Am J Transplant, Volume 21, Suppl 3 Archives - Page 37 of 139 - ATC Abstracts

2021 American Transplant Congress
Worsening Impact of Acute Kidney Rejection on Long Term Graft Survival from 2000 to 2014
D. Leeser¹, W. Irish¹, K. Ravindra², V. Villani², A. Connor², J. Tuttle¹
¹Surgery, East Carolina University, Greenville, NC, ²Surgery, Duke University, Durham, NC
*Purpose: Acute rejection (AR) has been shown to impact graft survival after kidney transplant (KTx), however there is limited data on its impact on long…
2021 American Transplant Congress
Impact Analysis of Virtual Transplant Ambulatory Pharmacist During Covid-19
L. Park, G. Waldman, J. Kim, C. Rogers, J. Clark
Massachusetts General Hospital, Boston, MA
*Purpose: During the COVID-19 pandemic, transplant centers were challenged to meet the demand for new telemedicine strategies. High-risk immunocompromised patients, such as lung transplant recipients…
2021 American Transplant Congress
Response to a Pandemic: The Fall and Rise of Kidney Transplantation in the US
S. Bisen¹, B. Boyarsky¹, W. Werbel¹, J. Snyder², J. Garonzik-Wang¹, D. Segev¹, A. Massie¹
¹JHU, Baltimore, MD, ²SRTR, Minneapolis, MN
*Purpose: During the first wave of the COVID-19 epidemic in March-April 2020, waitlist registrations and living/deceased donor kidney transplants (LDKT/DDKT) dropped substantially. A second wave…
2021 American Transplant Congress
The Initial Impact of Covid-19 on Reported Graft Failure Rates and Potential Confounding of Srtr Psrs
A. Wey¹, J. Miller¹, D. Musgrove¹, Y. Ahn¹, M. Valapour², N. Salkowski¹, M. Skeans¹, A. Massie³, R. Hirose⁴, D. Segev³, A. Israni¹, J. Snyder¹, B. Kasiske¹
¹SRTR, Minneapolis, MN, ²Cleveland Clinic, Cleveland, OH, ³Johns Hopkins, Baltimore, MD, ⁴Univ of California, San Francisco, San Francisco, CA
*Purpose: COVID-19 could bias the Scientific Registry of Transplant Recipients (SRTR) program-specific reports (PSRs), especially if its impact varied geographically.*Methods: Recipients who received transplants from…
2021 American Transplant Congress
High Levels of Donor-Derived Cell-Free DNA Predict EGFR Decline After Kidney Transplantation
T. Alhamad¹, V. Bowers², E. Stites³, S. Anand⁴, J. S. Bromberg⁵, H. Murad¹, G. Gupta⁶, I. Moinuddin⁶, L. Bu⁷, S. Ghosh⁸, J. Zeng⁸, A. Pai⁹
¹Washington University in St. Louis, St. Louis, MO, ²Tampa General Hospital, Tampa, FL, ³University of Colorado, Aurora, CO, ⁴Intermountain Medical Center, Murray, UT, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Virginia Commonwealth University, Richmond, VA, ⁷University of Minnesota, Minneapolis, MN, ⁸CareDx, Brisbane, CA, ⁹University of Texas McGovern Medical School, Houston, TX
*Purpose: Persistent, low-grade inflammation is associated with decline in eGFR. Cross-sectional studies have demonstrated a consistent association between circulating inflammatory markers and kidney function. Our…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
2021 American Transplant Congress
A Mechanistic Evaluation to Guide the Optimal Immunosuppression Adjustment Strategy in Transplant Patients with COVID-19
V. Hall, V. Ferreira, D. Kumar, A. Humar
UHN, Toronto, ON, Canada
*Purpose: The optimal management of immunosuppression in transplant patients infected with COVID-19 is unknown. Reduction in calcineurin inhibitors or antimetabolite doses is often performed in…
2021 American Transplant Congress
LTβR Engagement Regulates Treg Migration, Stability and Suppressor Function
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, M. W. Shirkey¹, J. Iyyathurai¹, R. Lakhan¹, R. Abdi², J. Bromberg¹
¹U Maryland, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Treg stimulate lymphotoxin…
2021 American Transplant Congress
Evaluation of a Weight-Based Mycophenolate Mofetil Dosing Protocol for Kidney Transplant Maintenance Immunosuppression
M. Mahoney¹, E. Kincaide¹, J. Nelson¹, K. Klein¹, R. Hall¹, S. Bhayana²
¹University Health, San Antonio, Department of Pharmacotherapy and Pharmacy Services, The University of Texas at Austin, Pharmacotherapy Division, College of Pharmacy, San Antonio, TX, ²University Transplant Center, University Health, San Antonio, Department of Nephrology, The University of Texas Health Science Center at San Antonio, San Antonio, TX
*Purpose: To evaluate the safety and efficacy of a weight-based mycophenolate mofetil (MMF) dosing protocol in adult kidney transplant recipients (KTR).*Methods: This single-center retrospective study…
2021 American Transplant Congress
The Pediatric National Liver Review Board: What Happens to Waitlist Registrations with Denied Exception Forms?
J. Foutz¹, C. Martinez¹, A. Henderson¹, E. K. Hsu², E. R. Perito³, J. Heimbach⁴
¹United Network for Organ Sharing, Richmond, VA, ²Seattle Children's Hospital, Seattle, WA, ³UCSF, San Francisco, CA, ⁴Mayo Clinic, Rochester, MN
*Purpose: On 5/14/19, the exceptions review process for pediatric liver transplant (LT) candidates was changed from 11 Regional Review Boards to one National Pediatric Liver…