Am J Transplant, Volume 22, Suppl 3 Archives - Page 119 of 190 - ATC Abstracts

2022 American Transplant Congress
Liver Transplant Recipient Gender and Race: Impact on Clinical Outcomes
M. M. French¹, R. Mangus¹, R. Holmes¹, A. Krause¹, J. Sumner¹, C. Kubal², B. Ekser³, P. Mihaylov⁴, J. Fridell⁵, A. Lutz⁶
¹Department of Surgery, Indiana University, Indianapolis, IN, ²Department of Surgery, Indiana University Hospital, Indianapolis, IN, ³Surgery, Indiana University - Transplant Surgery, Indianapolis, IN, ⁴Department of Surgery, Indiana Univ School of Medicine, Indianapolis, IN, ⁵Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, ⁶Indiana University, Fishers, IN
*Purpose: Background. Health disparities are present in transplantation. This is a retrospective review of liver transplant (LT) recipients determining the impact of race/gender on early…
2022 American Transplant Congress
Direct Comparison of Clinical Outcomes with Belatacept-Based Regimens to Calcineurin Inhibitors Among DCD and/or High KDPI Kidney Transplant Recipients
A. Rizvi¹, M. Kueht², S. Hussain³, J. Fair², R. Ramirez⁴, A. Gamilla-Crudo⁵, M. Mujtaba⁵
¹Internal Medicine, Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX, ²Surgery, University of Texas Medical Branch, Galveston, TX, ³University of Texas Medical Branch, Houston, TX, ⁴Surgery, University of Texas Medical Branch at Galveston, Galveston, TX, ⁵University of Texas Medical Branch, Galveston, TX
*Purpose: Belatacept, an inhibitor of the T-cell costimulatory pathway, can be used in recipients of Donation after Cardiac Death (DCD) and high Kidney Donor Profile…
2022 American Transplant Congress
Antibody Responses to an Additional Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients with and without HIV
M. Saksena¹, G. Carrara², B. Haydel², A. Azad¹, K. Srivastava¹, C. Gleason¹, K. Beach¹, L. Sominsky¹, A. Oostenink¹, G. Cai¹, J. Carreno Quiroz¹, G. Singh¹, S. Florman², C. Cordon-Cardo³, J. Aberg⁴, A. Wajnberg⁵, F. Krammer¹, V. Simon¹, M. Rana⁴
¹Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Recanati/Miller Transplantation Institute, Mount Sinai Hospital, New York, NY, ³Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Solid organ transplant (SOT) recipients mount suboptimal immune responses to a two-dose SARS-CoV-2 mRNA vaccine series. Data regarding antibody responses in HIV and SOT…
2022 American Transplant Congress
Donor Black Race Modifies the Association Between Increasing Donor Age and Graft Failure Following Living Kidney Transplantation
K. Atiemo, R. Baudier, A. Anderson
Tulane University, New Orleans, LA
*Purpose: Transplantation utilizing Black living donor kidneys is associated with poorer outcomes.A possible explanation is genetic(APOL1). Kidneys from healthy older Black donors are considered lower…
2022 American Transplant Congress
Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration
N. M. Ali¹, S. Mehta¹, V. Tatapudi¹, A. Mattoo¹, I. Soomro¹, J. Benstein¹, H. Neumann¹, F. Zervou¹, J. Miles², R. Montgomery¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, CA
*Purpose: Evolving data suggests booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccines in solid organ transplant recipients with higher IgG responses, neutralizing antibodies titers,…
2022 American Transplant Congress
Identification Of A Novel Peripheral Blood Six-gene Signature Diagnosing Subclinical Acute Rejection After Renal Transplantation
H. Zhang, Y. Xu, Y. Wang, X. Hu
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Given the insensitivity and nonspecificity of serum creatinine, invasive surveillance biopsies are the main way to detect subclinical acute rejection (subAR) in the absence…
2022 American Transplant Congress
Ex Vivo End Ischemic Hypothermic Oxygenated Perfusion (hope) Versus Static Cold Storage Prior To Liver Transplantation – Preliminary Results Of The Bridge To Hope Pivotal Multicenter Randomized Controlled Clinical Trial On The Safety And Effectiveness Of The Vitasmart Liver Machine Perfusion System (clinicaltrials.gov: Nct05045794)
D. J. Reich¹, A. Schlegel², M. Rizzari³, D. Foley⁴, M. DeVera⁵, W. Chapman⁶, G. Roll⁷, A. Saharia⁸, C. Quintini⁹, S. Florman¹⁰, S. Merani¹¹, S. Mao¹², A. Pinna¹³, M. Akoad¹⁴, C. Kubal¹⁵, S. Alexopoulos¹⁶, H. Bohorquez¹⁷
¹Drexel University, Philadelphia, PA, ²Careggi U, Florence, Italy, ³Henry Ford, Detroit, MI, ⁴U Wisconsin, Madison, WI, ⁵Loma Linda, Loma Linda, CA, ⁶Washington U, Saint Louis, MO, ⁷UCSF, SF, CA, ⁸Methodist, Houston, TX, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Mount Sinai, NY, NY, ¹¹U Nebraska, Omaha, NE, ¹²Mayo, Jacksonville, FL, ¹³Cleveland Clinic, Weston, FL, ¹⁴Lahey, Burlington, MA, ¹⁵Indiana U, Indianapolis, IN, ¹⁶Vanderbilt, Nashville, TN, ¹⁷Ochsner, New Orleans, LA
*Purpose: Ex vivo end ischemic hypothermic oxygenated machine perfusion (HOPE) is a simple technique to improve liver transplant (LT) results and the donor shortage. HOPE…
2022 American Transplant Congress
Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach
H. Tejeda Mora¹, J. Willemse², Y. den Hartog¹, I. Schurink², M. M. Verstegen², J. de Jonge², R. C. Minnee², M. W. van den Hoogen², C. C. Baan¹, L. J. van der Laan², M. J. Hoogduijn¹
¹Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ²Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
2022 American Transplant Congress
Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8⁺ T Cells That Persist Despite Corticosteroids and ATG Therapy
A. L. Peters¹, G. Begum¹, K. Roskin², E. Woodle³, D. Hildeman⁴
¹Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Department of Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Department of Surgery, University of Cincinnati, Cincinnati, OH, ⁴Department of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Conventional therapy for liver transplant rejection (corticosteroids and ATG) has remained unchanged for six decades, and is not infrequently met with treatment failure. Here,…
2022 American Transplant Congress
Chronic Ethanol Exposure Prolongs Murine Allograft Survival
D. Swift, M. Ford, W. Kitchens
Department of Surgery, Emory University, Atlanta, GA
*Purpose: Alcoholic liver disease is the leading indication for liver transplantation in the United States, and patients are increasingly transplanted without the traditional six month…