ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Basiliximab versus Alemtuzumab: The Association Between Induction Agent and Airway Complications Following Lung Transplantation

    M. Furukawa1, E. G. Chan1, T. Harano1, J. Ryan1, R. Rivosecchi2, M. R. Morrell1, P. G. Sanchez1

    1Cardiothoracic Surgery, UPMC, Pittsburgh, PA, 2PUH-Pharmacy, UPMC, Pittsburgh, PA

    *Purpose: Controversy still exist regarding the best induction strategy for lung transplantation. At our institution, induction is defined based on donor recipient CMV match. While…
  • 2021 American Transplant Congress

    Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts

    V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
  • 2021 American Transplant Congress

    Cytomegalovirus (CMV) D+/R- Serostatus is Independently Associated with Mortality and Graft Loss After Liver Transplantation (LTx)

    P. Vutien, J. Perkins, S. Biggins, J. Reyes, A. Limaye

    Internal Medicine, University of Washington Medical Center, Seattle, WA

    *Purpose: It is unknown if donor or recipient (D/R) CMV serostatus, in the era of CMV prophylactic and pre-emptive strategies, remains associated with clinical outcomes…
  • 2021 American Transplant Congress

    Relationship of Functional Frailty and Radiographic Sarcopenia to Outcomes After Liver Transplant

    S. L. Olson, P. Polineni, W. Schwartz, O. Siddiqui, L. Zhao, D. Ganger, D. P. Ladner

    Comprehensive Transplant Center, Northwestern University, Chicago, IL

    *Purpose: Frailty and sarcopenia are associated with increased risk of hospitalization and mortality in end stage liver disease patients. Frailty can be measured clinically using…
  • 2021 American Transplant Congress

    P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts

    H. Tsuda, A. Valujskikh, R. Fairchild

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…
  • 2021 American Transplant Congress

    Coexistence of BKPyV Lytic Infection and Viral Integration in the Development of BKPyV Diseases After Renal Transplantation

    S. Yan1, Y. Wang1, Y. Liu1, W. Deng1, Z. Yan1, J. Xu1, C. Wu2, Y. Miao1

    1Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Departments of Urology & Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    *Purpose: To understand the role of BK Polyomavirus (BKPyV) infection and integration in the pathogenesis of BKPyV-associated diseases.*Methods: Sixteen patients with BKPyV-associated diseases were included,…
  • 2021 American Transplant Congress

    Low Socio-economic Status is Associated with Lower Kidney Graft Survival and Increased Risk of Graft Failure Due to Acute Rejection

    W. Xie1, G. Vrakas1, S. H. Gray1, A. Haririan2, J. R. Scalea1, J. S. Bromberg1, D. G. Maluf1, R. P. Meier1

    1Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Department of Medicine, University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Low socio-economic status (SES) has been shown to be associated with poor kidney graft outcomes. We aimed to characterize differences in high and low…
  • 2021 American Transplant Congress

    Life-supporting Multi-gene Cardiac Xenografts From Swine Demonstrate Survival >8 Months and Preclinical Efficacy for Human Clinical Trials

    C. Goerlich1, B. Griffith1, A. Singh1, T. Zhang1, I. Tatarov1, B. Lewis1, F. Sentz1, A. Hershfeld1, P. Odonkor1, B. Williams1, E. Strauss1, A. Tabatabai2, A. Bhutta3, D. Ayares4, D. Kaczorowski1, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, 3Pediatrics, Pediatric Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, 4Revivicor, Inc., Blacksburg, VA

    *Purpose: Cardiac xenotransplantation has been proposed to bridge the gap in organ shortage for those in end-stage heart failure without the opportunity to receive a…
  • 2021 American Transplant Congress

    Short-term Therapy with Anti-icam-1 Monoclonal Antibody Induced Long-term Liver Allograft Survival in Non-human Primates

    S. Hong1, D. Han2, S. Lee2, J. Kim3, E. Hwang3, H. Kim4, J. Lee5, K. Hong1, E. Han1, J. Cho1, J. Lee1, Y. Choi1, K. Lee1, N. Yi1, J. Yang1, K. Suh1

    1Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of, 3Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of, 4Pathology, Seoul National University College of Medicine, Seoul, Korea, Republic of, 5Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Tolerance induction remains challenging following liver transplantation and the long-term use of immunosuppressants, especially calcineurin inhibitors, leads to serious complications. We aimed to test…
  • 2021 American Transplant Congress

    Extreme Phenotype Sampling and Next Generation Sequencing to Identify Genetic Variants Associated with Tacrolimus Metabolism in African American Kidney Transplant Recipients

    C. R. Dorr1, B. Guo2, B. Wu2, J. Abrahante2, D. Schladt3, R. Remmel2, W. Guan2, A. Muthusamy3, G. Onyeaghala3, N. Pankratz2, A. Matas2, R. Mannon4, W. Oetting2, P. Jacobson2, A. K. Israni3

    1Hennepin Healthcare Research Institute, Minneapolis, MN, 2University of Minnesota, Minneapolis, MN, 3Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, 4University of Nebraska Medical Center, Omaha, NE

    *Purpose: Tacrolimus (TAC) pharmacogenomics studies identified common genetic variants that alter TAC troughs suggesting strategic dosing for specific populations. Common variants and clinical factors explain…
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