Am J Transplant, Volume 22, Suppl 3 Archives - Page 131 of 190 - ATC Abstracts

2022 American Transplant Congress
A Machine Learning Approach to Estimating Anticipated Waiting Time and Survival Benefit in Older Kidney Transplant Candidates
D. M. Vock¹, E. S. Helgeson², A. J. Matas²
¹University of Minnesota, Minneapolis, MN, ²U MN, Mpls, MN
*Purpose: Older kidney transplant (ktx) recipients face worse post-transplant survival due to increasing age and more comorbidities. Simultaneously, older ktx candidates are more likely to…
2022 American Transplant Congress
Decision-Making Among HCV-Negative Transplant Candidates Offered Organs from Donors with HCV Infection
E. Schnellinger¹, E. Saine¹, M. Liu¹, J. Diamond¹, M. Crespo¹, S. Prenner¹, V. Potluri¹, C. Bermudez¹, H. Mentch¹, M. Moore², B. Besharatian¹, D. Goldberg³, F. Barg¹, P. Reese¹
¹University of Pennsylvania, Philadelphia, PA, ²University of London, London, United Kingdom, ³University of Miami, Miami, FL
*Purpose: Historically, many organs from deceased donors with hepatitis C virus (HCV) infection were discarded due to stigma and challenges in treating HCV after transplant.…
2022 American Transplant Congress
TEMRA CD8 T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2x4 Receptor-Dependent Proinflammatory and Migratory Responses
G. Tilly¹, T. Doan-Ngoc¹, O. Bonizec¹, C. Masset², R. Danger³, P. Guérif¹, S. Bruneau¹, J. Harb¹, M. Giral¹, C. Pecqueur⁴, S. Brouard¹, N. Degauque¹
¹Nantes Université, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France, ²University Hospital of Nantes, Nantes, France, ³CRTI- INSERM UMR 1064, Nantes, France, ⁴Nantes Université, Univ Angers, INSERM, CNRS, CRCINA, F-44000 Nantes, Nantes, France
*Purpose: Whereas the role of effector memory and TEMRA CD8 in allotransplantation has been clearly evidenced and particularly the direct correlation between intragraft infiltrating CD8…
2022 American Transplant Congress
Why Females Have Weaker Tregs Than Males: Inhibitory Effects of Estrogen Receptor Signaling on Foxp3+ Treg Cell Suppressive Function
L. M. Christensen¹, T. Akimova¹, G. Ge², R. Han¹, L. Wang³, C. O'Brien², M. Levine², W. W. Hancock³
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Estrogen signaling is thought to play a role in nearly every cell type, but the biological significance of estrogen signaling via estrogen receptors in…
2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
2022 American Transplant Congress
Allogenic Cardiac Progenitor Cells Transplantation with Immune Suppressant Cyclosporine a Recovers Myocardial Infarction in Rodent Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal
Pediatrics, Lurie Childrens Hospital, Chicago, IL
*Purpose: Cardiac progenitor cells (CPCs) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo immune…
2022 American Transplant Congress
Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal
Lurie Childrens Hospital, Chicago, IL
*Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…
2022 American Transplant Congress
Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1; Hcd39) Did Not Afford Significant Protection on Porcine Endothelial Cells
R. Matheson¹, B. Gonzalez Nolasco¹, K. Deng¹, R. Garofalo¹, N. Serifis¹, T. M. Coe¹, C. Rhatigan¹, D. Gil¹, D. Cloonan¹, K. Lee¹, K. Hall², M. Youd², J. F. Markmann¹, S. C. Robson³
¹Transplantation surgery research, Massachusetts General Hospital, Boston, MA, ²eGenesis Bio, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: The thromboregulatory and anti-inflammatory potential of human CD39 (hCD39) makes it a gene of interest in xenotransplantation. In porcine endothelium, CD39 activity is generally…
2022 American Transplant Congress
Prospective Evaluation of Donor-Derived Cell-Free DNA (dd-cfDNA) in Monitoring Response to Anti-Rejection Treatment in Kidney Transplant Recipients with Indication Biopsy
L. Benning¹, A. Fink², F. Kälble¹, C. Speer¹, C. Nusshag¹, M. Zeier¹, C. Süsal³, C. Morath¹, T. Tran²
¹Department of Nephrology, University Hospital Heidelberg, Heidelberg, Germany, ²Transplantation Immunology, Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany, ³Transplant Immunology Research Center of Excellence, Koç University Hospital, Istanbul, Turkey
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a marker of allograft injury in kidney transplant recipients (KTR). Little is known about the possible use of dd-cfDNA…
2022 American Transplant Congress
Letermovir for Prophylaxis of Cytomegalovirus After Solid Organ Transplantation: A Single-Center, Observational Study
T. N. Bullard¹, C. A. Moore², J. Dasigi², L. M. Sacha², C. A. Iasella³, K. A. Shimko², E. K. McCreary⁴, F. P. Silveira⁴
¹Massachusetts General Hospital, Boston, MA, ²UPMC, Pittsburgh, PA, ³Univ of Pittsburgh, Pittsburgh, PA, ⁴Univ of Pittsburgh and UPMC, Pittsburgh, PA
*Purpose: Cytomegalovirus (CMV) infections cause significant complications post-transplant; however, prophylactic medications are often limited by toxicities. Letermovir is a novel terminase inhibitor specific to CMV…