Am J Transplant, Volume 21, Suppl 3 Archives - Page 105 of 139 - ATC Abstracts

2021 American Transplant Congress
Pilot Study for the Use of Shortened Preemptive Therapy with Glecaprevir/pibrentasvir (g/p) and Ezetimibe in Hepatitis C Seronegative Solid Organ Transplant Recipients (Kidney and Heart) of Hepatitis C Viremic Donors
B. Aqel¹, H. Khamash², A. Moss³, D. E. Steidley⁴, R. C. Dickson¹
¹Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, ²Nephrology and Hypertension, Mayo Clinic, Phoenix, AZ, ³Transplant Surgery, Mayo Clinic, Phoenix, AZ, ⁴Cardiology, Mayo Clinic, Phoenix, AZ
*Purpose: This prospective study aims to assess the efficacy of preemptive therapy with eight days of a combination of direct-acting antivirals (DAAs) (Mavyret) (Pibrentasvir /Glecaprevir)…
2021 American Transplant Congress
Survival After Heart Transplant vs. Simultaneous Heart Kidney Transplant by Degrees of Renal Dysfunction at Engraftment in the United States: A Multivariable Analysis
S. M. Riad¹, M. Aljuhani¹, S. Jackson², T. Alexy¹, H. Wadie³, C. Martin¹, R. Kandaswamy⁴
¹Medicine, University of Minnesota, Eden Prairie, MN, ²Complex Care Analytics, Fairview Health Services, Minneapolis, MN, ³Transplant, Mayo Clinic, Jacksonville, FL, ⁴Surgery, University of Minnesota, Minneapolis, MN
*Purpose: There has been a rising trend for utilizing kidneys in heart transplant candidates with different renal dysfunction degrees without established criteria to address this…
2021 American Transplant Congress
High Interest, Low Payoff: Understanding Opportunities for Intervention for Those Exploring but Not Pursuing Paired Kidney Donation
A. D. Waterman¹, E. H. Wood¹, A. Thomas²
¹UCLA David Geffen School of Medicine, Los Angeles, CA, ²Johns Hopkins, Baltimore, MD
*Purpose: In 2016, the National Kidney Registry (NKR) established an online donor screening portal (DASH) to manage and track individuals interested in kidney paired donation…
2021 American Transplant Congress
Reduction in Medication Errors at Discharge in the Transplant Population via Use of Novel Pharmacist / Nursing Dual Check System
M. Norris, S. Witek, C. Whritenour, K. Sigafus, C. Chiang, C. Sammons, D. Naveiro, A. Paredes, E. Perez-Ngai, M. Kaminski, R. Westmoreland, G. Malat
Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Medication errors are of great concern due to the risk for patient and allograft injury. The aim of this study was to evaluate the…
2021 American Transplant Congress
Association Between Donor-Recipient Genetic Matching and Acute Rejection in Kidney Transplantation
R. Cao¹, V. Arthur², J. Chen², B. Keating², C. Dorr³, D. Schladt³, G. Onyeaghala³, R. Mannon⁴, A. Matas¹, R. Remmel¹, N. Pankratz¹, B. Wu¹, W. Oetting¹, P. Jacobson¹, A. Israni³, W. Guan¹
¹University of Minnesota, Minneapolis, MN, ²University of Pennsylvania, Philadelphia, PA, ³Hennepin Healthcare Research Institute, Minneapolis, MN, ⁴University of Nebraska, Omaha, NE
*Purpose: In this study we carried out a genome-wide association study (GWAS) between donor-recipient matching scores at individual SNP level and Acute rejection (AR) in…
2021 American Transplant Congress
Properties of Regulatory B Cells Suppressing B Cells
Q. Fu¹, K. Lee², K. Deng², G. Huai², C. Rickert², H. Yang¹, C. LeGuern², S. Deng¹, J. F. Markmann²
¹Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: Our previous study showed that TLR-Bregs, regulatory B cells generated in vitro through TLR activation, suppressed naïve B cell proliferation triggered by a mitogen…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
2021 American Transplant Congress
Treg Lymphotoxin Engages Lymphotoxin Receptor on Cancer and Endothelial Cells to Promote Cancer Metastatic Migration: Mechanisms for Treg-Cancer Interactions
W. Piao, R. Oakes, C. Paluskievicz, J. Christopher, J. Bromberg
U Maryland, Baltimore, MD
*Purpose: Treg immune suppression which is critical for transplant graft survival may also enhance tumor growth and metastases. Treg lymphotoxin (LTα1β2) may directly engage the…
2021 American Transplant Congress
IL-10 Signaling in T Cells Modulates Costimulation-independent Activation and is Essential for Transplant Tolerance Induction
M. Iglesias Lozano¹, D. Bibicheff¹, M. Chicco², A. Komin¹, G. Brandacher¹, G. Raimondi¹
¹Plastic Surgery, Johns Hopkins University, Baltimore, MD, ²Frimley Health NHS Foundation Trust, London, United Kingdom
*Purpose: Costimulation blockade (CoB)-based immunotherapy remains a very promising approach for better management of transplant recipients. Understanding the mechanisms that impact the efficacy of CoB…
2021 American Transplant Congress
Selective Bcl-2 Inhibition to Deplete Hematopoietic Stem Cells in Bone Marrow Niche: A Novel Approach to Promote Mixed Chimerism
T. Hirose¹, H. Sasaki¹, G. Lassiter¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, A. Cosimi¹, P. Cippa², T. Fehr², T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Institute of Physiology, University of Zurich, Zurich, Switzerland
*Purpose: A recent murine study has shown that successful mixed chimerism is achievable without myelosuppressive treatments by Bcl-2 inhibition. However, the mechanism by which selective…