ATC Abstracts

American Transplant Congress abstracts

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  • 2022 American Transplant Congress

    Deep-Learning Based Pathological Assessment of Frozen Procurement Kidney Biopsies

    Z. Yi1, C. Xi1, M. Menon2, P. Cravedi1, B. Murphy1, S. Ward1, F. Salem1, W. Zhang1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Yale University School of Medicine, New York, NY

    *Purpose: Organ shortage in kidney transplantation is a major issue for ESKD individuals on the waiting list. Sclerotic glomeruli or interstitial fibrosis on procurement donor…
  • 2022 American Transplant Congress

    Comprehensive Profiling of Monocytes During Cellular (TCMR) or Mixed Antibody-Mediated Rejection (ABMR) After Kidney Transplantation

    C. Macedo1, E. Bailly1, K. Louis2, X. Gu1, M. Lucas1, A. Zeevi1, P. Randhawa1, A. Bansal3, D. Metes1

    1Starzl Transplantation Institute, Pittsburgh, PA, 2INSERM UMR-S976, Paris, France, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose: Monocytes play an important role in the immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate…
  • 2022 American Transplant Congress

    Meld Score <31 Predicts Spontaneous Recovery in Patients Listed for Liver Transplantation for Alcohol-Associated Hepatitis: A UNOS Database Study

    Y. Bekki, G. Im, T. Schiano, S. Florman

    Icahn School of Medicine at Mount Sinai, RMTI, New York, NY

    *Purpose: Alcohol-associated hepatitis (AH) is the fastest growing indication for liver transplantation (LT) in the U.S. While spontaneous recovery (SR) can occur in patients with…
  • 2022 American Transplant Congress

    Controlling Instability at Reperfusion: Another Benefit of Normothermic Machine Perfusion Using OCS Liver

    C. S. Hwang1, C. Shi2, M. Patel1, J. Shah1, L. DeGregorio1, S. Hanish1, Y. Kadakia3, U. Chaudhary3, E. Okoro2, S. Cheruku2, P. Lahsaei2, P. Vagefi1, M. MacConmara4

    1Surgery, University of Texas Southwestern Medical Center, Dallas, TX, 2Anesthesia, University of Texas Southwestern Medical Center, Dallas, TX, 3University of Texas Southwestern Medical Center, Dallas, TX, 4TransMedics, Andover, MA

    *Purpose: Organ Care System (OCS) Liver is a portable ex-vivo normothermic liver perfusion device recently shown to provide superior donor organ preservation. The impact of…
  • 2022 American Transplant Congress

    Desensitization Using Costimulatory Blockade and Bortezomib to Prevent DSA Formation and Rejection in Reconstructive Transplantation

    B. Oh, F. Messner, Y. Guo, G. Brandacher

    Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Sensitization in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection constitute some of the greatest risk factors for allograft rejection and long-term graft…
  • 2022 American Transplant Congress

    RNA Sequencing Profiling of Pretransplant Blood Identified Variant Allele Specific Expression of Leukocyte Immunoglobulin-Like Receptors (LILRs) Genes Associated with Graft Loss in Kidney Transplant Recipients

    Z. Sun1, Z. Yi1, Z. Zhang1, P. Cravedi1, M. Menon2, B. Murphy1, S. Chen3, W. Zhang1

    1Icahn School of Medicine at Mount Sinai, New York City, NY, 2Yale University School of Medicine, New Heaven, CT, 3Methodist Hospital, Houston, TX

    *Purpose: The RNA sequencing has the possibility of detecting overall gene expression as well as allele-specific expression. Here, we reported a study of genome-wide allele…
  • 2022 American Transplant Congress

    Aquaporin 4 is a Mediator of Essential Dendritic Cell Functions

    M. Nicosia1, A. M. Beavers1, Y. Yamamoto1, T. Thompson2, T. Zindrick2, A. Valujskikh1

    1Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 2Aeromics, Cleveland, OH

    *Purpose: Aquaporins are a family of transmembrane water channels implicated in a broad range of physiological functions. We previously reported that Aquaporin 4 (AQP4) is…
  • 2022 American Transplant Congress

    A Pathway for Establishing Etiology of Kidney Failure: An Academic Transplant Center’s Experience with a Broad Kidney Gene Panel

    R. Sodhi1, K. Brossart2, A. Desai1, D. J. Arwindekar1, H. Tabriziani2, S. Akkina1

    1Loyola University Medical Center, Maywood, IL, 2Natera, Inc., Austin, TX

    *Purpose: Assessing genetic causes of kidney failure can inform pre-transplant decision making and may improve post-transplant outcomes. Here we describe an academic transplant center’s experience…
  • 2022 American Transplant Congress

    Fibrinolysis Shutdown Subtype of Early Allograft Dysfunction Represents the Predominant Cohort of Patients with Graft Failure Following Liver Transplantation

    H. B. Moore1, T. L. Nydam2, M. Adams3, T. Ferrell1, I. Rodriguez4, D. Yoeli1, R. Choudhury1, J. Pomposelli1, E. A. Pomfret1

    1University of Colorado, Aurora, CO, 2Univeristy of Colorado, Aurora, CO, 3Childrens Hospital Colorado, Aurora, CO, 4University of Colorado Anschutz Medical Campus, Aurora, CO

    *Purpose: Early allograft dysfunction (EAD) is associated with an increased rate of graft failure in liver transplantation (LT), but a mechanism remains unclear. Recent experience…
  • 2022 American Transplant Congress

    A Machine Learning Model for Predicting Antibody Response to 2-Dose Sars-cov-2 MRNA Vaccine Series in Transplant Recipients

    J. L. Alejo1, J. Mitchell1, T. Chiang1, A. Abedon1, W. Werbel1, R. Avery1, A. Tobian1, A. Massie1, J. Garonzik-Wang2, D. Segev1, S. Bae1

    1JHU, Baltimore, MD, 2U of Wisconsin, Madison, WI

    *Purpose: Understanding risk factors for impaired vaccine responses can guide strategies for testing, additional dose recommendations, and vaccine schedules to provide improved protection in solid…
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