Am J Transplant, Volume 22, Suppl 3 Archives - Page 151 of 190 - ATC Abstracts

2022 American Transplant Congress
Poor Outcomes in Patients with Transplant Glomerulopathy Independent of Banff Categorization or Therapeutic Interventions
K. Wu¹, D. Schmidt¹, C. Lopez del Moral¹, Q. Zhang¹, F. Halleck¹, M. G. Naik¹, N. Lachmann², B. Rudolph³, K. Budde¹
¹Department of Nephrology, Charite Campus Mitte, Berlin, Germany, ²Institut für Transfusionsmedizin, Charite Virchow Klinikum, Berlin, Germany, ³Institut für Pathologie, Charite Campus Mitte, Berlin, Germany
*Purpose: Banff classification is an accepted diagnostic tool, but also used as a tool to define endpoints in clinical trials. There is a need to…
2022 American Transplant Congress
Membrane Attack Complex as a More Sensitive Tool to Evaluate Complement Activation in Kidney Transplant Recipients with Donor-Specific Antibodies
C. Arias-Cabrales, D. Redondo-Pachón, E. Rodríguez, M. Riera, A. Buxeda, M. Pérez-Sáez, C. Burballa, L. Llinas, J. Pascual, M. Crespo
Nephrology, Hospital del Mar, Barcelona, Spain
*Purpose: Kidney transplant recipients with late HLA donor-specific antibodies (DSA) detected with single antigen beads (SAB) exhibit more frequent antibody-mediated rejection (ABMR) and graft loss.…
2022 American Transplant Congress
Pediatric Liver Transplant Factors That Influence Tacrolimus Absorption
M. Chandran¹, D. Yoeli¹, A. Sater², F. Karrer¹, M. Adams¹
¹Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
*Purpose: The aim of this study was to investigate the association between various pediatric recipient characteristics at time of liver transplant and FK506 absorption 6…
2022 American Transplant Congress
Identification of Akkermansia Muciniphila and Bacteroides Thetaiotaomicron Associated with the Alleviation of Peritransplant Liver Damage in Mouse Recipients
K. Dery¹, H. Kojima², H. Hirao², K. Kadono³, T. Dong², J. Kupiec-Weglinski⁴
¹Surgery, UCLA, Los Angeles, CA, ²UCLA, Los Angeles, CA, ³Liver Transplant Surgery, UCLA, Los Angeles, CA, ⁴UCLA Medical Center, Los Angeles, CA
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
2022 American Transplant Congress
Fixed-Dose Rituximab for Pre-Transplant DSA in Kidney Transplant Recipients
K. Progar¹, K. Kurwicki², N. Nesselhauf³, J. Hagopian⁴, S. January⁵, H. Wijeweera⁶, M. McCloskey⁷, M. Merzkani⁸, R. Delos Santos⁹
¹Transplant, Barnes-Jewish Hospital, St. Louis, MO, ²SSM Health Saint Louis University Hospital, Saint Louis, MO, ³Barnes-Jewish Hospital, Edwardsville, IL, ⁴Pharmacy, University of Michigan, Ann Arbor, MI, ⁵Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, ⁶Washington University, Saint Louis, MO, ⁷Barnes-Jewish Hospital, St. Louis, MO, ⁸Washington University, St Louis, MO, ⁹Transplant, Washington University, St. Louis, MO
*Purpose: Donor specific antibodies (DSAs) occur in 15-30% of kidney transplant recipients (KTRs) and are associated with rejection and graft loss. Rituximab (RTX), an antiCD20…
2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
W. Burlingham¹, E. Jankowska-Gan², J. Fechner³, C. Little², J. Sullivan⁴, D. Foley¹
¹University of Wisconsin, Madison, WI, ²Surgery-Transplant Division, University of Wisconsin, Madison, WI, ³Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, ⁴Surgery, University of Wisconsin, Madison, WI
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…
2022 American Transplant Congress
Characterization of GZMB+ Bregs Transcriptome and Their Impact on Target Cells in Single-Cell RNA-seq
N. Sailliet, H. Le Mai, A. Dupuy, F. Cynthia, M. Chesneau, J. Poschmann, R. Danger, S. Brouard
CRTI- INSERM UMR 1064, Nantes, France
*Purpose: During the inflammatory process, the immune system capacity to regulate itself is mandatory to balance effector positive feedback, avoid allergies and autoimmunity. Different subsets…
2022 American Transplant Congress
Impact of the Weekend Effect on Adult and Pediatric Liver or Kidney Offer Acceptance
T. Yamamoto, M. Fruscione, A. Shah, L. Dageforde, S. Kimura, H. Yeh, N. Elias, T. Kawai, J. F. Markmann
Transplant Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Weekends may impose resource and manpower constraints on hospitals. Studies using data from prior allocation schemas showed increased adult organ discards on weekends. We…
2022 American Transplant Congress
dd-cfDNA Varies Among Diagnostics Groups of Pulmonary AMR
D. Levine¹, C. Giner¹, C. Pham², R. Woodward³, A. Roux⁴
¹University of Texas Health System San Antonio, San Antonio, TX, ²CareDX, South San Francisco, CA, ³CareDx, South San Francisco, CA, ⁴Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France
*Purpose: Antibody mediated rejection (AMR) in lung transplant remains complex, with differential diagnosis often overlapping with other causes of lung dysfunction. Diagnostic certainty declines to…
2022 American Transplant Congress
Pooled Prevalence of Pulmonary Embolism in Lung Transplant Recipients – A Meta-Analysis
F. Pyarali, A. Stevens, R. Rampolla
Department of Pulmonary and Critical Care, Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Similar to other operations, lung transplantation surgery has been associated with an increased risk of venous thromboembolism. While various studies have aimed to estimate…