2021 American Transplant Congress
T Cell Repertoire Diversity in HCV-Associated Hepatocellular Carcinoma Patients Waitlisted for Liver Transplantation and Receiving Liver-Directed Therapy
Ochsner Health, New Orleans, LA
*Purpose: T cell receptor (TCR) sequencing in hepatocellular carcinoma (HCC) patients revealed a diverse TCR repertoire in hepatitis B-associated HCC-infiltrating T cells. In this study,…2021 American Transplant Congress
A Multimodal Interrogation of Human Renal Allografts
1Weill Cornell Medicine - NYPH, New York, NY, 2CareDx, New York, NY
*Purpose: Development and validation of noninvasive biomarkers of kidney allograft rejection should improve transplant outcomes. CTOT-04 study validated urinary cell mRNA signature (CTOT04-Sig) for T-cell…2021 American Transplant Congress
Prevalence of Diabetic Changes on Kidney Allograft Biopsies of Normoglycemic Simultaneous Pancreas-Kidney Transplant Recipients
Johns Hopkins University, Baltimore, MD
*Purpose: Small studies suggest that achieving normoglycemia with simultaneous pancreas-kidney transplant (SPK) prevents the development of diabetic nephropathy (DN) among type 1 diabetics (T1DM). However,…2021 American Transplant Congress
Multiplexed Imaging Mass Cytometry of the Alloimmune Landscape of Rejection in Clinical Liver Transplantation
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Imaging Mass Cytometry (IMC) is an emerging preclinical technique…2021 American Transplant Congress
An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types
*Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…2021 American Transplant Congress
Outcomes of Kidney Transplantation in HIV Positive Highly Sensitized Recipients
Temple University School of Medicine, Philadelphia, PA
*Purpose: Since the introduction of highly active antiretroviral therapy, HIV+ individuals are living longer, which has led to higher rates of end stage renal disease…2021 American Transplant Congress
The Effect of Delayed Graft Function on Early versus Late Mortality Following Kidney Transplantation
*Purpose: Delayed graft function (DGF) is associated with increased risk of long-term graft survival but it’s impact on patient survival has not been studied. Using…2021 American Transplant Congress
Elexacaftor/ivacaftor/tezacaftor in Lung Transplant Recipients: A Case Series
1University of Chicago Medicine, Chicago, IL, 2Roosevelt University, Chicago, IL
*Purpose: Little data is published describing the safety or efficacy of elexacaftor/ivacaftor/tezacaftor in lung transplant recipients. Even though it is not expected to offer pulmonary…2021 American Transplant Congress
Towards National Organ Sharing: Fair Distribution of Eplets in Canada
McGill University, Montreal, QC, Canada
*Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…
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