Am J Transplant, Volume 21, Suppl 3 Archives - Page 56 of 139 - ATC Abstracts

2021 American Transplant Congress
Belatacept for Kidney Transplantation in the Age of Covid19, is it Safe?
J. Pagan¹, S. Anjan², Y. Natori³, A. Fernandez³, R. Zamora-Gonzalez², A. Mattiazzi¹, L. Mendez¹, G. Guerra¹
¹Nephrology, University of Miami, Miami, FL, ²Infectious Diseases, University of Miami, Miami, FL, ³Infectious Disease, University of Miami, Miami, FL
*Purpose: The COVID19 pandemic has affected kidney transplant recipients (KTR) with a wide spectrum of clinical severity. Up to this point, we have solely seen…
2021 American Transplant Congress
Frailty and Short-Term Outcomes in Kidney Transplant
S. Van Arsdale¹, K. Torbert¹, R. Harland², A. Turner², B. Tanriover³, V. Ariyamuthu³
¹Banner University Medical Center, Tucson, AZ, ²Surgery, Banner University Medical Center, Tucson, AZ, ³Internal Medicine, Banner University Medical Center, Tucson, AZ
*Purpose: Studies suggest worse outcomes for frail solid organ transplant recipients. We analyzed post transplant outcomes in relation to frailty.*Methods: We conducted a retrospective study…
2021 American Transplant Congress
Pharmacokinetic and Toxicity Studies of an Anti CD40L Antibody, At-1501 in Rhesus Macaques
S. Perrin¹, A. Gill², C. Gill², F. Vieira², K. Thompson²
¹Novus Therapeutics, Irvine, CA, ²ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory receptor for CD40 found on T helper cells. Binding of CD40L on T cells to CD40 on antigen presenting cells…
2021 American Transplant Congress
Targeting Il-21 Receptor Shifts Tfh/tfr Balance and Ameliorateschronic Antibody Mediated Rejection
Y. Nian, Z. Xiong, J. Zhao, Y. Fu
Tianjin First Central Hospital, Tianjin, China
*Purpose: Donor specific antibody (DSA) plays a central role in chronic kidney allograft injury. As a trigger of humoral alloimmune response, follicular T helper cells(Tfh)…
2021 American Transplant Congress
The Tumor-suppressor Signaling of the α1-na/k-atpase- Cav-1-src Complex at the Caveola in Nash Related Hepatocellular Carcinoma
U. S. Udoh¹, J. D. Sanabria¹, M. Banerjee¹, P. K. Rajan¹, M. Schade¹, J. A. Sanabria¹, A. Mallick¹, G. Smith¹, G. U. Udoh², K. Sodhi¹, S. Pierre², Z. Xie², J. Shapiro², J. Sanabria¹
¹Dept. of Surgery/ Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV, ²Marshall Institute for Interdisciplinary Research, Marshall University, Huntington,, WV
*Purpose: Hepatocellular Carcinoma (HCC) is the 2nd and fastest-growing cause of cancer related mortality worldwide, mainly from the metabolic cellular disturbances promoted by the epidemic…
2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
A. Dangi¹, S. Yu², I. Husain¹, R. Geesala¹, X. Luo¹
¹Nephrology, Medicine, Duke University, Durham, NC, ²Division of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…
2021 American Transplant Congress
Establishing a Linear Program for the Development of Costimulation Resistant T-Cells
D. P. Moris, A. Lucander, A. Kirk
Surgery, Duke, Durham, NC
*Purpose: CD4+CD57+PD1-T-cells are primed effectors capable of mediating belatacept-resistant rejection, however, the developmental program giving rise to these cells has not been elucidated in detail.…
2021 American Transplant Congress
Anti-HLA-DP Antibodies Positive – A Retrospective Review of Outcomes in Renal Transplantation- Single Centre Experience
O. Piscoran¹, J. Worthington², R. Dhillon¹, T. Augustine¹, M. Picton¹, M. Morton¹, S. Bhutani¹
¹Urology, Renal and Transplantation, Manchester University NHS Foundation Trust, Manchester, United Kingdom, ²Transplantation Laboratory, Manchester University NHS Foundation Trust, Manchester, United Kingdom
*Purpose: Data on the role of HLA-DP antibodies on graft outcome is not precise. Studies suggested that the presence of donor-directed HLA-DP antibodies correlate with…
2021 American Transplant Congress
MiRNA as Regulator of Cell Death and Inflammatory Response in Hepatic Iri
E. Bardhi¹, T. Rousselle¹, J. McDaniels¹, S. Bontha¹, J. Eason², D. Maluf¹, V. Mas³
¹Surgery, University of Maryland, Baltimore, MD, ²Surgery, James D Eason Transplant Institute, Memphis, TN, ³Surgery, University of Maryland - Division of Surgical Science, Baltimore, MD
*Purpose: Hepatic IRI represents a barrier to the use of available organs. Early graft dysfunction of donor livers is directly related to the severity of…
2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…