceased Donor with Severe COVID-19: Undetectable SARS-CoV-2 in Donor Kidney and Aorta by Sensitive Molecular Testing
K. Lee¹, N. M. Desai¹, J. Resnick², M. Li², A. Johanson¹, A. Pekosz², H. Rabb¹, J. L. Mankowski¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
*Purpose: Kidney transplantation (KT) from coronavirus disease 2019 (COVID-19) positive donors has been avoided due to concerns for donor-derived transmission and possibility of the kidney…
2022 American Transplant Congress
Analysis and Outcomes of Liver Re Transplantation After Initial DCD Liver Transplantation
A. Kadimella¹, J. Eason², R. Helmick², J. Vanatta²
¹HPB and Liver Transplantation, AIG Hospitals, Hyderabad, India, ²University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: DCD livers were more prone for ischemic cholangiopathy and graft failure than DBD livers due to multi factorial reasons. With all the available data…
2022 American Transplant Congress
Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health
M. Rao¹, M. Amouzgar¹, J. T. Harden¹, M. Lapasaran¹, A. Trickey¹, B. Armstrong², J. Odim³, T. Debnam³, C. Esquivel¹, S. C. Bendall¹, O. Martinez¹, S. M. Krams¹
¹Stanford University, Palo Alto, CA, ²Rho, Durham, NC, ³National Institutes of Health, Bethesda, MD
*Purpose: Solid organ transplant is lifesaving for children with end-stage heart, liver, or kidney disease. Protection of the transplanted organ from rejection requires long-standing immunosuppression.…
2022 American Transplant Congress
Post-Kidney Transplant Body Mass Index Trajectories Are Associated with Graft Loss and Mortality
Y. Liu¹, V. Bendersky¹, X. Chen¹, M. Harhay², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins University, Baltimore, MD, ²Drexel University, Philadelphia, PA
*Purpose: Early post-kidney transplantation (KT) changes in physiology, medications, and health stressors likely impact body mass index (BMI). Hence, we sought to estimate trajectories of…
2022 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Covid-19 in Singapore Treated with Sotrovimab in the Era of the Delta Variant
M. R. D'Costa¹, H. K. Sran¹, E. Wong¹, Z. Chang², Y. Chua², J. Somani³, L. Lum³, A. Vathsala¹
¹National University Centre for Organ Transplantation, National University Hospital, Singapore, Singapore, ²Medicine, National University Hospital, Singapore, Singapore, ³Infectious Diseases, National University Hospital, Singapore, Singapore
*Purpose: Kidney transplant recipients (KTRs) are at higher risk for severe COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Sotrovimab decreases the risk…
2022 American Transplant Congress
Outcomes of COVID-19 in Solid Organ Transplant Recipients in Canada 2020-2021: A Prospective, Multicenter Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³UMontreal, Montreal, QC, Canada, ⁴StMH, Toronto, ON, Canada, ⁵Laval U, Quebec, QC, Canada, ⁶UCalgary, Calgary, AB, Canada, ⁷USaskatchewan, Saskatoon, SK, Canada, ⁸HMR, Montreal, QC, Canada, ⁹McGill U, Montreal, QC, Canada, ¹⁰SCH, Edmonton, AB, Canada
*Purpose: To understand the outcomes and changes in disease severity of COVID-19 in Solid Organ Transplant (SOT) recipients over time in the context of therapeutic…
2022 American Transplant Congress
Proteinuria in Diseased Kidney Transplant Donors for Prediction of Chronic Lesions in Pre-Transplant Biopsies – A Prospective Observational Study
F. Haupenthal¹, J. Kläger², F. Bauernfeind³, A. Heinzel¹, K. Doberer¹, K. Mayer¹, L. Naar¹, M. Eigenschink¹, K. Hu¹, H. Regele², T. Szekeres⁴, R. Reindl-Schwaighofer¹, G. Bond¹
¹Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Department of Pathology, Medical University of Vienna, Vienna, Austria, ³Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, Sweden, ⁴Division of Clinical Chemistry, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
*Purpose: Pre-transplant kidney graft biopsies have been suggested for organ quality assessment. Data on the association between donor proteinuria and organ quality of deceased donors…
2022 American Transplant Congress
Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA
R. Lopez-Soler¹, X. Ding², Q. Zang³
¹Tansplant, Surgery, Edward Hines VA Medical Center, Hines, IL, ²Pathology, Loyola University Medical Center, Maywood, IL, ³Surgery, Loyola University Medical Center, Maywood, IL
*Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…