Am J Transplant, Volume 22, Suppl 3 Archives - Page 157 of 190 - ATC Abstracts

2022 American Transplant Congress
Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA
R. Lopez-Soler¹, X. Ding², Q. Zang³
¹Tansplant, Surgery, Edward Hines VA Medical Center, Hines, IL, ²Pathology, Loyola University Medical Center, Maywood, IL, ³Surgery, Loyola University Medical Center, Maywood, IL
*Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…
2022 American Transplant Congress
Dynamic Changes and Roles of Specialized Pro-resolving Lipid Meditators in the Initiation and Resolution Process of Lung Ischemia-Reperfusion Injury in Rats
H. Oda¹, S. Tanaka¹, M. Shinohara², Y. Morimura¹, Y. Yokoyama¹, H. Kayawake¹, Y. Yamada¹, A. Ohsumi¹, D. Nakajima¹, H. Date¹
¹Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto City, Japan, ²The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe City, Japan
*Purpose: Lung ischemia-reperfusion injury (IRI) is one of the significant complications after lung transplantation, which is a form of acute lung injury by robust inflammation.…
2022 American Transplant Congress
Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers
V. Fleetwood¹, D. Axelrod², Y. Caliskan¹, H. Randall¹, J. Wellen³, M. Lichtenberger³, C. Dedert¹, R. Rothweiler⁴, G. F. Marklin⁴, D. Brockmeier⁴, M. A. Schnitzler¹, S. A. Husain⁵, S. Mohan⁵, B. Kasiske⁶, M. Cooper⁷, K. L. Lentine¹
¹Saint Louis U., St. Louis, MO, ²U. of Iowa, Iowa City, IA, ³WUSTL, St. Louis, MO, ⁴Mid-Am. Trans., St. Louis, MO, ⁵Columbia U., New York, NY, ⁶Hennepin Healthcare, Minneapolis, MN, ⁷MedStar Transpl. Inst., Washington, DC
*Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…
2022 American Transplant Congress
The Role Of Ferroptosis In Modulating Ischemia Reperfusion Injury(IRI) Gene Expression In Marginal Donor Livers(MDLS) Using The Novel Protect Normothermic Perfusion Pump
M. D. Nazzal¹, K. Kurashima², J. Bettag², A. Chen², S. Bruno², A. Nagarapu², J. Van Nispen¹, J. Krebs², J. Teckman², D. Carpenter³, D. Hermelin³, C. Varma¹, A. Jain²
¹Surgery, Saint Louis University, Saint Louis, MO, ²Pediatrics, Saint Louis University, Saint Louis, MO, ³Pathology, Saint Louis University, Saint Louis, MO
*Purpose: Severe IRI can impair liver allograft when using MDLs and accounts for high discard rates. We tested iron chelators to reduce ferroptosis and IRI.…
2022 American Transplant Congress
Comparing The Immunologic Responses Between Kidney Transplant Recipients Receiving Standard Immunosuppression And CNI Reduction After Two Doses Of ChAdOx-1 And A Booster Dose BNT162b2
S. Phirom¹, T. Kitrungphaiboon², W. Jantarabenjakul², Y. Avihingsanon², W. Prasithsirikul³, J. Vanichanan⁴, P. Hansasuta⁵, N. Townamchai⁶
¹Nephrology division, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, ²King Chulalongkorn Memorial Hospital, Bangkok, Thailand, ³Bamrasnaradura infectious disease institute, Bangkok, Thailand, ⁴Infectious diseases, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, ⁵Department of Microbiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, ⁶Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand
*Purpose: Immunosuppression can impair immunological responses after vaccination in kidney transplant recipients (KTR). However, little is known about the effect of the booster dose of…
2022 American Transplant Congress
Reproductive Counseling in Kidney Transplant: Patient Needs and Current Practices
S. Rajagopal¹, J. Ritchie², D. Seidman³, Y. Srisengfa⁴, E. R. Perito⁵, D. Adey⁶, M. Sarkar⁷
¹Internal Medicine, Brookdale University Hospital, Brooklyn, NY, ²Obstetrics and Gynecology, St Luke's University Health Network, Bethlehem, PA, ³Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵Pediatric GI/Hepatology, University of California San Francisco, San Francisco, CA, ⁶Nephrology, University of California San Francisco, San Francisco, CA, ⁷GI/Hepatology, University of California San Francisco, San Francisco, CA
*Purpose: Nearly 20% of female kidney transplant (KT) recipients are reproductive-aged. Early/unplanned pregnancies post-KT increase maternal and fetal risks, though data on reproductive counseling in…
2022 American Transplant Congress
Induction Immunosuppression Does Not Worsen Tumor Recurrence After Liver Transplantation for T2 Hepatocellular Carcinoma and May Allow for Decreased Mortality
C. Durkin¹, T. Bittermann¹, D. E. Schaubel²
¹Gastroenterology, University of Pennsylvania, Philadelphia, PA, ²Biostatistics, University of Pennsylvania, Philadelphia, PA
*Purpose: Prior studies have suggested that induction therapy leads to worse outcomes after liver transplantation (LT) for hepatocellular carcinoma (HCC). This study evaluated the impact…
2022 American Transplant Congress
Maribavir (MBV) versus Investigator-Assigned Therapy (IAT) for Refractory Cytomegalovirus (CMV) Infection (with or without Resistance) in Solid Organ Transplant (SOT) Recipients: Subgroup Safety Analysis of a Phase 3 Study
R. M. La Hoz¹, D. Florescu², D. Kumar³, F. Saliba⁴, J. Gu⁵, A. Sundberg⁵
¹Univ. Texas Southwestern Medical Center, Dallas, TX, ²Univ. Nebraska Medical Center, Omaha, NE, ³Univ. Health Network, Toronto, ON, Canada, ⁴Univ. Paris Saclay, Paris, France, ⁵Takeda Development Center Americas, Inc., Lexington, MA
*Purpose: In a Phase 3 study of MBV vs IAT (val/ganciclovir, foscarnet, or cidofovir) for refractory CMV infection (with/without resistance; R/R) in hematopoietic cell transplant…
2022 American Transplant Congress
Association of Native Kidney Disease with De Novo Cancer Development After Kidney Transplant
Y. Caliskan¹, D. Axelrod², R. Li¹, W. Cheungpasitporn³, M. Schnitzler¹, M. McAdams DeMarco⁴, J. Ahn⁴, T. Alhamad⁵, H. Randall¹, S. Bae⁴, D. Segev⁴, K. L. Lentine¹
¹Saint Louis University, Saint Louis, MO, ²University of Iowa, Iowa City, IA, ³Mayo Clinic, Rochester, MN, ⁴John Hopkins University, Baltimore, MD, ⁵Washington University in Saint Louis, Saint Louis, MO
*Purpose: Primary glomerulonephritis (GN) and congenital anomalies of the kidney and urinary tract (CAKUT) have been shown to be associated with cancer development in the…
2022 American Transplant Congress
Histocompatibility Findings in the First Xenotransplants from a Pig to Deceased Human Recipient
M. Mangiola, V. Tatapudi, J. Stern, Z. Stewart Lewis, B. Lonze, N. Ali, R. Montgomery
Transplant Institute, NYU Langone Transplant Institute, New York, NY
*Purpose: Humans lack α-1,3-Gal (α-gal) epitopes, and naturally occurring α-gal antibodies (Abs) cause hyperacute rejection of porcine xenografts. We conducted 2 successful xenotransplants in brain-dead…