Am J Transplant, Volume 21, Suppl 3 Archives - Page 19 of 139 - ATC Abstracts

2021 American Transplant Congress
A Multimodal Interrogation of Human Renal Allografts
D. Dadhania¹, R. Ding¹, H. Xu², C. Lee¹, C. Snopkowski¹, T. Salinas¹, T. Muthukumar¹, J. Lee¹, R. Woodward², M. Grskovic², S. Dholakia², M. Suthanthiran¹
¹Weill Cornell Medicine - NYPH, New York, NY, ²CareDx, New York, NY
*Purpose: Development and validation of noninvasive biomarkers of kidney allograft rejection should improve transplant outcomes. CTOT-04 study validated urinary cell mRNA signature (CTOT04-Sig) for T-cell…
2021 American Transplant Congress
Prevalence of Diabetic Changes on Kidney Allograft Biopsies of Normoglycemic Simultaneous Pancreas-Kidney Transplant Recipients
C. Mejia, G. Giannini, D. C. Brennan, A. Rosenberg, S. Alasfar
Johns Hopkins University, Baltimore, MD
*Purpose: Small studies suggest that achieving normoglycemia with simultaneous pancreas-kidney transplant (SPK) prevents the development of diabetic nephropathy (DN) among type 1 diabetics (T1DM). However,…
2021 American Transplant Congress
Multiplexed Imaging Mass Cytometry of the Alloimmune Landscape of Rejection in Clinical Liver Transplantation
J. Emamaullee, N. Ung, C. Man, J. Hoeflich, C. Goldbeck, A. Barbetta, R. Sun, N. Matasci, J. Katz, J. Lee, S. Chopra, L. Sher, S. Asgharzadeh, O. Akbari, Y. Genyk
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Imaging Mass Cytometry (IMC) is an emerging preclinical technique…
2021 American Transplant Congress
An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types
L. Hidalgo¹, I. Martinez Juarez², L. Morales Buenrostro², S. Shojai³, P. Campbell¹
¹University of Wisconsin Madison, Madison, WI, ²Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubrian, Mexico City, Mexico, ³Medicine, University of Alberta, Edmonton, AB, Canada
*Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…
2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
J. Torrealba, S. Moore, S. Sathirareuangchai, L. De Las Casas, Q. Cai
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…
2021 American Transplant Congress
Outcomes of Kidney Transplantation in HIV Positive Highly Sensitized Recipients
S. Karhadkar, J. Panichella, H. Resweber, K. Nguyen, A. Di Carlo, S. Karhadkar
Temple University School of Medicine, Philadelphia, PA
*Purpose: Since the introduction of highly active antiretroviral therapy, HIV+ individuals are living longer, which has led to higher rates of end stage renal disease…
2021 American Transplant Congress
The Effect of Delayed Graft Function on Early versus Late Mortality Following Kidney Transplantation
W. Irish¹, Y. Fu², D. B. Leeser¹, K. V. Ravindra³, C. Haisch¹, J. Tuttle¹
¹Surgery, East Carolina University, Greenville, NC, ²Mathematics, East Carolina University, Greenville, NC, ³Surgery, Duke University, Durham, NC
*Purpose: Delayed graft function (DGF) is associated with increased risk of long-term graft survival but it’s impact on patient survival has not been studied. Using…
2021 American Transplant Congress
Elexacaftor/ivacaftor/tezacaftor in Lung Transplant Recipients: A Case Series
L. M. Potter¹, B. Vargas², S. M. Rotolo¹, C. McEwen¹, K. Tsui¹
¹University of Chicago Medicine, Chicago, IL, ²Roosevelt University, Chicago, IL
*Purpose: Little data is published describing the safety or efficacy of elexacaftor/ivacaftor/tezacaftor in lung transplant recipients. Even though it is not expected to offer pulmonary…
2021 American Transplant Congress
Towards National Organ Sharing: Fair Distribution of Eplets in Canada
S. Parto, B. Liu, W. Klement, S. Oikonomopoulos, I. Ragoussis, R. Sapir-Pichhadze
McGill University, Montreal, QC, Canada
*Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…
2021 American Transplant Congress
Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model
M. Manook¹, W. Flores², R. Schmitz¹, Z. Fitch¹, J. Yoon¹, Y. Bae¹, B. I. Shaw¹, M. Harnois³, S. Permar³, A. Kirk¹, D. Magnani², J. Kwun¹, S. Knechtle¹
¹Duke Transplant Center, Duke University Medical Center, Durham, NC, ²Massbiologics, University of Massachusetts Medical School, Boston, MA, ³Human Vaccine Institute, Duke University Medical Center, Durham, NC
*Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…