2020 American Transplant Congress
Pregnancy Alloimmunization Increases the Clonality of the Endogenous Treg Repertoire
University of Pennsylvania, Philadelphia, PA
*Purpose: Pregnancy is a common immune sensitizing event, which creates an access barrier to organ transplantation and can impact transplant outcomes. While most research has…2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
1Starzl Transplantation Institute, Pittsburgh, PA, 2American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…2020 American Transplant Congress
Missing Self Increases the Incidence of Microvascular Inflammation after Kidney Transplantation
*Purpose: Anti-HLA donor-specific antibodies (HLA-DSA) are often absent in serum of kidney allograft recipients with biopsies demonstrating microvascular inflammation (MVI), the histological hallmark of antibody-mediated…2020 American Transplant Congress
Timing of Bariatric Surgery for Obese Liver Transplant Candidates
*Purpose: The timing of bariatric surgery for obese liver transplant candidates remains controversial. Surgery prior to transplant may improves one’s chance of receiving a transplant,…2020 American Transplant Congress
The Impact of Occult Graft Fibrosis on Clinical Outcomes in Human Liver Transplant Recipients
1UCLA, Los Angeles, CA, 2Kyoto University, Kyoto, Japan
*Purpose: Although liver transplantation (LT) has become a standard therapy for end-stage liver disease, early allograft dysfunction (EAD) and graft rejection remain serious unsolved problems.…2020 American Transplant Congress
A Stroke Volume-Based Fluid Resuscitation Protocol Decreases Vasopressor Support and Increases Organ Yield in Brain-Dead Donors
Mid-America Transplant, St Louis, MO
*Purpose: Brain-dead donors are frequently hypovolemic and hypotensive requiring vasopressor support. The goal of fluid resuscitation is to increase perfusion and oxygen delivery and avoid…2020 American Transplant Congress
Impact of Ozone Exposure of Lung Donors and Recipients on All-Cause Mortality after Lung Transplant
*Purpose: A Belgian study found proximity to a motorway increased risk of bronchiolitis obliterans syndrome after lung transplant (LT). Using zip codes as a surrogate…2020 American Transplant Congress
T and B Lymphocyte Dynamics after Genetically-Modified Pig-To-Baboon Kidney Xenotransplantation with an Anti-CD40mAb-Based Immunosuppressive Regimen
1Surgery, University of Alabama at birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA, VA
*Purpose: We have evaluated recovery of T and B lymphocytes and their subsets after depletion by anti-thymocyte globulin (ATG) and an anti-CD20mAb (Rituximab), followed by…
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