Am J Transplant, Volume 20, Suppl 3 Archives - Page 62 of 223 - ATC Abstracts

2020 American Transplant Congress
HLA Diversity Affects Epitope Mismatch Cutoffs Utilized to Predict De Novo DSA Development and Graft Rejection in Renal Transplant Patients
A. Ram¹, S. Dhingra², H. Quach¹, P. T. Jindra¹
¹Immune Evaluation Laboratory-Surgery, Baylor College of Medicine, Houston, TX, ²Pathology, Baylor College of Medicine, Houston, TX
*Purpose: Recent studies have investigated epitope matching in order to determine its predictive power in determining renal transplant outcomes, both in terms of de novo…
2020 American Transplant Congress
Allotransplantation of Ligated Arteriovenous Fistula as a Novel Strategy for Patients with Multiple Vascular Access Failures
M. A. Jaramillo-Gante¹, C. E. Acosta-Hernandez¹, P. R. Castro-Casillas¹, I. J. Linares-Cervantes²
¹Surgery, Star Medica Hospital, San Luis Potosi, Mexico, ²Surgery, University of Cincinnati Medical Center, Cincinnati, OH
*Purpose: To evaluate the feasibility of allotransplantation of a ligated arteriovenous fistula*Methods: We report the first case of allotransplantation of a mature working arterialized cephalic…
2020 American Transplant Congress
A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients
F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres
Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada
*Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
2020 American Transplant Congress
Automatic Quantification of Interstitial Fibrosis in Renal Allograft
J. Hogan¹, J. Vizcarra², M. A. Tageldin², L. A. Cooper³, D. A. Gutman², A. B. Farris⁴
¹Transplant Research Center, Department of Surgery, Emory University, Atlanta, GA, ²Computer Science Department, Emory University, Atlanta, GA, ³Pathology Department, Northwestern University, Evanston, IL, ⁴Pathology Department, Emory University, Atlanta, GA
*Purpose: Renal allografts are typically assessed by pathologists using the Banff classification with known interobserver variability. We previously demonstrated the utility of image analysis in…
2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
K. Carlson¹, F. Najmabadi¹, J. Pavan-Guimaraes¹, W. J. Burlingham¹, C. M. Capitini², D. P. Al-Adra¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
2020 American Transplant Congress
FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis
J. Zhang, J. Chen
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
2020 American Transplant Congress
The Effect of Ex Vivo Preservation and Regulatory T Cells on the Development of Transplant Arteriosclerosis in a Humanized Mouse Model
A. Knoefel, T. Siemeni, F. Ius, W. Sommer, J. Salman, I. Tudorache, A. Haverich, C. Falk, G. Warnecke
MHH, Hannover, Germany
*Purpose: Lung transplantation is the last remaining option for treatment of end stage lung disease. Explanted lungs can be preserved using ex vivo lung perfusion…
2020 American Transplant Congress
Cardiac Allograft Tolerance Can be Achieved in Non-Human Primates via Transient Mixed Hematopoietic Chimerism and Erythropoietin Administration
K. Ahrens¹, J. M. O¹, W. Sommer², J. Morrissette¹, D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan³, P. Cravedi⁴, P. S. Heeger⁴, G. Benichou¹, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁴Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: In non-human primates (NHPs), a mixed chimerism-based conditioning protocol results in kidney transplant tolerance and combined kidney and heart allograft tolerance. Previous work showed…
2020 American Transplant Congress
A Video Education Intervention to Improve Kidney Transplant Knowledge and Self-Efficacy in Dialysis Center End Stage Renal Disease (ESRD) Patients
D. A. DuBay¹, T. Morinelli¹, Z. Sutton¹, M. Chastain¹, T. Thompkins Tindal¹, Z. Su¹, E. Weeda¹, P. Mauldin¹, M. Casey¹, J. Bian¹, J. Rodrigue², P. Baliga¹, D. Taber³
¹Medical University of South Carolina`, Charleston, SC, ²Departments of Surgery and Psychiatry, Beth Israel Deaconiess Medical Center, Boston, MA, ³Department of Surgery, Medical University of South Carolina`, Charleston, SC
*Purpose: Only 34% of incident ESRD patients are referred for transplant (Tx) evaluation within 12 months of initiating dialysis. There is great need for effective…
2020 American Transplant Congress
The Eplet-Mismatch Landscape in Kidney Patients and Deceased Donors in British Columbia
J. Tran¹, O. Gunther², J. Lan¹, M. Kadatz¹, R. Sapir-Pichhadze³, P. A. Keown¹
¹University of British Columbia, Vancouver, BC, Canada, ²Gunther Analytics, Vancouver, BC, Canada, ³McGill University, Montreal, QC, Canada
*Purpose: Minimizing quantitative donor/recipient mismatch at the HLA epitope level may optimize graft outcomes in renal transplantation, but the degree to which optimal matching can…