Am J Transplant, Volume 22, Suppl 3 Archives - Page 155 of 190 - ATC Abstracts

2022 American Transplant Congress
The Ties That Transplant: The Social Network Determinants of the Living Kidney Donor Relationship Distribution
J. Daw
Sociology & Criminology, The Pennsylvania State University, University Park, PA
*Purpose: To describe and explain the distribution of social relationships of living kidney donors to kidney transplant recipients.*Methods: Using an original dataset of transplant candidates…
2022 American Transplant Congress
Impact of Biliary Reconstruction on Tacrolimus Absorption in Pediatric Liver Transplant
M. Chandran¹, D. Yoeli¹, A. Sater², M. Adams¹, F. Karrer¹
¹Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
*Purpose: Tacrolimus (FK506) oral bioavailability in pediatric liver transplant recipients (LTR) is poor. Enteral FK506 is primarily absorbed in the small intestine and subject to…
2022 American Transplant Congress
Lipid Metabolism Profile of Human Kidneys During Ex Vivo Normothermic Perfusion
J. Yu, I. Palma, S. Adams, J. Sageshima, P. Than, R. Perez
UC Davis Medical Center, Sacramento, CA
*Purpose: The kidney is a highly metabolic organ and lipids are an important energy source. In this study, we examined the lipid profiles of discarded…
2022 American Transplant Congress
Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury
D. Xu¹, X. Qu¹, Y. Tian¹, M. Sheng¹, Y. Lin¹, Y. Zhan¹, F. M. Kaldas¹, R. W. Busuttil¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹, Q. Xia², B. Ke¹
¹Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA, ²Liver Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China
*Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
2022 American Transplant Congress
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
R. A. Sosa¹, T. Mone², B. V. Naini¹, D. B. Kohn³, E. F. Reed¹, K. Wheeler², B. Campo-Fernandez³, A. Davila³, D. J. Chaffin⁴, J. DiNorcia⁵, F. M. Kaldas⁵, A. Cohen², E. Lum⁶, J. L. Veale⁷, N. M. Kogut⁷
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²One Legacy, Los Angeles, CA, ³Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, ⁴LifeStream Blood Bank, San Bernadino, CA, ⁵Surgery, UCLA, Los Angeles, CA, ⁶Medicine, UCLA, Los Angeles, CA, ⁷Urology, UCLA, Los Angeles, CA
*Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
2022 American Transplant Congress
Reduced CD45RA-CCR7- Tregs Subtypes in Highly Sensitised Patients Associates with a Failure to Regulate Memory IFNγ Production in Response to Donor Alloantigens
C. Dudreuilh¹, S. Basu¹, O. Shaw², H. Burton¹, C. Domingo-Vila¹, T. Tree¹, G. Lombardi¹, C. Scotta¹, A. Dorling¹
¹King's College London, London, United Kingdom, ²Viapath Clinical Transplantation Laboratory, Guy's Hospital, London, United Kingdom
*Purpose: Highly sensitised (HS) patients exhibit worse long-term outcomes after kidney transplantation compared to non-sensitised patients. It has been hypothesised that regulatory T cells (Tregs)…
2022 American Transplant Congress
Spectrum of Pre-Transplant Esophagram Abnormalities and Association with Long-Term Outcomes
I. Lill¹, D. Lovin², A. C. Lawrence², M. Mohanka², J. Joerns², S. Bollineni², I. L. Timofte², V. Kaza², M. Wait³, F. Torres², A. Banga²
¹University of Texas - Southwestern, Dallas, TX, ²Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas - Southwestern, Dallas, TX, ³Cardiovascular & Thoracic Surgery, University of Texas - Southwestern, Dallas, TX
*Purpose: To determine the frequency and type of esophageal abnormalities on screening esophagram during the pre-transplant evaluation and evaluate the association of these abnormalities on…
2022 American Transplant Congress
Variability In Plasma Donor-derived Cell-free DNA Levels With CLAD More Than 5-years After Lung Transplantation: Pilot Data
D. Levine¹, D. Ross²
¹Department of Medicine, University of Texas, San Antonio, San Antonio, TX, ²Natera, Inc., Ausin, TX
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been clinically validated for detection of acute rejection (AR) in lung transplant (LT) although studies have typically focused on…
2022 American Transplant Congress
Predictors Associated with Survival Outcomes for DCD and DBD Renal Transplants from D4 Donors. A Registry Based Machine Learning Analysis (MLA)
H. Sharma¹, A. Sharma²
¹Royal Liverpool University Hospital, Liverpool, United Kingdom, ²Loyola University Chicago, Loyola University Chicago, IL
*Purpose: Marginal Donor 4- D4 ( Donor Risk Index ≥1.50 ) Matching was introduced as a part of new Kidney allocation scheme in the UK…
2022 American Transplant Congress
Long-Term Outcomes After Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant: A Matched Cohort Study
G. Divard, C. Debiais, C. Legendre, O. Aubert, C. Lefaucheur, A. Loupy
Paris Transplant Group, INSERM, Paris, France
*Purpose: Conversion to belatacept after transplant seems to be safe. However, no studies have reported the long-term efficacy and safety outcomes after conversion to belatacept…