Am J Transplant, Volume 21, Suppl 3 Archives - Page 74 of 139 - ATC Abstracts

2021 American Transplant Congress
Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells
C. Albert¹, L. G. Bracaglia¹, A. Koide², J. DiRito¹, T. Lysyy¹, C. Edwards¹, J. T. Langford¹, D. Haakinson¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober¹, W. M. Saltzman¹, S. Kiode², G. Tietjen¹
¹Yale University, new haven, CT, ²Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, ³University of Cambridge, Cambridge, United Kingdom
*Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
2021 American Transplant Congress
IFNγ, and to a Lesser Extent TNFα, Elicits Protracted Endothelial Cell Expression of Costimulatory Molecules and Antigen Presentation Machinery
N. M. Valenzuela
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Beyond simply “recruiting” leukocytes to sites of injury, local stimulation by the donor vascular compartment may prolong alloimmune responses. Moreover, the dynamics of endothelial…
2021 American Transplant Congress
Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation
R. Qin¹, J. Qin², C. Sun³, B. Nashan¹
¹Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, ²Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, ³Division of Life and Medicine, University of Science and Technology of China, Hefei, China
*Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
2021 American Transplant Congress
Distinct Phenotype and Function of Antibody-suppressor Cxcr5⁺Cd8⁺ T Cells
J. Zimmerer, J. Han, M. Hart, S. Chaudhari, C. Peterson, G. Bumgardner
OSU, Columbus, OH
*Purpose: We have reported that the novel subset of antibody-suppressor CD8+ T cells (termed CD8+ TAb-supp cells) require the expression of CXCR5. In addition, alloprimed…
2021 American Transplant Congress
Lacripep^TM-like Peptide N-104 Increases Insulin Secretion and Promotes Islet Transplantation Outcomes
M. Ma, P. Chhabra, K. Dias Teixeira, G. Laurie, K. Brayman
University of Virginia Health System, Charlottesville, VA
*Purpose: To study if LacripepTM-like peptide N-104 promotes beta-cell stabilization and islet transplantation outcomes. Background: Lacritin is a multifunctional tear protein with prosecretory, prosurvival and…
2021 American Transplant Congress
Sigma-1 Receptor Agonists are Renoprotective in Experimental Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, D. Balogh¹, J. Hodrea¹, L. J. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a…
2021 American Transplant Congress
Characterization of Kidney Small Extracellular Vesicles Released During Normothermic Machine Perfusion
W. W. Woud¹, A. Arykbaeva², D. de Vries², I. Alwayn², K. Boer¹, C. Baan¹, M. Hoogduijn¹, R. Minnee³
¹Internal Medicine, Nephorology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Department of Surgery, LUMC, Leiden, Netherlands, ³Department of Surgery, Division of Hepato-Pancreato-Biliary and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands
*Purpose: By characterizing and quantifying the dynamical release of kidney Extracellular Vesicles (EVs) during Normothermic Machine Perfusion (NMP), we aim to gain a better understanding…
2021 American Transplant Congress
Longitudinal Surveillance, Relative Change Value (RCV) Improve Diagnostic Test Accuracy (DTA) of Donor-Derived Cell Free DNA (dd-cfDNA)
S. Anand, F. Lopez-Verdugo, J. Sanchez-Garcia, L. Dong, M. Fife, J. Krong, D. Morris, T. Srinivas
Intermountain Medical Center, Murray, UT
*Purpose: dd-cfDNA, an injury biomarker in kidney transplant (KTx), is emerging as a trigger for biopsy (Bx) and superior to the traditional trigger of change…
2021 American Transplant Congress
Characteristics, Risk Factors, and Outcomes of Neutropenia for the First Year After Liver or Kidney Transplantation in Children
C. Jarasvaraparn¹, S. Choudhury², C. Rusch², K. Liss¹, J. Stoll¹, S. Hmiel³, S. Kulkarni¹
¹Pediatric Gastroenterology, Washington University School in St Louis, Saint Louis, MO, ²Pediatric, Washington University School in St Louis, Saint Louis, MO, ³Pediatric Nephrology, Washington University School in St Louis, Saint Louis, MO
*Purpose: Prior studies in adults have shown that approximately 20-38 % of subjects undergoing solid organ transplant develop neutropenia. In the current study, we characterized…
2021 American Transplant Congress
Immunosuppression Impacts Panel Reactive Antibody Status in Second Solid Organ Transplant Recipients – A Single Center Experience
J. Patel¹, S. Ali², M. L. Sanders¹, C. P. Thomas¹, D. Axelrod¹, M. Bilal³, E. H. Field³, S. Kuppachi¹
¹University of Iowa Hospitals & Clinics, Iowa city, IA, ²Louis A. Johnson VA Medical Center, Clarksburg, WV, ³Iowa City VA Health Care System, Iowa city, IA
*Purpose: Patients who require a second solid organ transplantation are significantly disadvantaged due to the event of sensitization due to the first transplant. We hypothesized…