Am J Transplant, Volume 22, Suppl 3 Archives - Page 151 of 190 - ATC Abstracts

2022 American Transplant Congress
Donor-Derived Cell-Free DNA Trends Before and After Rejection Vary Based on Timing of Rejection
C. Rebello¹, K. Guo¹, S. Park², B. Kinsella¹, L. Zhao¹, J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been used for acute rejection detection and trending levels may help predict future rejection and assess the adequacy of…
2022 American Transplant Congress
Impact of Varying Levels of Normal Range Baseline Donor Derived Cell Free DNA on Medium-Term Outcomes Following Kidney Transplantation
K. K. Sureshkumar¹, A. Grazier², B. Chopra¹
¹Nephrology, Medicine Institute, Allegheny General Hospital, Pittsburgh, PA, ²Abdominal Transplantation, Allegheny General Hospital, Pittsburgh, PA
*Purpose: Donor derived cell free DNA (dd-cfDNA) is a biomarker with high negative predictive value for ruling out acute rejection (AR) in kidney allografts. Baseline…
2022 American Transplant Congress
Impact of HLA Matching on Graft Survival in Kidney Transplant Recipients
J. Miller¹, N. Salkowski¹, B. Thompson¹, R. Kandaswamy², P. Stock³, A. Israni¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, ³Department of Surgery, University of California San Francisco, San Francisco, CA
*Purpose: This study aims to estimate the association of HLA matching at the A, B, DR, and DQ loci with posttransplant graft failure and patient…
2022 American Transplant Congress
The Evolution of Hypogammaglobulinemia in Kidney Transplant Recipients and Its Associated Risk Factors
E. Jo¹, S. Min², A. Han³
¹Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ²Surgery, Seoul National University College of Medicine, Seoul, Kosovo, Republic of, ³Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Hypogammaglobulinemia (HGG) has been extensively studied to identify a biological marker for infection. According to Florescu et al. (2013), a meta-analysis of 18 clinical…
2022 American Transplant Congress
The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients
S. Park¹, M. Kandpal², K. Guo², S. Kleiboeker³, R. Sinha⁴, M. Abecassis⁵, J. Levitsky⁶
¹Transplant nephrology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Eurofins Viracor, Lee's Summit, MO, ⁴Eurofins Viracor, Lee's summit, MO, ⁵University of Arizona, Tucson, AZ, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: In our previous studies, blood-based gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) have been independently validated in liver transplant recipients (LTR) to…
2022 American Transplant Congress
Single Blind Randomized Controlled Trial Comparing BNT162b2 Vs JNJ-78436735 Vaccine As An Additional Dose After Two Doses Of BNT162b2 Vaccine In Solid Organ Transplant (SOT) Recipients
Y. Natori¹, E. Martin², A. Mattiazzi³, J. Bini Viotti¹, K. S. Ortecho⁴, S. Pallikkuth⁵, S. Anjan¹, J. Simkins¹, G. Guerra³
¹Department of Medicine, Division of Infectious Diseases, University of Miami, Miami, FL, ²Department of Medicine, Division of Hepatology, University of Miami, Miami, FL, ³Department of Medicine, Division of Nephrology, University of Miami, Miami, FL, ⁴Miami Transplant Institute, Jackson Health System, Miami, FL, ⁵University of Miami, Miami, FL
*Purpose: Even though a high efficacy and immunogenicity of COVID-19 vaccines have been reported in the general population, vaccine immunogenicity is suboptimal in SOT recipients…
2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Immune Cell Profile in Kidney Allograft Fibrosis
J. McDaniels¹, A. Shetty¹, C. Kuscu², C. Kuscu², T. Rousselle¹, E. Bardhi¹, C. Drachenberg¹, M. Talwar², J. Eason², T. Muthukumar³, D. Maluf¹, V. Mas¹
¹University of Maryland Baltimore, Baltimore, MD, ²UTHSC, Memphis, TN, ³Weill Cornell Medicine, New York, NY
*Purpose: A major obstacle after kidney transplantation (KT) is chronic allograft dysfunction characterized by interstitial fibrosis and tubular atrophy (IFTA). Despite extensive research, the cellular…
2022 American Transplant Congress
Modification of Gut Microbiota Accelerates Kidney Repair After Experimental Ischemia Reperfusion Injury
S. Gharaie, K. Lee, S. Noel, L. Arend, H. Rabb
Johns Hopkins Medicine, Baltimore, MD
*Purpose: Kidney ischemia reperfusion injury (IRI) leads to changes in gut microbiome, and pre-IR microbiome changes can modify course of experimental tissue injury. There is…
2022 American Transplant Congress
Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration
Y. Shim¹, R. Fan², N. Dvorina², K. McCrae¹, B. William²
¹Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, ²Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
2022 American Transplant Congress
Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells
J. Zhang¹, M. Ni¹, H. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², J. Jin³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ³Guilin Medical University, Guilin, China
*Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…