2021 American Transplant Congress
IL-10 Signaling in T Cells Modulates Costimulation-independent Activation and is Essential for Transplant Tolerance Induction
*Purpose: Costimulation blockade (CoB)-based immunotherapy remains a very promising approach for better management of transplant recipients. Understanding the mechanisms that impact the efficacy of CoB…2021 American Transplant Congress
Selective Bcl-2 Inhibition to Deplete Hematopoietic Stem Cells in Bone Marrow Niche: A Novel Approach to Promote Mixed Chimerism
*Purpose: A recent murine study has shown that successful mixed chimerism is achievable without myelosuppressive treatments by Bcl-2 inhibition. However, the mechanism by which selective…2021 American Transplant Congress
Imaging Flow Cytometry Reveals That Platelet-Sized Erythrocyte Fragments are Formed During Pig Organ Perfusion with Human Blood
*Purpose: Severe thrombocytopenia frequently occurs after xenotransplantation of porcine cells or organs, and when pig organs are perfused with human blood. We developed a flow…2021 American Transplant Congress
Augmented Responses of Donor Kidney Tubular Cells to TLR Signaling Correlate with Ameliorated Ischemia/reperfusion Injury and Long-term Allograft Protection
*Purpose: We have previously demonstrated that donor genetic background and kidney-intrinsic innate immunity were key determinants of delayed graft function in kidney transplantation. However, the…2021 American Transplant Congress
Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…2021 American Transplant Congress
Association of Immune Cell Markers with Adverse Outcomes in the First 6 Months Post-pediatric Heart Transplantation
*Purpose: Immunosuppression titration post-orthotopic heart transplant (OHT) is limited to trough level monitoring and does not provide data pertaining to overall state of immunosuppression. Additional…2021 American Transplant Congress
De Novo Donor Specific Antibodies After Heart Transplantation in Fontan Patients with Protein Losing Enteropathy
*Purpose: Protein Losing Enteropathy (PLE) complicates Fontan physiology and can be an indication for heart transplantation (HT). PLE is accompanied by immune dysregulation, potentially impacting…2021 American Transplant Congress
Does the Timing of Subclinical Acute Rejection After Kidney Transplant Matter?
*Purpose: We hypothesized that the timing of subclinical acute rejection (subAR) diagnosed with biopsy, gene expression profile or donor-derived cell-free DNA is associated with poor…2021 American Transplant Congress
Nomogram of Quantity of Peripheral Cxcr5+Cd8+ T Cells, Aims to Predict Risk of De Novo Dsa in First-time Kidney Transplant Recipients
1OSU, Columbus, OH, 2Center for Biostatistics, OSU, Columbus, OH
*Purpose: We recently reported that peripheral CXCR5+CD8+ T cells are inversely associated with the risk of developing de novo DSA (dnDSA) in the first year…2021 American Transplant Congress
Two Step Screening for Anxiety Symptoms in Solid Organ Transplant Recipients
University Health Network, Toronto, ON, Canada
*Purpose: Patients with end-stage organ failure who receive organ transplants often experience anxiety symptoms. Currently, however, these symptoms frequently remain un-detected. Systematic screening for anxiety…
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