Am J Transplant, Volume 20, Suppl 3 Archives - Page 63 of 223 - ATC Abstracts

2020 American Transplant Congress
Textbook Outcome as a Composite Quality Metric in Kidney Transplantation
J. L. Han, A. J. Logan, J. M. Sneddon, G. L. Brock, K. W. Washburn, A. D. Schenk
Department of Surgery, Division of Transplantation, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Textbook outcomes (TO) describe ideal patient outcomes following specific surgical procedures and are useful composite quality metrics for patients, providers and payors. We aimed…
2020 American Transplant Congress
Muscle-Liver Crosstalk via the Myokine MG53 Plays a Critical Role in Hepatocellular Repair
C. Akateh, J. Ko, B. F. Reader, J. Kim, Y. Lee, B. A. Whitson, J. Ma, S. M. Black
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Transplantation remains the only effective treatment for end-stage liver disease, but the number of organs deemed suitable for transplantation falls far short of the…
2020 American Transplant Congress
Single-Cell RNA Sequencing to Assess the Effect of IL-6 Receptor Blockade in Kidney Transplantation
A. Zarinsefat, P. Rashmi, A. Da Silva, T. Sigdel, S. Chandran, Q. Tang, J. Ye, F. Vincenti, M. Sarwal
University of California San Francisco, San Francisco, CA
*Purpose: Prospective randomized study of IL-6R blockade with Tocilizumab for treatment of subclinical inflammation (SCI) in renal transplantation, reveals unique profiles of resting and stimulated…
2020 American Transplant Congress
Stability of T Reg with Combination of mTOR Inhibitors with Belatacept in Reducing Risk of Acute Rejection in Kidney Transplant
J. Shoji, J. Leung, Q. Tang, F. Vincenti
University of California San Francisco (UCSF), San Francisco, CA
*Purpose: Belatacept is a costimulatory blocker that is used as de novo maintenance immunosuppression in kidney transplantation to avoid toxic effects of calcineurin inhibitors and…
2020 American Transplant Congress
Clinical Significance of T Cell and B Cell Epitope Prediction as a Risk Factor of De Novo DSA Production after Kidney Transplantation
T. Kobayashi¹, K. Iwasaki¹, T. Tomosugi², Y. Miwa¹, M. Niemann³, E. Spierings⁴, K. Horimi¹, Y. Matsuoka¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³PIRCHE AG, Berlin, Germany, ⁴UMC Utrecht, Utrecht, Netherlands
*Purpose: Chronic antibody-mediated rejection caused by de novo DSA (dnDSA) is a major cause of graft failure. Risk prediction of dnDSA would be important for…
2020 American Transplant Congress
Predictors of Estimated GFR and Recurrent Chronic Kidney Disease (CKD) after Simultaneous Liver and Kidney Transplantation (SLKT): Results from the US Multicenter SKLT Consortium
P. Sharma¹, Z. Sui¹, M. Zhang¹, J. Magee¹, P. Barman², Y. Patel³, K. Walters⁴, S. Biggins⁵, A. Schluger⁶, G. Cullaro⁷, R. Wong⁸, J. Lai⁸, J. Jo⁹, J. Sinha⁹, L. VanWagner⁹, E. Verna⁷
¹Michigan Medicine, Ann Arbor, MI, ²UCSD, San Diego, CA, ³Duke, Durham, NC, ⁴UCLA, LA, CA, ⁵University of Washington, Seattle, WA, ⁶Westchester Medical Center, Weschester, NY, ⁷Columbia, New York, NY, ⁸UCSF, San Francisco, CA, ⁹Northwestern, Chicago, IL
*Purpose: SLKT is a life-saving intervention for patients with decompensated cirrhosis and concomitant end stage renal disease, irreversible acute kidney injury and select inherited metabolic…
2020 American Transplant Congress
Gut Commensal Microbiota are Associated with a Decreased Risk for Enterobacteriaceae Bacteriuria
J. R. Lee¹, M. Magruder¹, L. Zhang¹, D. Dadhania¹, E. Edusei¹, S. Albakry¹, M. Lubetzky¹, E. Pamer²
¹Medicine / Nephrology and Hypertension, Weill Cornell Medicine, New York, NY, ²University of Chicago, Chicago, IL
*Purpose: Uropathogens from the gut is thought to be a source of bacteriuria and urinary tract infection, but the role of gut commensal microbiota in…
2020 American Transplant Congress
Ethical Considerations and Post-Operative Outcomes in Good Samaritan Living Liver Donors: What Motivates Individuals to Donate to Strangers
C. Flaig, A. Humar, E. Kirschner, C. Hughes, S. Ganesh, A. Tevar, J. Steel
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Few transplant centers evaluate Good Samaritan living liver donors, secondary to ethical concerns and lack of evidence that the post-operative outcomes are comparable to…
2020 American Transplant Congress
Crispr-Based Diagnostics for Rejection and Opportunistic Infection Detection in Kidney Transplantation
I. T. Lape¹, M. M. Kaminski², E. Akalin³, J. Collins², L. W. Riella¹
¹Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA, ²Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, ³Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
*Purpose: There is an unmet need in transplantation to identify allograft injury non-invasively. More than 50% of patients with kidney transplants lose their grafts within…
2020 American Transplant Congress
Mitochondrion-Endothelial Interaction Generates Danger Signal in Promoting Costimulation-Resistant T Cell-Mediated Allograft Rejection
S. Li¹, M. Song¹, Q. Li², A. Kirk¹, H. Xu¹
¹Surgery, Duke University, Durham, NC, ²Immunology, Duke University, Durham, NC
*Purpose: Endothelial cells (ECs) play a critical role in allorecognition, presentation, and costimulation for initiation of alloimmune rejection. The objective of this study was to…