Am J Transplant, Volume 22, Suppl 3 Archives - Page 138 of 190 - ATC Abstracts

2022 American Transplant Congress
Delivery of Plasmin During Machine Perfusion or Cold Storage Flush Improves Early Transplant Outcomes in aRat Dcd Liver Transplant Model
N. Abraham¹, M. Zhang¹, P. Cray², R. Neill¹, G. Cywinska¹, J. Migaly¹, R. Kahan¹, A. Pontula¹, J. Penaflor¹, Q. Gao¹, K. P. Samy¹, J. J. Pollara², V. Novokhatny³, M. G. Hartwig¹, A. S. Barbas¹
¹Duke Division of Abdominal Transplant Surgery, Duke Ex-Vivo Organ Lab (DEVOL), Durham, NC, ²Duke Division of Surgical Sciences, Pollara lab, Durham, NC, ³Bioscience Industrial Group, Grifols R&D, Durham, NC
*Purpose: Ischemic injury of the peribiliary glands and vascular plexus has been described in DCD livers and correlates with the development of cholangiopathy. Investigators have…
2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²
¹Surgery - Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
2022 American Transplant Congress
Longitudinal Analysis of the Gut Microbiota Structure and Function After Renal Transplantation
A. Vaitkute¹, F. Yuen Chang¹, A. Greco², S. Chong¹, H. Mahdi³, M. Bajaj-Elliott², A. Pesenacker¹, R. Motallebzadeh¹
¹Institute of Immunity and Transplantation, UCL, London, United Kingdom, ²Institute of Child Health, UCL, London, United Kingdom, ³Department of Renal Medicine, UCL, London, United Kingdom
*Purpose: Despite marked improvements in outcomes after renal transplantation, graft loss from alloimmune pathology and adverse side effects including urinary tract infections and diarrhoea remain…
2022 American Transplant Congress
Specificity and Avidity of Donor MHC-Specific B Cells in Naive, Rejecting and Tolerant Mice
I. Sayin¹, S. Khiew², D. Yin¹, P. Sage³, C. B. Cavazzoni³, R. King⁴, A. Chong¹
¹Department of Surgery, University of Chicago, Chicago, IL, ²Merck, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Department of Microbiology, University of Alabama, Birmingham, AL
*Purpose: Antibody-mediated rejection is recognized as an important mediator of graft loss in the clinic, and the induction of donor-specific B cell tolerance may contribute…
2022 American Transplant Congress
Impact of Arterial Reconstruction Technique on Hepatic Arterial Thrombosis in a Decade of Pediatric Liver Transplantation
A. M. Delman¹, Z. Farooqi¹, E. Schepers¹, A. Bondoc², G. Tiao², B. Mullapudi²
¹Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, ²Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Hepatic artery thrombosis (HAT) is a morbid and potentially fatal complication following pediatric liver transplantation (PLT). Previous registry studies have identified preoperative characteristics associated…
2022 American Transplant Congress
Gene Expression Profiles of Peritubular Capillarits in Chronic Antibody-Mediated Rejection
M. Eder¹, M. Röbl¹, H. Omic¹, B. Adam², D. Cejka³, N. Kozakowski⁴, D. D´Andrea⁵, M. Mengel², Ž. Kikić⁵
¹Internal Medicine III, Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada, ³Department of Medicine III, Nephrology, Hypertension, Transplantation and Rheumatology, Ordensklinikum Linz – Elisabethinen, Linz, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Department of Urology, Medical University of Vienna, Vienna, Austria
*Purpose: Antibody-mediated rejection (ABMR) is one of the most significant contributors to late graft loss. Hallmark characteristics include peritubular capillaritis (ptc) and glomerulitis (g). Diffuse…
2022 American Transplant Congress
Post Transplant Virologic Outcomes in DCD Kidney Transplant Recipients Treated with Thymoglobulin Induction Immunosuppression and Maintenance Belatacept vs Calcineurin Inhibitor Therapy
T. Engebretsen¹, M. Kueht¹, A. Lea², M. Mujtaba³
¹Abdominal Transplant Surgery, University of Texas Medical Branch, Galveston, TX, ²Infectious Disease, University of Texas Medical Branch, Galveston, TX, ³Nephrology, University of Texas Medical Branch, Galveston, TX
*Purpose: Belatacept is an inhibitor of the T-Cell costimulatory pathway that can be used in recipients of Donation after Circulatory Death (DCD) where the intended…
2022 American Transplant Congress
Flow Cytometric Pattern of γδ Tcr Expression Identifies Outcomes in Kidney Transplantation
S. Sur, S. Pineda, M. Sirota, M. Sarwal
UCSF, San Francisco, CA
*Purpose: The main challenge with kidney transplantation is the possibility of rejection, classified into two types, antibody-mediated rejection (ABMR) and T cell-mediated rejection (TCMR). The…
2022 American Transplant Congress
P2X7R Inhibition Impairs In Vitro Training of Macrophages
H. H. Lancia¹, R. Sanchez², A. G. Lellouch¹, C. L. Cetrulo¹, J. Ochando³, G. Benichou⁴
¹Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…
2022 American Transplant Congress
Increased Plasminogen Activator Inhibitor-1 is Associated with Less Severe Clinical Bleeding After Reperfusion During Liver Transplantation
H. J. Braun, N. Ascher, G. Roll, J. Roberts, C. Niemann, M. Bokoch
University of California, San Francisco, San Francisco, CA
*Purpose: Severe bleeding following reperfusion in liver transplantation (LT) is often discrepant with available objective laboratory and thromboelastography data. This bleeding may be due to…