Am J Transplant, Volume 21, Suppl 3 Archives - Page 71 of 139 - ATC Abstracts

2021 American Transplant Congress
Kidney Paired Donation in Pediatrics: An Underused Opportunity?
J. Smith¹, M. Skeans², R. Engen³, S. Bartosh⁴
¹Seattle Children's Hospital, Seattle, WA, ²SRTR, Minneapolis, MN, ³Lurie Children's Hospital, Chicago, IL, ⁴Univ of Wisconsin, Madison, WI
*Purpose: Kidney paired donation (KPD) provides the opportunity for ABO-mismatched or HLA-incompatible pairs to receive a living donor kidney transplant. The superior graft survival among…
2021 American Transplant Congress
Assessing the Accuracy of the Lung Allocation Score
N. Dussault¹, W. Parker¹, R. Jablonski¹, E. Garrity¹, M. Churpek²
¹University of Chicago, Chicago, IL, ²University of Wisconsin-Madison, Madison, WI
*Purpose: The Lung Allocation Score (LAS) relies on the performance of two cox proportional hazards models that estimate waitlist and post-transplant survival. These models were…
2021 American Transplant Congress
Comparison of Outcomes of Hepatitis C Virus (hcv) Nucleic Acid (nat) Positive Donor Between Hcv-naïVe and Hcv + Recpients – A Donor Mate Analysis
J. Kamal, B. Sharma, A. Doyle, A. Kumar, A. Nishio-Lucar, S. Rao
University of Virginia, Charlottesville, VA
*Purpose: Despite a growing mismatch between organ need and supply, organs from HCV+ donors were only offered to HCV+ recipients (HCV R+) to avoid complications…
2021 American Transplant Congress
Anti-CD8 Immuno-PET for Non-invasive Tracking of Early Graft Rejection in a Non-human Primate Kidney Transplant Model
K. Bruestle¹, R. Tavare², F. Fredriksson¹, E. Duggan¹, F. Huang¹, B. Bhola¹, J. Giurleo², R. Foster², P. Krueger², M. Dobosz², D. Ekanayake-Alper¹, H. Sakai¹, B. Piegari¹, J. Castrillion¹, S. M. Coley¹, O. Harari², A. Mintz¹, D. Ma², A. Griesemer¹
¹Columbia University Medical Center, New York City, NY, ²Regeneron Pharmaceuticals, Inc, New York City, NY
*Purpose: Infiltration of CD8 T cells into solid organ grafts is an early sign of rejection. REGN5054 is a fully human monoclonal antibody that binds…
2021 American Transplant Congress
Validation of a Novel Gene Expression Biomarker of Rejection Following Liver Transplantation
J. Levitsky¹, M. Kandpal¹, T. Whisenant², K. Guo¹, S. Kurian³, M. Abecassis⁴
¹Gastroenterology & Hepatology; Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²University of California San Diego, San Diego, CA, ³Scripps Clinic, La Jolla, CA, ⁴University of Arizona College of Medicine Tucson, Tucson, AZ
*Purpose: Non-invasive biomarkers distinguishing early signs of immune activation vs. quiescence could more objectively guide immunosuppression management after liver transplantation (LT). Our aim was to…
2021 American Transplant Congress
The Rate of Hospitalization Among Patients with Cirrhosis is More Than Twice as High as Patients Over 85 Years
N. R. Mazumder¹, K. Guo², L. Zhao³, A. Kho¹, K. Walters⁴, T. S. Carey⁴, C. Loftus¹, D. P. Ladner¹
¹Northwestern Memorial Hospital, Chicago, IL, ²Biostatistics, Northwestern Memorial Hospital, Chicago, IL, ³Biostatistcs, Northwestern Memorial Hospital, Chicago, IL, ⁴University of North Carolina Chapel Hill, Chapel Hill, NC
*Purpose: Cirrhosis is a common disease however it is understudied because population data on patients with cirrhosis is lacking. While the risk of hospitalization in…
2021 American Transplant Congress
Economic and Clinical Benefit of Cmv Matching in Kidney Transplantation
D. Axelrod¹, S. Chang², A. Olyaei³, D. Malinoski³, D. Norman³, K. Lentine⁴, M. Schnitzler⁴, D. Segev⁵, J. Lockridge³
¹Univ of Iowa, Iowa City, IA, ²Washington Univ, Seattle, WA, ³Oregon Health Sciences Univ, Portland, OR, ⁴Saint Louis Univ, Saint Louis, MO, ⁵Johns Hopkins, Baltimore, MD
*Purpose: Recently, kidney transplant (KTx) centers in Oregon collaborated to preferentially allocate cytomegalovirus-seronegative (CMV D-) kidneys to seronegative recipients (CMV R-), successfully reducing high-risk CMV…
2021 American Transplant Congress
Desensitization Using Clazakizumab® (anti-il-6) in Highly-hla Sensitized Patients Awaiting Kidney Transplant (nct03380962)
A. A. Vo¹, N. Ammerman¹, E. Huang¹, M. Toyoda², S. Ge², A. Peng¹, R. Najjar¹, S. Sethi¹, S. Williamson¹, C. Myers¹, K. Lim¹, M. Gillespie¹, S. Jordan¹
¹Kidney Transplant, Cedars Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 is a critical cytokine for plasma cell IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6. Here…
2021 American Transplant Congress
Impact of Transplant Center Volume on Utilization of and Outcomes Following Donation After Circulatory Death Liver Transplantation in the United States
S. Kumar¹, S. Lin², J. D. Schold²
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ²Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Despite increased utilization of donation after circulatory death (DCD) grafts in the US, impact of center volume on DCD liver transplantation (LT) remains unclear.…
2021 American Transplant Congress
Liver Simulated Allocation Model Does Not Accurately Predict Organ Offer Decisions in Pediatric Liver Transplant Candidates
N. L. Wood¹, D. B. Mogul², E. K. Hsu³, E. R. Perito⁴, G. V. Mazariegos⁵, D. Vanderwerken¹, D. L. Segev², S. Gentry¹
¹US Naval Academy, Annapolis, MD, ²Johns Hopkins, Baltimore, MD, ³Univ of Washington, Seattle, WA, ⁴UCSF, San Francisco, CA, ⁵Univ of Pittsburgh, Pittsburgh, PA
*Purpose: The U.S. relies on the Scientific Registry of Transplant Recipient’s (SRTR’s) Liver Simulated Allocation Model (LSAM) to predict the effect of allocation policy changes…