Am J Transplant, Volume 22, Suppl 3 Archives - Page 131 of 190 - ATC Abstracts

2022 American Transplant Congress
Use of Organ-Specific Chimeric Antigen Receptor Promotes Liver Recruitment of Regulatory T Cells
E. Landmann¹, P. Ruiz¹, A. Kurt¹, E. Kodela¹, M. Martinez-Llordella², A. Sanchez-Fueyo¹
¹King's College London, London, United Kingdom, ²Quell Therapeutics, London, United Kingdom
*Purpose: Owing to their potent immune-modulatory properties, regulatory T cells (Tregs) have been explored as novel cell therapy to induce allograft tolerance, with first clinical…
2022 American Transplant Congress
Modern Medicine Needs Modern Technology Tools
Z. S. Soltani,, S. Soltani
Ochsner Foundation Hospital, New Orleans, LA
*Purpose: Dd-cfDNA has been used as a non-invasive biomarker for allograft injury and has been shown to detect subclinical rejection with higher predictive power compare…
2022 American Transplant Congress
Older Donor Age is Associated with Worse Living Donor Liver Transplantation Outcomes in a National US Cohort
M. Kanneganti¹, K. M. Olthoff², T. Bittermann³
¹Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Department of Surgery, University of Pennsylvania, Philadelphia, PA, ³Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA
*Purpose: To evaluate the impact of increasing living donor (LD) age on living donor liver transplantation (LDLT) outcomes in the U.S.*Methods: A retrospective cohort of…
2022 American Transplant Congress
A Qualitative Comparison of Declined Hispanic and Non-Hispanic Living Liver Donor Candidates at a High-Volume Urban Transplant Center
D. Toy¹, B. Horwich¹, A. Mulgaonkar¹, A. Padilla², J. L. Dodge³, N. Kaur⁴, H. Han³
¹Department of Medicine, University of Southern California, Los Angeles, CA, ²USC Transplant Institute, University of Southern California, Los Angeles, CA, ³Division of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, CA, ⁴Department of Surgery, University of Southern California, Los Angeles, CA
*Purpose: To compare Hispanic and non-Hispanic living liver donor candidates who were declined by a multidisciplinary selection committee at a large urban transplant center.*Methods: The…
2022 American Transplant Congress
Is Remnant Liver Volume Ratio Less Than 30% Still Contraindication to Right Hepatectomy for Living Liver Donors?
J. Kim, D. Choi
Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Korea, Republic of
*Purpose: Recently, some centers reported that extended resection with remnant/total volume ratio(RTVR) less than 30% for living donor right hepatectomy(LDRH) but there is no consensus…
2022 American Transplant Congress
Prediction of Delayed Graft Function After Deceased Donor Kidney Transplantation Using Machine Learning and Sequential Donor Data
J. Sageshima¹, J. Yu¹, H. Lala Gul¹, F. De Leon¹, N. Goussous¹, N. Mineyev¹, P. Than¹, K. Jen², R. Perez¹
¹Surgery, University of California Davis Health, Sacramento, CA, ²Pathology, University of California Davis Health, Sacramento, CA
*Purpose: Delayed graft function (DGF) has been associated with adverse kidney transplant outcomes. Accurate prediction of DGF before surgery will help select organs and candidates…
2022 American Transplant Congress
Ficoll-Based Isolation Alters the Immunogenicity of Islets That Leads to Enhanced Rejection in Allogeneic Hosts
L. Zhang¹, A. Turan², M. Tarique¹, V. Ulker¹, E. Yolcu³, H. Shirwan³
¹Child Health, University of Missouri, Columbia, MO, ²Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, ³Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO
*Purpose: The purification of pancreatic islets has long relied on the time-consuming density gradient separation method. We herein report a filtration method as an efficient,…
2022 American Transplant Congress
The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors
M. Liao¹, Q. Fu², L. Wei³, H. Yang³, G. Zhao³, S. Deng³, J. F. Markmann²
¹School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ³University of Electronic Science and Technology of China, Chengdu, China
*Purpose: The study aims to develop RNA signature predictors using preemptive biopsy transcriptome data to predict future allograft rejection and reveal the predictors' time-dependent features.*Methods:…
2022 American Transplant Congress
Implications of Pre-Transplant (tx) COVID-19 on SOT or HCT: A Multicenter Study
G. Haidar¹, K. Hughes-Kramer², C. Alonso³, J. Hand⁴, E. Blodget⁵, V. Srinivasa⁵, S. Aslam⁶, H. Hassouna⁷, C. Lawson⁷, M. Malinis⁸, S. Anjan⁹, E. Lease¹⁰, M. Al-Obaidi¹¹, P. Vergidis¹², J. Husson¹³, D. van Duin¹⁴, R. Avery¹⁵, K. Downes¹⁶, M. R. Heldman¹⁰, J. Nelson¹⁷, S. Pouch¹⁸, S. Chuang¹⁹, C. Kao²⁰, M. Estabrook²¹, F. Alconchel²², S. Mazumber²³, P. Samanta², M. Wagener², N. Singh², F. Silveira²
¹UPitt, Pitt, PA, ²UPitt, Pittsburgh, PA, ³BIDMC, Boston, MA, ⁴Ochsner, New Orleans, LA, ⁵USC, Los Angeles, CA, ⁶UCSD, San Diego, CA, ⁷Spectrum Health, Grand Rapids, MI, ⁸Yale, New Haven, CT, ⁹UMiami, Miami, FL, ¹⁰UW, Seattle, WA, ¹¹U Arizona, Tucson, AZ, ¹²Mayo, Rochester, MN, ¹³UMMC, Baltimore, MD, ¹⁴UNC, Chapel Hill, NC, ¹⁵JHU, Baltimore, MD, ¹⁶CHOP, Philadelphia, PA, ¹⁷Stanford, Stanford, CA, ¹⁸Emory, Decatur, GA, ¹⁹U Rochester, Rochester, NY, ²⁰WashU, St Louis, MO, ²¹WashU, Saint Louis, MO, ²²Spain, Murcia, Spain, ²³U Tennessee, Memphis, TN
*Purpose: Describe outcomes of patients (pt) with pre-tx COVID-19.*Methods: Multicenter study of SOT/HCT candidates who had a positive (pos) SARS-CoV-2 PCR pre-tx.*Results: Pre-tx: Of 208…
2022 American Transplant Congress
Real World Experience Utilizing Donor Kidneys at Risk for Acute Kidney Injury with Belatacept Based Maintenance Immunosuppression
B. Sirandas, A. Chan, M. Eiting, T. Larson, C. Truax, L. Smith
University of Utah Health, Salt Lake City, UT
*Purpose: The demand for kidney transplant continues to rise, and limited supply has encouraged acceptance of marginal donor organs, such as those at risk for…