Am J Transplant, Volume 21, Suppl 3 Archives - Page 68 of 139 - ATC Abstracts

2021 American Transplant Congress
Tip60 Inhibitors Enhance Regulatory T Cells (Treg) Induction by Promoting Acetylation of Foxp3
F. Fueyo-Gonzalez¹, G. Vilanova², M. Fribourg¹
¹Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ²LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain
*Purpose: TIP60, a histone/protein acetyltransferase essential for multiple functions in the cell, is involved in Foxp3 acetylation in Treg. Acetylation protects Foxp3 from degradation, and…
2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
S. Q. Crome¹, J. M. Szusz², C. McEvoy¹, J. An¹, S. Clotet-Freixas¹, S. A. MacParland¹, G. D. Bader³, A. Konvalinka¹
¹Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network and the University of Toronto, Toronto, ON, Canada, ²Immunology, University of Toronto, Toronto, ON, Canada, ³Molecular Genetics, University of Toronto, Toronto, ON, Canada
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…
2021 American Transplant Congress
Cold Perfusion for Ischemia Minimization Reduces Cardiac Injury in an Ex Vivo Xenoperfusion Model
M. R. Connolly¹, A. Calhoun¹, F. Pollok¹, L. Burdorf¹, Z. Habibabady¹, M. Ma¹, S. Miura¹, W. Eyestone², C. Phelps², D. Ayares²
¹Massachusetts General Hospital, Boston, MA, ²Revivicor, Blacksburg, VA
*Purpose: Prior studies using Steen’s cold perfusion storage technique for heart ischemia minimization (IM) prevented initial xenograft dysfunction (IXD). Our pilot data evaluates the effect…
2021 American Transplant Congress
Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation
H. Kojima¹, H. Hirao¹, K. Kadono¹, T. Ito¹, K. J. Dery¹, S. Kageyama², K. Nakamura³, F. M. Kaldas¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Kyoto University, Kyoto, Japan, ³Nishi-Kobe Medical Center, Kyoto, Japan
*Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…
2021 American Transplant Congress
Glycogen Synthase Kinase 3 Beta Regulates Distinctive Macrophage Subsets in the Activation and Resolution of Liver Ischemia Reperfusion Injury
H. Zhang¹, M. Ni², J. Zhang¹, H. Wang², R. Busuttil¹, J. Kupiec-Weglinski¹, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Glycogen synthase kinase 3β (Gsk3β) differentially regulates pro- and anti-inflammatory programs in macrophages upon TLR stimulations. We have documented in a murine liver partial…
2021 American Transplant Congress
Comparative Proteomics Analysis Identifies the Biomarker of Ischemia-Reperfusion Injury During Liver Transplantation
M. Chen¹, L. Xiaohong², H. Xitao¹, J. Weiqiang¹
¹Transplant Center, Sun Yat-sen University, Guangzhou, China, ²Sun Yat-sen University, Guangzhou, China
*Purpose: To a large extent the success of liver transplantation depends on quality of allografts. The molecular basis of the susceptibility of different liver allografts…
2021 American Transplant Congress
Incidence of Pancreatic Exocrine Insufficiency in Patients Undergoing Liver Transplantation
J. Klein¹, M. Rangel¹, I. Ifearulundu¹, Y. Gely¹, Z. Spigel², S. Janardhan³, M. Hertl¹, E. Chan¹
¹Surgery, Rush University Medical Center, Chicago, IL, ²Surgery, Allegheny Health Network, Pittsburgh, PA, ³Hepatology, Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study was to determine the incidence of Pancreatic Exocrine Insufficiency (PEI) in patients undergoing liver transplantation. Furthermore, patient-specific risk factors…
2021 American Transplant Congress
The Role of the B2 Microglobulin Trend in Patients with Delayed Graft Function After Kidney Transplant
A. Perez-Gutierrez, P. J. Bachul, B. Juengel, P. Witkowski, D. DiSabato, R. Barth, J. Fung, Y. Becker
Surgery, University of Chicago, Chicago, IL
*Purpose: Delayed graft function (DGF) is associated with worse short and long-term outcomes after kidney transplantation. There is a lack of biomarkers to predict outcomes…
2021 American Transplant Congress
Identification and Validation of a Prognostic Index for Renal Allograft Survival Based on the Geo Database
X. Zhang, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Chronic allograft injury (CAI) following kidney transplantation is still a threat to the allograft long-term survival. This study was designed to explore and analyze…
2021 American Transplant Congress
The Lived Experience of Older Adult Kidney Transplant Recipients: Reflections on Embodied Selfhood in Later Life
L. Kimberly
New York University Langone Health, New York, NY
*Purpose: Although the number of older adults who might benefit from kidney transplantation continues to increase in the United states, little is known about older…