Am J Transplant, Volume 21, Suppl 3 Archives - Page 37 of 139 - ATC Abstracts

2021 American Transplant Congress
Impact of Transplant Center Volume on Utilization of and Outcomes Following Donation After Circulatory Death Liver Transplantation in the United States
S. Kumar¹, S. Lin², J. D. Schold²
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ²Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Despite increased utilization of donation after circulatory death (DCD) grafts in the US, impact of center volume on DCD liver transplantation (LT) remains unclear.…
2021 American Transplant Congress
Liver Simulated Allocation Model Does Not Accurately Predict Organ Offer Decisions in Pediatric Liver Transplant Candidates
N. L. Wood¹, D. B. Mogul², E. K. Hsu³, E. R. Perito⁴, G. V. Mazariegos⁵, D. Vanderwerken¹, D. L. Segev², S. Gentry¹
¹US Naval Academy, Annapolis, MD, ²Johns Hopkins, Baltimore, MD, ³Univ of Washington, Seattle, WA, ⁴UCSF, San Francisco, CA, ⁵Univ of Pittsburgh, Pittsburgh, PA
*Purpose: The U.S. relies on the Scientific Registry of Transplant Recipient’s (SRTR’s) Liver Simulated Allocation Model (LSAM) to predict the effect of allocation policy changes…
2021 American Transplant Congress
Growing LDLT Volumes at a US Center- What Does It Take to Do Over 100 LDLTs Per Year
A. Humar, C. Hughes, G. Mazariegos, K. Soltys, A. Gallatin, K. Emmett, A. Tevar, M. Molinari, A. Ganoza, V. Gunabushanam, S. Ganesh
University of Pittsburgh, Pittsburgh, PA
*Purpose: LDLT remains underutilized in the US, accounting for
2021 American Transplant Congress
Effective Patient Throughput on the Transplant Surgery Service
E. M. Thomas¹, P. K. Shah¹, S. Beasley², A. Saad¹, M. Rani¹, F. Cigarroa¹
¹UT Health San Antonio, San Antonio, TX, ²University Health, San Antonio, TX
*Purpose: Hospital bed capacity and patient throughput are persistent challenges for medical centers. One established strategy for increasing patient throughput and decompressing Emergency Departments is…
2021 American Transplant Congress
The Role of Donor-derived Cell-free DNA to Detect Subclinical Acute Rejection in Kidney Allograft
S. Park¹, K. Guo², R. Heilman³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁹, J. Holman¹⁰, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹¹, J. Friedewald¹
¹Transplant nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Transplant nephrology, Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Eurofins US Clinical Diagnostics, Lee’s Summit, MO, ¹⁰Transplant Genomics, Inc, Mansfield, MA, ¹¹University of Arizona College of Medicine, Northwestern University, Tucson, AZ
*Purpose: We hypothesized that donor-derived cell-free DNA (dd-cfDNA) could detect subclinical acute rejection (subAR).*Methods: 429 blood samples paired with surveillance kidney biopsies from 208 patients…
2021 American Transplant Congress
Inflammation in Scarred Cortex (i-IFTA) is Significantly Associated with T Cell-mediated Rejection (TCMR), but Not Antibody-mediated Rejection (ABMR), in Renal Allograft Biopsies (Bx)
H. Zhang
Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: I-IFTA in renal allograft Bx has been found to be associated with decreased death-censored graft survival. Moderate to severe i-IFTA (2 or 3) is…
2021 American Transplant Congress
Effect of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Individual Level and Within Twenty Five Race/ethnic Groups
H. C. Copley¹, L. Gragert², A. R. Leach³, V. Kosmoliaptsis¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom, ²Department of Pathology, Tulane University School of Medicine, New Orleans, LA, ³European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom
*Purpose: Development of adaptive immunity after COVID-19 and after vaccination against SARS-CoV-2 is predicated on recognition of viral peptides, presented on HLA class II molecules,…
2021 American Transplant Congress
TOLS are Novel Regulatory TLOs with A B Cell Signature
I. Rosales¹, Q. Yuan¹, C. Yang¹, P. Russell¹, J. Madsen¹, A. Alessandrini¹, R. Colvin¹, -. AA and RC²
¹Massachusetts General Hospital, Boston, MA, ²Co-Senior Authors, Boston, MA
*Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…
2021 American Transplant Congress
Immunosuppression and Cancer Risk in Kidney Transplant Recipients: A Retrospective Cohort Study
R. Sapir-Pichhadze¹, C. Laprise¹, X. Zhang¹, M. Abrahamowicz¹, M. Beauchamp², A. Della Vecchia¹, L. Azoulay¹, E. Franco¹, B. Nicolau¹
¹McGill University, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada
*Purpose: Kidney transplant recipients (KTR) have an elevated risk of cancer. We sought to estimate to what extent does the immunosuppression regimen increase KTRs’ susceptibility…
2021 American Transplant Congress
Are All DSA’s the Same? Are We Ready for Precision Medicine in Pediatric LT?
S. E. Shin¹, M. Lee¹, N. Yazigi², K. Khan², S. Kaufman², J. Ahn³, O. Timofeeva⁴, U. Ekong²
¹Georgetown University School of Medicine, Washington, DC, ²Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC, ³Biostatistics, Bioinformatics, & Biomathematics, Georgetown University, Washington, DC, ⁴Histocompatibility Laboratory, Dept. of Pathology & Laboratory Medicine, Georgetown University, Washington, DC
*Purpose: Donor-specific antibodies (DSA) play an uncertain role in rejection after liver transplantation (LT). We hypothesized that evaluation of epitope differences in HLA-DR/DQ mismatching can…