Am J Transplant, Volume 22, Suppl 3 Archives - Page 143 of 190 - ATC Abstracts

2022 American Transplant Congress
Nocardia Infection and Associated Outcomes in Patients with Solid Organ Transplant
R. Munshi¹, J. Pellegrini Jr.¹, M. Lannom¹, N. Nehru², W. Olsthoorn², F. Anjum³
¹Internal Medicine, Nassau University Medical Center, West Hempstead, NY, ²American University of the Caribbean, Cupecoy, Saint Martin, ³Pulmonary and Critical Care, University of Pennsylvania, Philadelphia, PA
*Purpose: Solid organ transplant (SOT) recipients face various challenges including increased risk of infections. Nocardia is a known pathogen for infecting immunosuppressed individuals, however, there…
2022 American Transplant Congress
Delivery of Plasmin During Machine Perfusion or Cold Storage Flush Improves Early Transplant Outcomes in aRat Dcd Liver Transplant Model
N. Abraham¹, M. Zhang¹, P. Cray², R. Neill¹, G. Cywinska¹, J. Migaly¹, R. Kahan¹, A. Pontula¹, J. Penaflor¹, Q. Gao¹, K. P. Samy¹, J. J. Pollara², V. Novokhatny³, M. G. Hartwig¹, A. S. Barbas¹
¹Duke Division of Abdominal Transplant Surgery, Duke Ex-Vivo Organ Lab (DEVOL), Durham, NC, ²Duke Division of Surgical Sciences, Pollara lab, Durham, NC, ³Bioscience Industrial Group, Grifols R&D, Durham, NC
*Purpose: Ischemic injury of the peribiliary glands and vascular plexus has been described in DCD livers and correlates with the development of cholangiopathy. Investigators have…
2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²
¹Surgery - Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
2022 American Transplant Congress
Longitudinal Analysis of the Gut Microbiota Structure and Function After Renal Transplantation
A. Vaitkute¹, F. Yuen Chang¹, A. Greco², S. Chong¹, H. Mahdi³, M. Bajaj-Elliott², A. Pesenacker¹, R. Motallebzadeh¹
¹Institute of Immunity and Transplantation, UCL, London, United Kingdom, ²Institute of Child Health, UCL, London, United Kingdom, ³Department of Renal Medicine, UCL, London, United Kingdom
*Purpose: Despite marked improvements in outcomes after renal transplantation, graft loss from alloimmune pathology and adverse side effects including urinary tract infections and diarrhoea remain…
2022 American Transplant Congress
CCR2 Antagonism Blocks Microbiota Pro-Inflammatory Effects on Lymph Node Architecture
S. J. Gavzy¹, R. Lakhan², J. Iyyathurai², V. Saxena², Z. L. Lee², B. Ma², E. Mongodin², J. S. Bromberg²
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland, Baltimore, MD
*Purpose: Fecal microbiota transfer (FMT) of Desulfovibrio desulfuricans (Desulfo) triggers a pro-inflammatory immune state, causing decreased laminin α4:α5 ratios in the lymph node (LN), increased…
2022 American Transplant Congress
Utility of Cytomegalovirus T-Cell Immunity Panel to Predict CMV Infections in Lung Transplant Recipients
R. W. Lincoln¹, B. J. Pierce¹, C. Pham¹, S. W. Yau², A. Goodarzi², J. G. Youssef², H. J. Huang²
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²Pulmonology, Houston Methodist Hospital, Houston, TX
*Purpose: Given the limited data of cytomegalovirus T-cell immunity panels (CMV TCIP) in lung transplant recipients (LTR), we sought to describe our center’s experience with…
2022 American Transplant Congress
Plasmapheresis and Rituximab for Prevention of Focal Segmental Glomerulosclerosis Recurrence Post-Kidney Transplantation
A. N. Yun¹, A. W. Rogers¹, J. C. Krisl¹, A. Kagan², H. E. Adrogue², A. J. Khan², P. Khairallah², S. G. Yi³, M. J. Hobeika³, R. R. McMillan³, H. Podder³, A. O. Gaber³, R. J. Knight³
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²Nephrology, Houston Methodist Hospital, Houston, TX, ³Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Primary focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation (KT) in 30-50% of recipients with a median time of 1.5 months post-KT. Recurrence is…
2022 American Transplant Congress
Development of a Patient-Reported Outcome Measure of Neurological Side Effects from Immunosuppression in Kidney Transplant Recipients
C. Hurt¹, G. J. Greene¹, J. Friedewald², D. P. Ladner², A. Waterman³, D. Cella¹, D. Peipert¹
¹Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Surgery and J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: Though kidney transplant is the optimal treatment for most individuals with end stage kidney disease, recipients experience significant side effects associated with their required…
2022 American Transplant Congress
Pro- and Anti-Tolerogenic Microbiota Induce Distinct Gut Microbiome Metabolic Pathways and Loco-Regional Immune Responses
S. J. Gavzy¹, R. Lakhan², J. Iyyathurai², V. Saxena², Z. L. Lee², B. Ma², E. Mongodin², J. S. Bromberg²
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland, Baltimore, MD
*Purpose: Colitis-associated Desulfovibrio desulfuricans (Desulfo) induces pro-inflammatory cytokine responses in dendritic cell and macrophage cell lines as well as primary cells. In contrast, Bifidobacterium pseudolongum…
2022 American Transplant Congress
Role of CD8⁺T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft
J. Ge¹, E. Szuter¹, T. Yokose¹, I. Rosales², A. Cuenca³, P. Russell¹, J. Madsen¹, R. Colvin², A. Alessandrini¹
¹Center of Transplant Science, Massachusetts General Hospital, Boston, MA, ²Department of Pathology, Massachusetts General Hospital, Boston, MA, ³Department of Surgery, Boston Children's Hospital, Boston, MA
*Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…