ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    High Levels of Sars-cov-2 Detected in Immunosuppressed Covid-19 Patient Environments Weeks Following Initial Positive Test

    C. E. Kuschner1, Z. Brune2, L. B. Becker1, L. Teperman1

    1North Shore University Hospital, Manhasset, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY

    *Purpose: COVID-19 is a novel viral illness associated with significantly worse mortality, prolonged disease course, and extended periods of viral shedding in transplant patients on…
  • 2021 American Transplant Congress

    T-cell-Mediated Immunity to Sars-cov-2 Defines Covid-19 Risk and Severity in Transplanted and Non-Transplanted Individuals and Associates with Myeloid-Derived Suppressor Cells

    C. Ashokkumar1, V. Rohan2, A. H. Kroemer3, S. Rao4, G. Mazariegos5, B. W. Higgs5, S. Nadig2, M. Ningappa5, T. Fishbein3, S. Subramaniam6, R. Sindhi7

    1Plexision, Pittsburgh, PA, 2Medical University of South Carolina, Charleston, SC, 3MedStar Georgetown Transplant Institute, Georgetown, DC, 4DHR Health Institute for Research and Development, Texas, TX, 5University of Pittsburgh, Pittsburgh, PA, 6University of California, San Diego, CA, 7University of Pittsburgh, pittsburgh, PA

    *Purpose: We assessed whether COVID-19-risk is enhanced by chronic immunosuppression, and is associated with suppressor cells.*Methods: We tested 66 COVID-19 patients, including 26 with solid…
  • 2021 American Transplant Congress

    Allocating Kidneys in Optimized Circles: Logistics are More Important Than Distance

    R. Saidi, R. Shahbazov, M. Hanlon, M. laftavi

    SUNY Upstate, Syracuse, NY

    *Purpose: The OPTN recently proposed removing Donation Service Area (DSA) and regional boundaries used in the current kidney allocation system (KAS) and allocate organs within…
  • 2021 American Transplant Congress

    Adult Combined Liver-Heart Transplantation: The United States Experience

    I. A. Ziogas1, S. P. Alexopoulos1, W. K. Wu1, L. K. Matsuoka1, M. A. Rauf1, M. Izzy2, R. Perri2, K. H. Schlendorf3, J. N. Menachem3, A. S. Shah4

    1Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, 2Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, 3Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, 4Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN

    *Purpose: Combined heart-liver transplantation (CHLT) is now being practiced with increasing regularity and improved outcomes in the United States. We performed the most comprehensive review…
  • 2021 American Transplant Congress

    Predictors of Severe Covid-19 in Kidney Transplant Recipients in the First and Second Waves: Analysis of the Spanish Registry

    M. Crespo1, A. Mazuecos2, I. Pérez-Flores3, F. Moreso4, A. Andrés5, C. Jimenez6, M. Molina7, C. Canal8, L. Sánchez-Cámara9, S. Zárraga10, M. Ruiz Fuentes11, M. Aladrén12, E. Melilli13, V. López14, E. Sanchez15, J. Pascual for Spanish Nephro Society Covid-Registry1

    1Nephrology, Hospital del Mar, Barcelona, Spain, 2Nephrology, Hospital Puerta del Mar, Cadiz, Spain, 3Nephrology, Hospital Clinico San Carlos, Madrid, Spain, 4Nephrology, Hospital Valle Hebrón, Barcelona, Spain, 5Nephrology, Hospital 12 Octubre, Madrid, Spain, 6Nephrology, Hospital La Paz, Madrid, Spain, 7Nephrology, Hospital Germans Trias i Pujol, Barcelona, Spain, 8Nephrology, Fundacio Puigvert, Barcelona, Spain, 9Nephrology, Hospital Gregorio Marañón, Madrid, Spain, 10Nephrology, Hospital de Cruces, Bilbao, Spain, 11Nephrology, Hospital Virgen de las Nieves, Granada, Spain, 12Nephrology, Hospital Miguel Servet, Zaragoza, Spain, 13Nephrology and Kidney Transplantation, Hospital de Bellvitge, Barcelona, Spain, 14Nephrology, Hospital Regional de Málaga, Malaga, Spain, 15Nephrology, Hospital de Cabueñes, Gijon, Spain

    *Purpose: To better know the impact and characteristics of Covid-19 in renal patients, the Spanish Society of Nephrology set up a voluntary registry in March,…
  • 2021 American Transplant Congress

    Hla Antigens and Recurrence of Focal Segmental Glomerulosclerosis in Pediatric Kidney Transplantation

    B. I. Shaw1, A. Ochoa2, C. Chan2, R. A. Gbadegesin3, A. M. Jackson1, E. T. Chambers3

    1Surgery, Duke University, Durham, NC, 2Biostatistics and Bioinformatics, Duke University, Durham, NC, 3Pediatrics, Duke University, Durham, NC

    *Purpose: Recurrence of focal segmental glomerulosclerosis (FSGS) reduces graft survival yet risk factors remain elusive. While HLA risk alleles are known to be associated with…
  • 2021 American Transplant Congress

    Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss

    M. D. Parkes1, P. F. Halloran2, K. M. Halloran3, &. the INTERLUNG Study Group4

    1Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, 2Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 3University of Alberta, Edmonton AB, AB, Canada, 4., ., AB, Canada

    *Purpose: Chronic lung allograft dysfunction (CLAD) portends poor outcomes yet is poorly understood. In the multi-center INTERLUNG study we measured transcripts in transbronchial biopsies (TBBs)…
  • 2021 American Transplant Congress

    Characterizing the Early Impact of the Kidney Accelerated Placement Project on Hard-to-place Kidneys

    J. D. Motter, A. Kernodle, M. Levan, D. Segev, J. Garonzik-Wang, A. Massie

    Johns Hopkins University, Baltimore, MD

    *Purpose: In 2019, the OPTN implemented the Kidney Accelerated Placement Project (KAPP) in an effort to increase the utilization of kidneys with a high Kidney…
  • 2021 American Transplant Congress

    DCD Heart Donation: Impact on Organ Yield

    K. Gauntt, B. Carrico, D. Klassen

    United Network for Organ Sharing, Richmond, VA

    *Purpose: Recent advances in technology and recovery procedures has enabled donation after circulatory death (DCD) heart donation resulting in a significant increase in the number…
  • 2021 American Transplant Congress

    Identification of Distinct Blood Monocyte Phenotypes from Transplant Kidney Recipients Undergoing Cellular (TCMR) and Mixed Antibody Mediated Rejection (ABMR)

    C. Macedo, E. Bailly, K. Louis, M. Lucas, A. Zeevi, P. Randhawa, D. Metes

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Monocytes play an important role in immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate (CD14+CD16+),…
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