Am J Transplant, Volume 21, Suppl 3 Archives - Page 56 of 139 - ATC Abstracts

2021 American Transplant Congress
Cleveland Clinic Experience with Cadaveric Uterus Transplant
L. Del Prete¹, C. Quintini¹, K. Hashimoto¹, B. Eghtesad¹, G. D'Amico¹, C. Kwon¹, D. Priebe¹, E. Richards¹, S. Ricci¹, U. Perni¹, C. Ferrando¹, A. Chiesa-Vottero¹, S. Mawhorter¹, N. Yeaney¹, R. Farrell¹, R. Flyckt², C. Miller¹, T. Falcone¹, A. Tzakis¹
¹Cleveland Clinic, Cleveland, OH, ²University Hospital, Cleveland, OH
*Purpose: Uterus transplantation (UTx) is the only treatment for women with uterine factor infertility (UFI). The majority of overall experience is from living donation. Little…
2021 American Transplant Congress
Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients
S. Chandran¹, K. Mason², L. F. Sun¹, N. Tanimine³, M. DesMarais¹, B. Burrell¹, J. F. Markmann³
¹ITN, San Francisco, CA, ²Rho, Inc., Durham, NC, ³MGH, Boston, MA
*Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…
2021 American Transplant Congress
Compatible Paired Donation in Paired Kidney Exchange: A Look at the Road Not Taken
G. Vranic, A. Gilbert, B. Thomas, S. Ghasemian, M. Cooper, J. Verbesey
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Paired kidney exchange (PKE) offers incompatible donor-recipient pairs increased access to transplant. Compatible pairs are increasingly joining the PKE in an effort to find…
2021 American Transplant Congress
Impact of the Covid-19 Pandemic on Transplant Pharmacist Workforce
J. Lyons¹, K. Khalil², J. J. Teuteberg³, E. J. Henricksen⁴
¹Department of Pharmacy, Loyola University Medical Center, Maywood, IL, ²Department of Pharmacy, NYU Langone Health, New York, NY, ³Medicine and Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Stanford University, Stanford, CA, ⁴Department of Transplant, Stanford Health Care, Stanford, CA
*Purpose: Evaluate the impact of the COVID-19 pandemic on the transplant pharmacist workforce.*Methods: A voluntary survey open from August 18, 2020 to September 15, 2020…
2021 American Transplant Congress
Peri-operative Liver Transplant Anesthesia Practice Patterns in the United States
C. Crouch¹, A. Hendrickse¹, W. Stoll², C. Sullivan³, M. Kaufman⁴, E. Pivalizza⁵, D. Damian⁶, D. Sellers⁷, M. Little⁸, S. McCluskey⁷, S. Kumar⁹, L. De Marchi¹⁰, S. Sridhar⁵, T. Sakai⁶
¹Department of Anesthesiology, University of Colorado, Aurora, CO, ²Medical University of South Carolina, Charleston, SC, ³Emory University, Atlanta, GA, ⁴Lahey Health, Burlington, MA, ⁵University of Texas Health Science Center at Houston, Houston, TX, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of Toronto, Toronto, ON, Canada, ⁸University of Texas Health Science Center San Antonio, San Antonio, TX, ⁹University of Michigan, Ann Arbor, MI, ¹⁰Georgetown University, Washington DC, DC
*Purpose: Transplant anesthesiology is an evolving subspecialty and has not been the subject of an overall review of practice patterns in the United States since…
2021 American Transplant Congress
Lung Transplant Recipients Developing Early DSAs are Characterized by a Shift Towards Memory B Cells Directly After Transplantation
S. Christoph¹, A. Hitz¹, R. Bellmàs Sanz¹, J. Kühne¹, B. Wiegmann², F. Ius², J. Salman², E. Chichelnitskiy¹, T. Siemeni², W. Sommer³, A. Haverich², G. Warnecke³, C. Falk¹
¹Institute of Transplant Immunology, MHH, Hannover, Germany, ²Department of Cardiothoracic, Transplant and Vascular Surgery, MHH, Hannover, Germany, ³Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany
*Purpose: After lung transplantation (LTx), the development of early donor HLA-specific antibodies (eDSA) is associated with antibody-mediated rejection (AMR) and poor graft survival. Since 2013,…
2021 American Transplant Congress
Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys
J. R. DiRito¹, G. Chickering², J. T. Langford¹, D. Stern¹, S. Hosgood³, M. L. Nicholson³, E. Gavathiotis⁴, R. N. Kitsis⁵, M. Saltzman², J. S. Pober⁶, G. T. Tietjen⁷
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT, ³Surgery, University of Cambridge, Cambridge, United Kingdom, ⁴Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, ⁵Surgery, Albert Einstein College of Medicine, Bronx, NY, ⁶Immunobiology, Yale University, New Haven, CT, ⁷Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT
*Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
2021 American Transplant Congress
Microbial Signatures Promote Antibiotic-Mediated Alleviation of Peritransplant Liver Damage in Mouse Recipients
K. J. Dery¹, S. Kageyama¹, H. Hirao¹, H. Kojima¹, K. Kadono¹, T. Dong², J. W. Kupiec-Weglinski¹
¹The Dumont-UCLA Transplantation Center, Los Angeles, CA, ²Department of Medicine, Vatche & Tamar Manoukian Division of Digestive Diseases, UCLA, Los Angeles, CA
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
2021 American Transplant Congress
The Absence of T Follicular Regulatory Cells Prolongs Germinal Center Reactivity in Transplantation
E. S. Crichton, S. Zeng, I. Badell
Emory University, Atlanta, GA
*Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
2021 American Transplant Congress
Estrogen Receptors Alpha and Beta are Required for Immune Homeostasis and Normal Treg Function
L. M. Christensen¹, T. Akimova², G. Ge³, R. Han¹, L. Wang¹, P. Hernandez³, C. O'Brien³, M. H. Levine³, W. W. Hancock¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
*Purpose: Estrogen signaling is a critical component of mammalian homeostasis, acting through a complex and interconnected system of hormone synthesis pathways and receptor signaling cascades.…