Am J Transplant, Volume 22, Suppl 3 Archives - Page 164 of 190 - ATC Abstracts

2022 American Transplant Congress
Ixazomib for Desensitization (IXADES): Results of a Phase II Clinical Trial
N. Wilson¹, S. R. Reese², L. Ptak³, F. Aziz², S. Parajuli², V. Jucaud⁴, S. Denham⁴, A. Mishra⁵, P. Hematti⁵, A. Djamali²
¹University of Wisconsin, Madison, WI, ²Medicine, University of Wisconsin, Madison, WI, ³Administration, University of Wisconsin, Madison, WI, ⁴Terasaki Institute, Los Angeles, CA, ⁵UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI
*Purpose: Ixazomib is a second-generation oral proteasome inhibitor, FDA approved for the treatment of refractory multiple myeloma. The purpose of the study was (1) to…
2022 American Transplant Congress
Internal Validation of a Pre-Transplant Biomarker Panel to Predict Post-Transplant Mortality: The Liver Immune Frailty Index
G. G. Panayotova¹, D. T. Nguyen², E. A. Graviss², L. J. Minze², S. Simonishvili¹, Y. Qin¹, T. Ayorinde¹, G. Prakash¹, F. Paterno¹, L. Brown¹, A. Amin¹, X. C. Li², R. M. Ghobrial², J. V. Guarrera¹, K. E. Lunsford¹
¹Rutgers New Jersey Medical School, Newark, NJ, ²Houston Methodist Hospital, Houston, TX
*Purpose: Infection and sepsis are the greatest contributors to early post-liver transplant (LT) mortality. These often result from ongoing immune dysfunction, or “Immune Frailty”. We…
2022 American Transplant Congress
Immune Cell Phenotype of Acute Rejection of Pancreas Allografts by RNA Sequencing Analysis
C. Hughes, H. Yang, C. Snopkowski, C. Li, D. M. Dadhania, S. Sultan, C. Hartono, M. Suthanthiran, S. V. Seshan, T. Muthukumar
Weill Cornell Medicine, New York, NY
*Purpose: Long term survival of pancreas allografts are inferior to kidney allografts. Molecular mechanisms underpinning pancreas allograft rejection and failure have not been explored in…
2022 American Transplant Congress
Seeing is Believing: Efficacy of a Video-Based Intervention in Improving Skin Cancer Risk Awareness and Preventative Strategies Among Solid Organ Transplant Recipients
R. Saranath, J. Gomez, E. Shah, S. Michalak, R. Haughton, B. Fernandez, I. Ahronowitz
USC Keck School of Medicine, Los Angeles, CA
*Purpose: Despite improvement in their overall life expectancy, solid organ transplant recipients (SOTRs) remain at elevated risk of developing non-melanoma skin cancers. Moreover, patients of…
2022 American Transplant Congress
Clinical Validation of Automated Urinary Chemokine Assays for Non-Invasive Detection of Kidney Transplant Rejection: A Large Prospective Cohort Study
E. Van Loon¹, C. Tinel¹, J. Callemeyn¹, M. Coemans¹, A. Van Craenenbroeck¹, T. Vaulet², D. Anglicheau³, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²ESAT STADIUS Center for Dynamical Systems, KU Leuven, Leuven, Belgium, ³Department of Nephrology and Kidney Transplantation, Necker Hospital, Paris, France
*Purpose: Non-invasive diagnostic markers for kidney transplant rejection can provide useful information but often do not reach the clinical implementation stage. The chemokines CXCL9 and…
2022 American Transplant Congress
Lymphotoxin Beta Receptor Classical NFkB Signaling in Lymphatic Endothelial Cells Drives Treg Tissue Stability
V. Saxena¹, W. Piao¹, L. Li¹, M. W. Shirkey¹, R. Lakhan¹, S. Walden², K. L. Hippen², B. Blazar², J. S. Bromberg¹
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Minnesota, Minneapolis, MN
*Purpose: Regulatory T cell (Treg) suppressor function and allograft protection depend on maintenance of transcription factor Foxp3 expression and lymphatic migration, respectively. Treg lymphotoxin (LT)…
2022 American Transplant Congress
Testing an Education Only Intervention to Increase Willingness and Pursuit of Living Donor Kidney Transplantation
J. Loor¹, Y. Leyva¹, E. Croswell², M. Dew², L. Boulware³, L. Myaskovsky¹
¹University of New Mexico, Albuquerque, NM, ²University of Pittsburgh, Pittsburgh, PA, ³Duke, Durham, NC
*Purpose: The Talking About Live Kidney Donation (TALK) intervention uses an educational video and booklet to improve consideration and pursuit of LDKT in kidney failure…
2022 American Transplant Congress
Racial and Immunologic Disparities Impact Access to Repeat Kidney Transplantation Among Patients with Previous Failed Kidney Allograft
B. P. Lovasik¹, R. Zhang¹, R. Lynch¹, R. Patzer¹, A. Adams²
¹Emory University, Atlanta, GA, ²University of Minnesota, Minneapolis, MN
*Purpose: The number of patients with a failed kidney transplant who are being considered for retransplantation is increasing steadily. However, disparities in access to repeat…
2022 American Transplant Congress
The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation
K. Evans¹, K. Beermann¹, H. Lee², M. Harris¹, C. W. Frankel³, H. Berry¹, H. Ali³
¹Pharmacy, Duke Health, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC
*Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…
2022 American Transplant Congress
Evolution of Cellular and Humoral Immunity During and After a Three Doses-Course of mRNA-1273 COVID-19 Vaccine in Kidney Transplant Recipients
D. Cucchiari¹, N. Egri¹, J. Casals-Urquiza², J. Del Risco-Zevallos¹, D. Rodríguez-Espinosa³, E. Montagud-Marrahi², J. Rovira⁴, M. Ramirez-Bajo⁵, E. Banón-Maneus⁵, P. Ventura-Aguiar², M. Pascal¹, I. Revuelta⁶, B. Bayès², F. Diekmann²
¹Hospital Clínic de Barcelona, Barcelona, Spain, ²Hospital Clinic de Barcelona, Barcelona, Spain, ³Nephrology and Renal Transplantation, Hospital Clinic of Barcelona, Barcelona, Spain, ⁴Laboratori Experimental de Nefrologia i Trasplantament (LENIT), IDIBAPS, Barcelona, Spain, ⁵IDIBAPS, Barcelona, Spain, ⁶Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain
*Purpose: Seroconversion after a 2 doses of mRNA COVID-19 vaccine in kidney transplant recipients (KTR) ranges between 30 and 50% in different series. We previously…