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American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Management of Drug Interactions During Protocolized Implementation of Posaconazole Immediately Post Heart Transplant

    G. Waldman, C. Rogers Marks, J. Clark, A. Woo, L. Irwin, A. Gerlach, G. D. Lewis, J. A. Fishman

    Massachusetts General Hospital, Boston, MA

    *Purpose: Posaconazole (POSA) is a strong CYP3A4 inhibitor known to increase tacrolimus exposure by up to 4-fold. Initiation requires empiric tacrolimus dose adjustment and close…
  • 2021 American Transplant Congress

    Predicting Post-transplant Death and Graft Loss Risk: Insight at Listing

    N. Dzebisashvili1, M. Schnitzler2, K. Lentine2, K. Venkataramani1, S. Ghosh1

    1CareDx, Brisbane, CA, 2Saint Louis University, St. Louis, MO

    *Purpose: Prognostication models for post-transplant outcomes deriving inputs from information collected on donor (DDR/LDR), candidate (TCR) and transplant recipient (TRR) registrations can provide useful information…
  • 2021 American Transplant Congress

    Impact of COVID-19 on Solid Organ Transplantation

    E. Sampson1, S. Hall2, K. Robichaux3, A. Kumar2, N. Kemmer4, J. Buggs5

    1Lake Erie College of Osteopathic Medicine, Tampa, FL, 2Morsani College of Medicine, University of South Florida, Tampa, FL, 3Honors College, University of South Florida, Tampa, FL, 4Transplant Hepatology, Tampa General Hospital, Tampa, FL, 5Transplant Surgery, Tampa General Hospital, Tampa, FL

    *Purpose: Patterns of racial disparities have been identified throughout the history of American medicine. In December 2019, COVID-19 was first detected and has had a…
  • 2021 American Transplant Congress

    Kidney Transplantation Alone in Patients with Compensated Cirrhosis: A Multicenter Study

    A. Kassem1, S. Asrani1, S. W. Biggins2, Y. Darwish1, M. Nadim3, B. Fischbach1, T. Fong3

    1Baylor University Medical Center at Dallas, Dallas, TX, 2University of Washington, Seattle, WA, 3USC - Keck, Los Angeles, CA

    *Purpose: Patients undergoing kidney transplant (KTA) often have risk factors for liver disease including viral hepatitis and non-alcoholic fatty liver disease (NAFLD). Recent European Association…
  • 2021 American Transplant Congress

    De-novo Use Comparison Between Extended-release Once-daily Tacrolimus (Envarsus Xr®) and Immediate-release Twice-daily Tacrolimus (Prograf®) – A Single Center’s Experience

    N. Singh1, T. Le1, M. S. Naseer1, S. Asmil1, A. Palermini1, A. Qamar1, R. Chand1, S. Tandukar1, D. Aultman2, H. Shokouh-Amiri2, G. Zibari2

    1Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Medical Center, Shreveport, LA, 2Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Medical Center, Shreveport, LA

    *Purpose: Envarsus XR® is approved for de-novo use post-kidney transplantation at a higher starting dose (0.14mg/kg/day) as compared with Prograf® (0.1 mg/kg/day) despite better bioavailability.…
  • 2021 American Transplant Congress

    Mapping Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) in Kidney Transplant Biopsies Reveals Two Classes of Early AKI That Differ in Their Response-to-Wounding

    P. Halloran1, J. Reeve1, G. Böhmig2, O. Viklicky3, M. Myslak4, G. Gupta5, &. the INTERCOMEX Study Group6

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2Medical University of Vienna, Vienna, Austria, 3Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 4Pomeranian Medical University, Szczecin, Poland, 5Virginia Commonwealth University, Richmond, VA, 6., ., AB, Canada

    *Purpose: We recently analyzed injury-induced molecular changes in kidney transplant biopsies using principal component analysis (PCA) (AJT https://doi.org/10.1111/ajt.16374). PC1 reflected all injury, PC2 distinguished early…
  • 2021 American Transplant Congress

    Pregnancy Outcomes in 39 Lung Transplant Recipients

    S. Constantinescu1, L. A. Coscia2, A. Yusuf2, S. Rao3, M. J. Moritz4

    1Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 2Transplant Pregnancy Registry International, Philadelphia, PA, 3University of Virginia Heath System, Charlottesville, VA, 4Lehigh Valley Health Network, Allentown, PA

    *Purpose: The purpose of this study is to describe 52 pregnancies in 39 lung transplant recipients reporting to the Transplant Pregnancy Registry International (TPRI) from…
  • 2021 American Transplant Congress

    Tacrolimus Therapeutic Exposure is Not Consistently Predicted by Target Troughs or CYP3A5 Variants in Stable Renal Transplant Recipients

    K. Tornatore1, K. Attwood2, D. Brazeau3, B. Murray4

    1Pharmacy Practice, School of Pharmacy; University at Buffalo, Buffalo, NY, 2Biostatistics, School of Public Health; University at Buffalo, Buffalo, NY, 3Pharmacy Practice, School of Pharmacy; Marshall University, Huntington, WV, 4Medicine, Erie County Medical Center Corp., Buffalo, NY

    *Purpose: Tacrolimus (TAC) immunosuppression requires therapeutic trough monitoring post-transplant due to notable interpatient pharmacokinetic(PK) variability which may be attributed to CYP3A5 polymorphisms. We investigated the…
  • 2021 American Transplant Congress

    Overall Survival by Best Overall Response with Tabelecleucel in Patients with Epstein-Barr Virus-Driven Post-Transplant Lymphoproliferative Disease After Solid Organ Transplant

    S. Prockop1, L. Gamelin2, R. Dinavahi2, Y. Sun2, N. Guzman-Becerra2, H. Parmar2

    1Memorial Sloan Kettering Cancer Center, New York, NY, 2Atara Biotherapeutics, South San Francisco, CA

    *Purpose: Tabelecleucel is an investigational, off-the-shelf, allogeneic Epstein-Barr virus (EBV)-specific T-cell immunotherapy being studied in patients (pts) with serious EBV-driven diseases, including post-transplant lymphoproliferative disease…
  • 2021 American Transplant Congress

    Blood Type A2/a2b to B Renal Transplantation: A Single Center Retrospective Cohort Study

    V. S. Tatapudi, N. Alnazari, R. Chand, N. M. Ali, B. E. Lonze, R. A. Montgomery

    NYU Langone Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: Blood type B candidates on the deceased donor kidney waitlist have a lower transplantation rate and longer wait time than candidates of other blood…
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