Am J Transplant, Volume 22, Suppl 3 Archives - Page 114 of 190 - ATC Abstracts

2022 American Transplant Congress
Antibody and Cellular Immunity After Primary mRNA Vaccination in Adolescents with Stable Liver or Liver-Inclusive Intestine Allografts
G. Mazariegos¹, C. Ashokkumar², K. Soltys², M. Michaels², G. Bond², A. Khanna², M. Ningappa², P. Morgan², R. Sindhi²
¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, ²Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA
*Purpose: Transplant recipients experience lower seroconversion rates after COVID-19 vaccination compared with healthy adults and have been prioritized to receive booster doses. To assess pre-…
2022 American Transplant Congress
Noninvasive Biomarkers for Allograft Monitoring After Intestinal Transplantation: Promising Early Results from a Novel Peptide, REG3α
C. P. Smullin¹, R. S. Venick², E. A. Marcus², B. V. Naini³, D. G. Farmer⁴
¹David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ²Pediatrics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ³Pathology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, ⁴Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
*Purpose: There is an urgent need for the discovery and application of noninvasive biomarkers to detect allograft rejection after intestinal transplantation (ITx). Calprotectin and citrulline…
2022 American Transplant Congress
Sigma-1 Receptor Agonists Are Protective in a Rat Model of Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, J. Hodrea¹, L. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better long-term outcomes and quality of life compared to dialysis, but the shortage in donor organs is serious…
2022 American Transplant Congress
Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival
J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…
2022 American Transplant Congress
Personalized Medicine Using Next-Generation Sequence for Kidney Transplant Recipients
J. Sanchez-Garcia, D. Morris, E. Darling, M. Dantis-Tan, J. Olson, K. Gaid, A. Raza, S. Anand
Intermountain Medical Center, Murray, UT
*Purpose: Tissue diagnosis definitely drives therapeutic and prognostic decisions amongst patients with chronic kidney disease (CKD). However, patients with CKD often present late in the…
2022 American Transplant Congress
Vitamin D Deficiency in Liver Transplant Recipients
V. Subramanian¹, T. Lippert², J. Buggs¹, N. Kemmer¹, K. Dhanireddy¹
¹Transplant Institute, Tampa General Hospital, Tampa, FL, ²University of South Florida, Tampa, FL
*Purpose: Patients with chronic liver disease are at risk of nutritional deficiency. The goal of this study was to determine the prevalence of vitamin D…
2022 American Transplant Congress
Optimal Dose of Anti-Thymocyte Globulin to Improve Allograft and Patient Survival After Kidney Transplantation: Analysis from Korean Organ Transplantation Registry Data
Y. Shim, H. Kwon, Y. Kim, H. Kwon, J. Jung, Y. Ko, S. Lim, S. Shin
Surgery, Asan Medical Center, Seoul, Seoul, Korea, Republic of
*Purpose: The optimal dose of anti-thymocyte globulin (ATG) as an induction regimen in Asian kidney recipients is unclear.*Methods: Using Korean Organ Transplantation Registry database, we…
2022 American Transplant Congress
Early Impact of the Mission Act on Utilization of Veterans Affairs Transplant Centers
J. C. Walker¹, C. Roumie², I. D. Feurer³, R. Forbes⁴
¹General Surgery, Vanderbilt University Medical Center (VUMC), Nashville, TN, ²Internal Medicine, VUMC, Nashville, TN, ³Surgery and Biostatistics, VUMC, Nashville, TN, ⁴VUMC, Nashville, TN
*Purpose: The Veterans Affairs (VA) Maintaining Systems and Strengthening Integrated Outside Networks (MISSION) Act of 2018 was implemented in 2019 to increase veteran access to…
2022 American Transplant Congress
Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts
T. Yokose¹, E. S. Szuter¹, M. T. Guinn¹, J. Ge², I. Rosales³, M. Ford⁴, P. S. Russell¹, A. G. Cuenca², J. C. Madsen¹, R. B. Colvin¹, A. Alessandrini¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Boston Children's Hospital, Boston, MA, ³Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁴Department of Surgery, Emory University, Atlanta, GA
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…
2022 American Transplant Congress
Donor-Derived Duodenal Adenocarcinoma of a Bladder-Drained Pancreas Allograft
D. Isaacson¹, J. Steggerda¹, Y. Xue¹, G. B. Auffenberg², N. N. Katariya³
¹Northwestern University, Chicago, IL, ²Urology of St. Louis, St. Louis, MO, ³Mayo Clinic, Phoenix, AZ
*Purpose: Donor-derived malignancies are rare but frequently present with aggressive pathology and high mortality rates [PMID 32627325]. The urologic literature demonstrates an increased risk of…