2021 American Transplant Congress
Effects of IL-18 on Key Post-Translational Modifications of Human Foxp3 and Innate Immunity
1CHOP & University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA
*Purpose: Most of our ideas about Treg cells are extrapolated from findings in mice, with actual clinical data typically involving flow cytometric enumeration of CD4+FOXP3+…2021 American Transplant Congress
Proteomic Analysis of Extracellular Vesicles Derived From a Potent Donor-specific Regulatory T Cell-enriched Population Demonstrates Multiple Markers of Immune Suppression
*Purpose: Extracellular vesicles (EVs) are emerging as vital mediators of intercellular communication and immune regulation. Regulatory T cells (Tregs) play an integral role in immune…2021 American Transplant Congress
A Small Molecule Inhibitor of Toll-like Receptor-4 TAK-242 Attenuates IBMIR Against Human Islets
1Baylor University Medical Ctr, Dallas, TX, 2Baylor University, Waco, TX
*Purpose: A large portion of grafted islets are lost shortly after infusion due to the instant blood mediated inflammatory reaction (IBMIR). In our previous studies,…2021 American Transplant Congress
An Immune-modulatory Strategy to Mitigate Hepatic Ischemia/reperfusion Injury in a Murine Model
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…2021 American Transplant Congress
Myeloid Yap Signaling is Required for Hepatic Cytoprotection in Liver Ischemia-reperfusion Injury
*Purpose: Liver ischemia-reperfusion injury (IRI) is recognized as an innate immunity-driven local inflammation response during hemorrhagic shock, liver resection and transplantation. Yes-associate protein 1 (YAP)…2021 American Transplant Congress
Evaluation of Meningococcal Vaccine Response Among Solid Organ Transplant Recipients Receiving Eculizumab
*Purpose: Patients receiving eculizumab are at a 1,000-2,000-fold increased risk of invasive meningococcal infections. Therefore, the Advisory Committee for Immunization Practices recommends that these patients…2021 American Transplant Congress
Leukopenia in the Renal Transplant Population
1Emory University, Atlanta, GA, 2Surgery, Emory University, Atlanta, GA
*Purpose: Leukopenia is a common complication for transplant patients on immunosuppression, but etiologies, timing, and outcomes are only superficially understood.*Methods: All patients undergoing kidney transplant…2021 American Transplant Congress
Continuation of Immunosuppression After the First Renal Allograft Failure Impacts Panel Reactive Antibody Status During Subsequent Renal Transplantation
*Purpose: The standard of care following renal allograft failure is to discontinue immunosuppression (IS) to limit risks from further IS. We hypothesized that continuation of…2021 American Transplant Congress
Is Subclinical Allograft Rejection by 2019 Banff Criteria Associated with Worse Kidney Allograft Outcomes? Comparison Between 2007 and 2019 Banff Criteria
*Purpose: We hypothesize that Subclinical Acute Rejection (SubAR) under the new Banff 2019 criteria will be more strongly associated with a 2-year composite endpoint (2Y-CCE)…2021 American Transplant Congress
“A New Lease on Life”: Patient Perceptions After Early Liver Transplantation for Alcohol-Related Liver Disease
*Purpose: At some centers, alcohol-related liver disease (ARLD) patients, who are unlikely to survive six months without a liver transplant (LT), are selected to receive…
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