Am J Transplant, Volume 22, Suppl 3 Archives - Page 128 of 190 - ATC Abstracts

2022 American Transplant Congress
Production of Exosomal IL35 from Alloreactive Treg Cells: A Basis for Potent Immunotherapy and Tolerance in Human Kidney Transplantation
W. J. Burlingham¹, E. Jankowska-Gan², J. Fechner¹, C. Little¹, S. Tripathi³, B. Schreiber³, A. Chandraker³, D. Foley⁴
¹Surgery-Transplant Division, University of Wisconsin, Madison, WI, ²Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, ³Surgery-Transplant Division, Brigham & Women's Hospital, Boston, MA, ⁴University of Wisconsin, Madison, WI
*Purpose: Treg cells make a variety of immunosuppressive products—cytokines such as IL10, TGFβ, and IL35, and enzymes such as the CD39/CD73 pair that convert extracellular…
2022 American Transplant Congress
The Addition of Bortezomib to a Rituximab Based Antibody Mediated Rejection Treatment Protocol in Lung Transplant
M. Galle, P. Stracener, K. Warrior, J. Lyons
Loyola University Medical Center, Maywood, IL
*Purpose: To evaluate the impact of antibody mediated rejection (AMR) treatment with rituximab combined with bortezomib vs. rituximab alone on patient survival, graft survival, and…
2022 American Transplant Congress
Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression
K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann
Center for Transplantation Sciences, Boston, MA
*Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
2022 American Transplant Congress
Sleeve Gastrectomy Reduces Need for Liver Transplantation for NASH Patients
R. A. Choudhury¹, A. Rouhi², G. Hoeltzel³, Y. Bababekov¹, A. Suarez-Pierre⁴, A. Yule¹, N. Vigneshwar⁴, N. Williams⁵, K. Dumon², J. Pomposelli¹, H. B. Moore¹, E. Pomfret¹, T. Nydam¹
¹Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ³General Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, ⁴Cardiothoracic Surgery, University of Colorado Hospital, Aurora, CO, ⁵General Surgery, Hospital of the University of Pennsylvania, Aurora, CO
*Purpose: Non-Alcoholic Steatohepatitis (NASH) is one of the leading indications for liver transplantation (LT) in the United States. As with the current obesity epidemic, the…
2022 American Transplant Congress
Emphysematous Cystitis in a Lung Transplant Recipient with BK Viremia
D. Razia, J. Klein, H. Mohamed, A. Arjuna
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Emphysematous cystitis (EC) is a rare urinary tract infection from E. coli or K. pneumoniae in diabetics or immunocompromised individuals, resulting in sepsis and…
2022 American Transplant Congress
The Impact of Long-Term Exposure to Tacrolimus on Chronic Kidney Disease Following Lung Transplantation: A Retrospective Analysis from a Single Transplantation Center
D. Xiong, J. Zhang, J. Chen
Lung Transplantation Center, Department of Thoracic Surgery, Wuxi People’s Hospital Affiliated to Nanjing Medical Univer, Wuxi, China
*Purpose: Chronic kidney disease (CKD) is a progressive and irreversible complication in lung transplant patients who have received long-term treatment with tacrolimus. This study aimed…
2022 American Transplant Congress
Feasibility and Short-Term Outcomes of Kidney Transplantation Following Donation After Circulatory Death Using Thoracic Normothermic Regional Perfusion in the United States
L. Hickman, D. Shaffer, J. Hoffman, W. G. McMaster, A. S. Shah, R. Forbes
Surgery, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Organ donation after circulatory death (DCD) is an important component of kidney transplants in the US. Cardiac transplantation from DCD donors has previously been…
2022 American Transplant Congress
Real-Life Tacrolimus Levels Are Associated with Biopsy-Proven Acute Rejection After the First Year Post-Kidney Transplantation
S. Meziyerh, T. van Gelder, D. van der Helm, P. J. van der Boog, J. W. de Fijter, D. J. Moes, A. P. de Vries
LUMC, Leiden, Netherlands
*Purpose: Evidence to recommend specific target concentrations for immunosuppression beyond the first year of kidney transplantation (KT) is limited. We correlated real-life exposure data of…
2022 American Transplant Congress
Progression of Peripheral Vascular Disease After Kidney/Pancreas Transplantation
R. J. Knight, E. A. Graviss, D. T. Nguyen, Y. Ye, S. G. Yi, C. S. Bavare, A. R. Sadhu, H. Podder, M. Hobeika, R. McMillan, A. O. Gaber
Houston Methodist Hospital, Houston, TX
*Purpose: It is unclear whether kidney/pancreas (KP) transplantation will prevent the progression of peripheral vascular disease in patients with IDDM and ESRD. We sought to…
2022 American Transplant Congress
Prolonged Preservation by Hypothermic Machine Perfusion Facilitates Logistics in Liver Transplantation: A European Observational Cohort Study
I. M. Brüggenwirth¹, M. Mueller², V. A. Lantinga¹, S. Camagni³, R. De Carlis⁴, L. De Carlis⁵, M. Colledan⁶, D. Dondossola⁷, M. Drefs⁸, J. Eden², D. Ghinolfi⁹, D. Koliogiannis¹⁰, G. Lurje¹¹, T. Manzia¹², D. Monbaliu¹³, P. Muisean¹⁴, D. Patrono¹⁵, J. Pratschke¹⁶, R. Romagnoli¹⁷, M. Rayar¹⁸, F. Roma¹⁴, A. Schlegel², P. Dutkowski², R. J. Porte¹, V. E. de Meijer¹
¹University Medical Center Groningen, Groningen, Netherlands, ²University Hospital Zurich, Zurich, Switzerland, ³ASST Papa Giovanni XXIII, Bergamo, Italy, ⁴ASST Grande Ospedale Metropolitano Niguarda, Niguarda, Italy, ⁵Niguarda Ca’ Granda Hospital, Niguarda, Italy, ⁶Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy, ⁷Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy, ⁸University of Munich, Munich, Germany, ⁹Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, ¹⁰Hospital of the University of Munich, Munich, Germany, ¹¹Charité Universitätsmedizin Berlin, Berlin, Germany, ¹²Tor Vergata University, Rome, Italy, ¹³KU Leuven University Hospitals Leuven, Leuven, Belgium, ¹⁴Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, ¹⁵A. O. U. Città della Salute e della Scienza di Torino, Turin, Italy, ¹⁶Charite Universitatsmedizin Berlin, Berlin, Germany, ¹⁷AOU Città della Salute e della Scienza di Torino, Turin, Italy, ¹⁸CHU Pontchaillou, Rennes, France
*Purpose: A short period (1-2 hours) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver…