Am J Transplant, Volume 22, Suppl 3 Archives - Page 140 of 190 - ATC Abstracts

2022 American Transplant Congress
TNFRSF13B Genotype Determines the Properties of Donor-Specific B Cells
M. Cascalho¹, M. Garcia de Mattos Barbosa¹, T. Pasieka¹, E. Farkash², R. Sung³, M. Doshi⁴, J. Platt⁴
¹Surgery, University of Michigan, Ann Arbor, MI, ²Pathology, University of Michigan, Ann Arbor, MI, ³University of Michigan Health System, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI
*Purpose: The TNFRSF13B gene is among the 5% most polymorphic genes in humans. The phenotypes of the most frequent TNFRSF13B variants in humans and mice…
2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
X. Lai¹, J. Wang¹, S. Han¹, C. Chunlei¹, L. VanOsdol¹, L. Gallon², J. Leventhal², M. Kandpal¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
2022 American Transplant Congress
Association of Chest CT Score During Acute COVID-19 Illness with Subsequent Lung Function Loss Among Lung Transplant Patients
Q. M. Halverson, K. Batra, L. D. Mahan, M. Mohanka, A. C. Lawrence, J. Joerns, S. Bollineni, V. Kaza, I. L. Timofte, C. D. Kershaw, L. C. Terada, F. Torres, A. Banga
University of Texas Southwestern, Dallas, TX
*Purpose: Limited data exists on CT chest abnormalities during acute Coronavirus disease 2019 (COVID-19) infection and associated post-illness loss of lung function among lung transplant…
2022 American Transplant Congress
Single Cell And Spatial Transcriptomics Of Blood And Biopsies Reveals Enhanced Alloantigen Presenting Function And T-follicular Helper Cell (tfh) Expansion Early After Pediatric Liver Transplantation
R. Sindhi¹, C. Ashokkumar¹, M. Ningappa¹, D. Rajasundaram¹, B. W. Higgs¹, Q. Xu², A. Zeevi², M. Reyes-Mugica¹
¹Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We have previously reported enhanced B-cell presentation of donor antigen during early T-cell mediated liver transplant (LT) rejection.*Methods: To characterize B-cell related immunological mechanisms…
2022 American Transplant Congress
Direct Central Ambulatory Venoarterial Extracorporeal Membrane Oxygenation and Double Lung Transplantation without Graft Reduction with Extreme Mediastinal Shift
A. Gorton¹, S. Keshavamurthy²
¹Cardiothoracic Surgery, University of Kentucky, Lexington, KY, ²University of Kentucky, Lexington, KY
*Purpose: Double Lung transplantation in the presence of extreme mediastinal shift can be technically challenging due to donor sizing and recipient factors.*Methods: We present the…
2022 American Transplant Congress
The Ontario Anatomic Kidney Score (OAKS) : Quantitative Macroscopic Assessment versus Histological Grading in Pre-transplant Evaluation of Donor Kidneys
J. Mello Offerni¹, D. Matty², H. Abed³, P. Roshanov⁴, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Undergraduate Medical Education, Western University, Schulich School of Medicine & Dentistry, London, ON, Canada, ³Division of Urology, Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, ⁴Division of Nephrology, Department of Internal Medicine, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
*Purpose: Quantitative gross assessment of a kidney has not been used to influence the evaluation to utilize a kidney for transplantation. The Ontario Anatomic Kidney…
2022 American Transplant Congress
Validation of the iBox Surrogate End Point in CNI Free, Belatacept Treated Patients (BENEFIT & BENEFIT-EXT)
G. Divard¹, O. Aubert¹, M. Raynaud¹, F. Vincenti², L. Rostaing³, A. Durbach⁴, C. Legendre¹, R. Vadanici⁵, A. Loupy¹, -. BENEFIT & BENEFIT-EXT Investigators⁶
¹Paris Transplant Group, INSERM, Paris, France, ²UCSF, San Francisco, CA, ³Grenoble, Grenoble, France, ⁴APHP, Paris, France, ⁵BMS, Rueil Malmaison, France, ⁶BMS, New York, NY
*Purpose: The iBox is a prognostication system for long-term kidney allograft survival, developed with mostly patients under a CNI based immunosuppression. Patients treated with a…
2022 American Transplant Congress
DCD vs DBD Pancreas Transplant Outcome – A Comprehensive Registry Analysis
A. C. Gruessner¹, S. J. Saggi², R. Gruessner¹
¹SUNY Downstate Medical Center, Brooklyn, NY, ²Medicine, SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Pancreas transplantation offers long-term independence from insulin injections for patients with labile diabetes mellitus. After a decade of decline (2004-2015), the number of pancreas…
2022 American Transplant Congress
Final Flow and Resistance with Cold Pulsatile Perfusion Preservation Are Independent Risk Factors for Dialysis in the First Week Post-Transplant, Analysis of SRTR Data
D. S. Keith, E. Lessmann
Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine if final flow or resistance on cold pulsatile perfusion preservation (CPPP) have independent predictive value for dialysis in the first week post-transplant.*Methods:…
2022 American Transplant Congress
VCA Waiting List and Transplant Trends and Challenges in the US
J. Wainright¹, W. Cherikh¹, S. Booker¹, D. Klassen²
¹Research, UNOS, Richmond, VA, ²Office of the CMO, UNOS, Richmond, VA
*Purpose: VCA transplantation has grown and changed, encountering challenges such as scarce funding sources and the COVID-19 pandemic.*Methods: The OPTN cohort includes 105 candidates listed…