Am J Transplant, Volume 21, Suppl 3 Archives - Page 22 of 139 - ATC Abstracts

2021 American Transplant Congress
The Absence of T Follicular Regulatory Cells Prolongs Germinal Center Reactivity in Transplantation
E. S. Crichton, S. Zeng, I. Badell
Emory University, Atlanta, GA
*Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…
2021 American Transplant Congress
Estrogen Receptors Alpha and Beta are Required for Immune Homeostasis and Normal Treg Function
L. M. Christensen¹, T. Akimova², G. Ge³, R. Han¹, L. Wang¹, P. Hernandez³, C. O'Brien³, M. H. Levine³, W. W. Hancock¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
*Purpose: Estrogen signaling is a critical component of mammalian homeostasis, acting through a complex and interconnected system of hormone synthesis pathways and receptor signaling cascades.…
2021 American Transplant Congress
Bone Marrow-Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating Isl1
W. Ying, J. Wang, X. Ding
Kidney Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi An, China
*Purpose: Revascularization of the transplant islet is a crucial step that defines the success rate of patient recovery. Though bone marrow-derived mesenchymal stem cells (BMSCs)…
2021 American Transplant Congress
Nanodiamond-doxorubicin Complexes Improve Hepatic Ischemia/reperfusion Injury
A. Kobayashi, C. Grady, S. Duarte, V. Boominathan, S. Shrestha, A. Zarrinpar
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major inflammatory event in liver transplantation that is mediated by oxidative stress. Doxorubicin (DOX) can mitigate oxidative stress…
2021 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptor Tyrosine Kinases in Liver Ischemia/reperfusion Injury
J. Zhang¹, H. Zhang¹, M. Ni², R. Busuttil¹, J. Kupiec-Weglinski¹, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Liver Suyrgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
2021 American Transplant Congress
Single Center Experience Comparing Two Clinically Available Donor Derived Cell Free DNA Tests
S. Bunnapradist¹, S. Lee², P. Homkrailas³, G. Danovitch³
¹UCLA, Los Angeles, CA, ²Pharmacy, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Donor derived cell-free DNA (dd cf-DNA), this new technology allows for non-invasive monitoring of graft function. Two most commonly used assays are Prospera (Natera®,…
2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
J. Kang¹, L. Belyayev¹, O. Aguirre¹, K. Khan¹, Y. Gusev², K. Bhuvaneshwar², H. Ressom³, J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Georgetown University Medical Center, Innovation Center for Biomedical Informatics, Washington, DC, ³Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…
2021 American Transplant Congress
Donor-Derived Cell-Free DNA Performance Characteristics are Similar for Repeat and Primary Kidney Transplant Recipients
V. R. Peddi¹, S. Akkina², S. C. Jordan³, W. Tian⁴, Y. Qazi⁵
¹California Pacific Medical Center, San Francisco, CA, ²Loyola University Medical Center, Maywood, IL, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴CareDx, Brisbane, CA, ⁵University of Southern California, Los Angeles, CA
*Purpose: Repeat kidney transplants (RKT) represent 12.4% of kidney transplants (KT) (10.9% of all living donor and 13.6% of all deceased donor). Most RKT are…
2021 American Transplant Congress
Long-term Outcomes of Early Steroid Withdrawal (SW) After Kidney Transplant
D. Vock¹, A. Matas²
¹University of Minnesota School of Public Health, Minneapolis, MN, ²University of Minnesota Medical School, Minneapolis, MN
*Purpose: Early SW (10 years) graft failure associated with early SW.*Conclusions: We conclude that early SW has similar or better long-term outcomes than maintenance prednisone.
2021 American Transplant Congress
Anonymous Live Liver Donor Perspectives on Anonymity in the Donation Process
S. S. Humar, N. Selzner, J. Jung, S. Krause, S. Abbey
Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Anonymous living organ donation has recently become a more regular practice in select transplant programs, with donors coming forward voluntarily to give their organs…