2021 American Transplant Congress
Impact of Lung Allocation Score Cohort Update
1SRTR, Minneapolis, MN, 2Univ of Washington, Seattle, WA, 3Cleveland Clinic, Cleveland, OH
*Purpose: The lung allocation score (LAS) was last revised in February, 2015, based on waitlist (WL) and posttransplant (PT) survival model cohorts from 2006-2008 and…2021 American Transplant Congress
Utility of Non-Invasive Rejection Biomarkers to Guide Immunomodulation in Kidney Transplant Patients with Active Covid-19 Infection
*Purpose: Treatment of Coronavirus Disease 2019 (COVID-19) infection in organ transplant recipients has involved reduction of immunosuppression (IS). It is plausible that the cytokine release…2021 American Transplant Congress
Development of Diagnosis Method of Acute Graft Rejection After Kidney Transplantation Using Metabolome Analysis by Liquid Biopsy Approach
*Purpose: Presently, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy procedure…2021 American Transplant Congress
Mortality in Organ Transplant Recipients with Covid-19 Compared to Non-transplant or Waitlisted Patients: A Meta-analysis
Rhode Island Hospital/Brown University, Providence, RI
*Purpose: Organ transplant recipients (OTR) are considered at high risk for adverse outcomes from COVID-19. However, mortality rates range from 30%. Some studies found that…2021 American Transplant Congress
TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation
Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…2021 American Transplant Congress
Conversion to Belatacept Based Immunosuppression Regimen in Kidney Transplant Patients: Lessons Learned
*Purpose: The costimulatory inhibitor, belatacept (Bela) has been shown to be an effective alternative in several clinical situations including calcineurin toxicity, de novo alloantibody formation…2021 American Transplant Congress
Degree of T Cell Infiltration Predicts Treatment Response in Pediatric Liver Late Acute Cellular Rejection
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Late acute cellular rejection (ACR) occurs >6mo post-liver transplant and is associated with chronic rejection and allograft loss. Currently, no diagnostic features predict ACR…2021 American Transplant Congress
A Comparison of Pediatric Intestine Transplant Between the Current Era (2015-2019) and the Peak Period (2002-2006)
1Seattle Children's Hospital, Seattle, WA, 2SRTR, Minneapolis, MN
*Purpose: Demand for intestine transplants in children grew from its clinical inception in the late 1980s to a peak in 2007 of 111 small bowel-containing…2021 American Transplant Congress
T-Cell Exhaustion in EBV DNAemic Solid Organ Transplant Recipients
Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: In transplant recipients, disease severity after infection with Epstein-Barr virus (EBV) may range from asymptomatic DNAemia to PTLD. Host factors likely play a key…2021 American Transplant Congress
Racial and Sexual Disparities in Solid Organ Transplant Outcomes Since Implementation of the Affordable Care Act Insurance Expansion Across Some States
*Purpose: Achieving solid organ transplantation traditionally requires access to health insurance. As such, women and people of color have faced barriers to obtaining solid-organ transplants.…
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