Am J Transplant, Volume 21, Suppl 3 Archives - Page 135 of 139 - ATC Abstracts

2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
S. Lim, M. Choi, M. Kim, Y. Wee, H. Kwon, C. Jung, Y. Kim, D. Han, S. Shin
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…
2021 American Transplant Congress
Thrombolytic Therapy During Ex-Vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury
O. Haque¹, S. Raigani², I. Rosales², C. Carroll², T. M. Coe², S. Baptista², H. Yeh², K. Uygun², J. F. Markmann²
¹Surgery, Beth Israel Deaconess Medical Center, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: A major limitation in expanding the use of DCD livers in transplantation are the higher rates of graft failure secondary to ischemic cholangiopathy. Warm…
2021 American Transplant Congress
Mitochondrial Transplant Minimizes Liver Ischemia Reperfusion Injury in Lean and Obese Mice
C. Watkins¹, G. Lamanilao¹, C. Kuscu¹, C. Kuscu¹, J. F. Pierre², J. Eason¹, A. Bajwa¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²Department of Pediatrics - Divisions of Neonatology and Pediatric Obesity, The University of Tennessee Health Science Center, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
2021 American Transplant Congress
Longitudinal Variance of Donor Derived Cell Free DNA (dd-cf DNA) in Stable Kidney Transplant (Tx) Patients are Influenced by Donor/Recipient Variables
S. Anand, F. Lopez-Verdugo, J. Sanchez-Garcia, L. Dong, M. Fife, J. Krong, D. Morris, T. Srinivas
Intermountain Medical Center, Murray, UT
*Purpose: The limits and cut offs of dd-cfDNA as an injury biomarker in kidney transplant (KTx) are based on coupled single event (biopsy) measurements. It…
2021 American Transplant Congress
A Reliable Non Invasive Alternative to Surveillance Renal Allograft Biopsy
R. Jain, S. Thaduri, V. Kumar, C. Kew, B. Julian, G. Towns, S. Ong, F. Ahmed, S. Mehta, G. Agarwal
Transplant Nephrology, University of Alabama Birmingham, Birmingham, AL
*Purpose:Surveillance Renal Allograft Biopsy (SAVB) is the standard of care to identify subclinical immunological injury(SCI). However fewer than 25% of transplant centers in the US…
2021 American Transplant Congress
Blood Gene Expression and Donor-derived Cell Free DNA for Diagnosing Subclinical Acute Rejection in Stable Kidney Transplant Recipients
S. Park¹, K. Guo², H. Raymond³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁸, J. Holman⁹, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹⁰, J. Friedewald¹
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Transplant Genomics, Inc, Mansfield, MA, ¹⁰University of Arizona College of Medicine, Tucson, AZ
*Purpose: A blood gene expression profile (GEP) has been established as a non-invasive screen for subclinical acute rejection (subAR). For patients with allograft dysfunction, donor-derived…
2021 American Transplant Congress
Donor Derived Cell-free-dna (dd-cfdna) as a Surrogate Marker for Kidney Biopsy- Indiana University Transplant Nephrology Experience
S. Valavoor¹, A. Sharfuddin², G. William³, M. Yaqub¹, D. Mishler¹, O. Adebiyi²
¹Nephrology, Indiana University, Indianapolis, IN, ²Transplant Nephrology, Indiana University, Indianapolis, IN, ³Transplant Surgery, Indiana University, Indianapolis, IN
*Purpose: Patient monitoring after kidney transplantation (KT) for early detection of allograft rejection remains key in preventing allograft loss. Donor-derived cell-free DNA (dd-cfDNA), a noninvasive…
2021 American Transplant Congress
A Psychosocial Clinician Rating Scale is Used Differently Across Solid Organ Teams within a Single Transplant Center
S. Entenman¹, T. Chaffee², M. Pienta³, B. Young³, E. Clifton¹, J. Mellinger⁴, L. McElroy⁵, G. Winder¹
¹Psychiatry, University of Michigan, Ann Arbor, MI, ²Psychiatry, University of Missouri-Kansas City, Kansas City, MO, ³Surgery, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Surgery, Duke University, Durham, NC
*Purpose: Transplant psychosocial clinician rating scales like the Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) are widely used tools to standardize subjective patient data, stratify…
2021 American Transplant Congress
Right Ventricular Dysfunction After Heart Transplantation: When to Worry?
S. Kim, J. Patel, M. Kittleson, T. Singer-Englar, N. Patel, R. Skorka, D. Chang, E. Kransdorf, M. Hamilton, B. Azarbal, L. Czer, D. Ramzy, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Right ventricular (RV) dysfunction after heart transplantation (HTx) is not uncommon. The cause of RV dysfunction may be due to inadequate preservation, high pulmonary…
2021 American Transplant Congress
Comparison of Outcomes in Sot Recipients During Two Eras of Covid-19 Therapeutics
T. Chiang, A. Sait, A. Massie, K. Marr, D. Brennan, W. Cochran, P. Shah, T. Jain, S. Mehta Steinke, N. Desai, N. Permpalung, S. Shoham, C. Merlo, C. Durand, W. Werbel, M. Dioverti, D. Ostrander, A. Gurakar, M. Y. Kim, J. Garonzik-Wang, D. Segev, R. Avery
Johns Hopkins University, Baltimore, MD
*Purpose: COVID-19 therapies have evolved over time, but little is known regarding outcomes in SOT recipients treated with newer therapeutic agents such as remdesivir, dexamethasone,…