2021 American Transplant Congress
Re-Transplantation of Mouse Kidney Grafts to Study Local Immune Responses
Starzl Transplantation Institution, Pittsburgh, PA
*Purpose: Mouse kidney transplantation has been widely used to study the immune response to allogeneic grafts. This response includes a circulating systemic compartment and a…2021 American Transplant Congress
A Novel Mouse Model of Cardiac Allograft Vasculopathy
*Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…2021 American Transplant Congress
Src Kinase Inhibitor Pp1 Blunts Tgf-β1 Dependent Endothelial‐to‐Mesenchymal Transition to Alleviate Allograft Kidney Fibrosis Through Orchestrating β-catenin Signaling
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Allograft fibrosis is an important contributor to graft loss in chronic renal allograft injury. Endothelial‐to‐mesenchymal transition (EndMT), dysfunction of endothelial cells, played a vital…2021 American Transplant Congress
Recipient Neutrophils Producing Myeloperoxidase Provoke Nk Cell and Monocyte/macrophage Activation During Acute Antibody-mediated Rejection of Kidney Allografts
Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and mediate acute graft rejection. Acute…2021 American Transplant Congress
CRISPR Screens to Map CTLA-4 Regulatory Networks in Primary Human T Cells
1UCSF, San Francisco, CA, 2Stanford University, Stanford, CA
*Purpose: For most cell types, the pathways that regulate the levels of critical disease-relevant genes are not known. Recent advances in gene editing have enabled…2021 American Transplant Congress
The Co-Occurrence of Newly Developed HLA Donor Specific Antibody and Positive C3d/C4d Profiles Along with Immune Therapy Non-Compliance in Pediatric Heart Transplant Recipients is a High Risk Indicator for Patient Mortality
Cleveland Clinic Foundation Transplant Center, Cleveland, OH
*Purpose: Increasing evidence has implicated the deleterious effect of HLA donor specific antibody (DSA) in pediatric heart transplantation (PHTx). However, there are still insufficient research…2021 American Transplant Congress
Indocyanine Green Fluorescence Imaging Allows Quantification of Ischemic Injury During Porcine Normothermic Ex Situ Perfusion
Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Situ Liver Perfusion (NEsLP) is a novel preservation technique for the storage and assessment of grafts retrieved after Donation after Cardio-circulatory Death…2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…2021 American Transplant Congress
Biomarkers of Kidney Injury and Repair in Expanded-Criteria Deceased Donor Kidney Transplant Recipients: A Prospective Study
*Purpose: Expanded-criteria donor (ECD) kidney transplants are at higher risk of kidney injury. Biomarkers that better predict short and long-term outcomes in ECD kidney transplant…2021 American Transplant Congress
The Impact of Maintenance Immunosuppression Withdrawal on Sensitization Status After Renal Graft Failure
SUNY Upstate Medical University, Syracuse, NY
*Purpose: Maintaining immunosuppression (IS) following failed renal transplant may lead to increased risk for infections and malignancies; on the other hand, withdrawal can lead to…
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