Am J Transplant, Volume 22, Suppl 3 Archives - Page 137 of 190 - ATC Abstracts

2022 American Transplant Congress
Cardiovascular Assessment After Kidney Transplantation in Children and Adolescents
J. Liu, L. Zhang, X. Li, L. Zhu, Y. Lin, X. He, L. Liu, J. Li, C. Wang, S. Li
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: End-stage renal disease is often accompanied by cardiovascular events, and cardiovascular events still exist after kidney transplantation. Cardiovascular disease is the main cause of…
2022 American Transplant Congress
Lung Transplant Recipients with Sars-cov2 Infection and Bnt162b2 Vaccination Induce Circulating Exosomes with Spike Protein S2 Capable of Inducing Immune Responses to Sars0-cov2 in Mice
S. Bansal¹, B. Tiffany¹, T. Fleming¹, S. Perincheri², M. Smith¹, R. Bremner¹, T. Mohanakumar¹
¹St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²Yale School of Medicine, New Haven, CT
*Purpose: Exosomes are small vesicles which are released by cells into body fluids. We have demonstrated the presence of circulating exosomes with viral antigens in…
2022 American Transplant Congress
Clinical Outcomes of Solid Organ Transplant (SOT) Patients with Epstein-Barr Virus-Driven (EBV⁺) Post-Transplant Lymphoproliferative Disease (PTLD) Who Fail Rituximab Plus Chemotherapy: A Multinational, Retrospective Chart Review Study
V. Dharnidharka¹, D. Thirumalai², U. Jaeger³, W. Zhao², D. Dierickx⁴, P. Xun², P. Minga⁵, A. Sawas⁶, N. Sadetsky⁷, P. Chauvet⁸, E. Sundaram⁹, A. Barlev⁷, H. Zimmermann¹⁰, R. U. Trappe¹⁰
¹Washington University School of Medicine/St Louis Children’s Hospital, St Louis, MO, ²Atara Biotherapeutics, Thousand Oaks, CA, ³Medical University of Vienna, Vienna, Austria, ⁴Universitair Ziekenhuis Leuven, Leuven, Belgium, ⁵Niguarda Ca’ Granda Hospital, Milan, Italy, ⁶Herbert Irving Comprehensive Cancer Center, Department of Medicine, CUMC, New York, NY, ⁷Atara Biotherapeutics, South San Francisco, CA, ⁸Service des Maladies du Sang, CHU Lille, Lille, France, ⁹Nashville Biosciences, Nashville, TN, ¹⁰DIAKO Bremen, Bremen, Germany
*Purpose: EBV+ PTLD patients (pts) following SOT who fail rituximab + chemotherapy (CT) have poor outcomes with limited treatment options. Published data on clinical outcomes…
2022 American Transplant Congress
Cognitive Bias in Transplant Surgery: A Qualitative Study of Transplant Clinicians in the United States
K. Ladin¹, J. Perry², C. Eiduson³
¹REACH Lab, Tufts University, Medford, MA, ²Harvard University, Cambridge, MA, ³University of Rochester School of Medicine & Dentistry, Rochester, NY
*Purpose: Clinicians’ judgments about patients’ social support often affect whether patients are listed for transplantation. Decision-making is thought to be based on two systems of…
2022 American Transplant Congress
Bcl6 Regulates NFκB-Controlled Endothelial Inflammation and Apoptosis
A. Franco Acevedo, N. Valenzuela
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Endothelial cells (EC) centrally regulate leukocyte access to peripheral tissue and immune cell activation, and exhibit remarkable tissue-specific diversity. However, the molecular mechanisms underlying…
2022 American Transplant Congress
Evaluation of Diabetes-Free Life Expectancy Among Living Kidney Donors and Non-Donors with Obesity: A Longitudinal Cohort Study
C. Killian¹, R. Reed¹, M. McLeod¹, P. MacLennan¹, V. Kumar¹, S. Brooks¹, A. Maynor¹, L. Stanford¹, G. Baker¹, C. Schinstock², J. Silkensen³, G. Roll⁴, D. Segev⁵, B. Orandi¹, C. Lewis¹, J. Locke¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Mayo Clinic, Rochester, MN, ³Hennepin County Medical Center, Minneapolis, MN, ⁴UCSF Medical Center, San Francisco, CA, ⁵Johns Hopkins University, Baltimore, MD
*Purpose: The growing end stage kidney disease burden paired with substantial rates of obesity in the United States (US) has prompted increased approval of obese…
2022 American Transplant Congress
Single Cell RNA Sequencing Identifies Primarily Terminal Effector and Exhausted CD8⁺T Cells in Chronically Rejected Human Kidney Allografts
S. G. Yi¹, D. Zou¹, Y. Dai², Z. Zhao², W. Chen¹, A. Gaber¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX
*Purpose: Chronic renal allograft rejection often leads to irreversible damage, despite intensification of immunosuppression (ISN). T cell phenotypes in this clinical setting are not well…
2022 American Transplant Congress
Ex Vivo Liver Resection and Autotransplantation – Should It Be Used More Frequently?
J. Weiner¹, A. Griesemer¹, A. Hemming², D. Levi³, T. Beduschi⁴, R. Matsumoto¹, A. Mathur¹, J. Emond¹, T. Kato¹
¹Columbia University Irving Medical Center, New York, NY, ²University of Iowa, Iowa City, IA, ³Atrium Health, Charlotte, NC, ⁴University of Florida, Gainesville, FL
*Purpose: Ex vivo liver resection expands the limits of resectability for advanced liver tumors but remains underutilized due to concerns about technical complexity and vascular…
2022 American Transplant Congress
Combined Heart-Liver Transplantation for Failing Fontan Physiology: A Large Single Center Comparative Analysis
C. J. Rosenthal¹, D. Noguchi¹, J. A. Aboulhosn², G. S. Van Arsdell³, A. Nsair⁴, M. Ha¹, L. Reardon², G. Lluri⁴, J. P. Lin⁴, S. Saab¹, A. Baird¹, R. S. Venick¹, D. G. Farmer¹, F. M. Kaldas¹
¹Liver and Pancreas Transplant Center, UCLA, Los Angeles, CA, ²Ahmanson/UCLA Adult Congenital Heart Disease Center, UCLA, Los Angeles, CA, ³Cardiac Surgery, UCLA, Los Angeles, CA, ⁴Cardiology, UCLA, Los Angeles, CA
*Purpose: The rate of combined heart-liver transplantation (HLT) has tripled in the last decade, and continues to rise along with the number of patients with…
2022 American Transplant Congress
Better Antibody Response After a Dose of Ad.26.cov2.s vs MRNA Vaccines in Seronegative Transplant Recipients After 2-Dose MRNA Vaccination
J. L. Alejo¹, T. Chiang¹, J. Mitchell¹, A. Abedon¹, L. Thomas¹, A. Chang¹, S. Bae¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: To compare antibody response to a third dose (D3) of SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) with negative or low-positive antibody levels…