Am J Transplant, Volume 21, Suppl 3 Archives - Page 83 of 139 - ATC Abstracts

2021 American Transplant Congress
Donor Lymphocytes in Peripheral Blood of Patients After Lung Transplantation Comprise High Frequencies of Killer Cell Immunoglobulin-like Receptor-positive T and NK Cell Subsets
J. F. Kühne¹, A. Hitz¹, K. A. Bläsing¹, B. Wiegmann², R. Bellmàs Sanz¹, F. Ius², A. Haverich², G. Warnecke², C. S. Falk¹
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany
*Purpose: For end-stage lung diseases, lung transplantation (LuTx) is the only curative treatment option. However, acute and chronic rejections are major limitations. Thus, a deeper…
2021 American Transplant Congress
Initial Experience with Growth Hormone Receptor Knockout in Pig-to-Baboon Kidney Transplantation: Effect on Ureteric Viability and Kidney Growth
C. Hansen-Estruch¹, H. Iwase¹, A. Jagdale¹, T. Yamamoto¹, M. H. Bikhet¹, J. Foote², H. Hara¹, D. Anderson¹, P. Porrett¹, D. Eckhoff¹, D. Ayares³, W. Eyestone³, J. Locke¹, D. K. Cooper¹
¹Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Department of Microbiology and Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, ³Revivicor, Blacksburg, VA
*Purpose: The purpose of this study was to report outcomes of pig-to-baboon renal transplants using a novel growth hormone receptor knockout (GHRKO) organ-source pig created…
2021 American Transplant Congress
Caspase-3 is a Predominant Regulator of Microvascular Dysfunction and Aki-ckd Transition Post Renal Ischemia-reperfusion Injury
S. Lan, F. Migneault, J. Turgeon, M. Bourgault, M. Dieudé, N. Patey, H. Cardinal, M. Hébert
CRCHUM, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within tubular epithelial…
2021 American Transplant Congress
Identification and Comprehensive Validation of Prognostic Genes After Ischemic and Reperfusion Injury Across Different Donor Types in Renal Transplantation
D. Zhang, Y. Wang, Y. Wang, X. Hu
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Ischemic and reperfusion injury (IRI) remains an inevitable and major challenge for renal transplant patients. The current study aims to obtain overall insights into…
2021 American Transplant Congress
Impact of Deceased Donor Mode of Death and Kidney Donor Profile Index on Baseline Donor Derived Cell Free DNA in Kidney Transplant Recipients
B. Chopra, A. Grazier, K. K. Sureshkumar
Allegheny Health Network, Pittsburgh, PA
*Purpose: Donor derived-cell free DNA (dd-cfDNA) is a novel serum biomarker available for earlier prediction of acute rejection in renal allograft. Baseline dd-cfDNA values are
2021 American Transplant Congress
Brain Natriuretic Peptide and Pedometer Activity are Most Predictive of Poor Kidney Transplant Waitlist Outcomes
P. Manay¹, P. TenEyck², R. Kalil³, M. Sanders⁴, M. Swee⁴, G. Binns⁵, J. Hornikel⁵, D. Katz¹
¹Department of Surgery, University of Iowa, Iowa City, IA, ²Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA, ³Department of Medicine, University of Maryland Medical Center, Baltimore, MD, ⁴Department of Medicine, University of Iowa, Iowa City, IA, ⁵Iowa City VAMC, Iowa City, IA
*Purpose: Tools for indicating which patients are most at risk for complications and death after transplant listing would allow for a rational approach to targeted…
2021 American Transplant Congress
GENiE in a Bottle – Renasight Testing in the Kidney Transplant Setting – A Single Center Experience
Y. A. Qazi¹, W. Mon¹, N. Ioannou², M. Smogorzewski¹
¹Keck Medical Center at USC, Los Angeles, CA, ²Natera, San Carlos, CA
*Purpose: Renasight™(Natera), a recently available genetic test provides analysis on 382 genes associated with adult-onset kidney disease, covering clinical categories (cystic, tubular, glomerular, complement-related, congenital…
2021 American Transplant Congress
Torque Teno Virus Load Predicts Allograft Rejection but Not Viral Infection After Kidney Transplantation; A Cohort Joint Modelling Study
A. L. van Rijn¹, H. F. Wunderink², I. A. Sidorov¹, C. S. de Brouwer¹, A. C. Kroes¹, H. Putter³, A. P. de Vries⁴, J. I. Rotmans⁴, M. C. Feltkamp¹
¹Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands, ³Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, ⁴Internal Medicine, Leiden University Medical Center, Leiden, Netherlands
*Purpose: The main challenge of immunosuppressive therapy after solid organ transplantation is to find the optimal dose regimen, and prevent allograft rejection as well as…
2021 American Transplant Congress
Impact of Rejection in Pediatric and Young Adult Kidney Transplant Recipients on the Use of Mental Health Resources
E. Ruzicka¹, E. Lyons², C. Naclerio², A. Sikora², K. McKinnon², E. Blanchette², M. Chandran², M. Bock², E. Christofferson²
¹Children's Hospital Colorado, Aurora, CO, ²University of Colorado, Aurora, CO
*Purpose: Allograft rejection often results in increased hospital and medical resource utilization. Pediatric kidney transplant recipients (KTR) are at risk for psychosocial stressors, nonadherence to…
2021 American Transplant Congress
Simultaneous Heart-Liver-Kidney Transplantation Survival: National and Single-Center Outcomes
U. A. Siddiqi¹, P. S. Combs¹, G. Kim², T. Baker³, Y. Becker¹, V. Jeevanandam¹
¹Section of Cardiac Surgery, University of Chicago Medicine, Chicago, IL, ²Section of Cardiology, University of Chicago Medicine, Chicago, IL, ³University of Chicago Medicine, Chicago, IL
*Purpose: Simultaneous Heart-Liver-Kidney transplantation (SHLKTx) is an incredibly rare, high-risk operation undergone by well-selected patients presenting with multi-organ failure. Our center has performed 10 of…