Am J Transplant, Volume 20, Suppl 3 Archives - Page 57 of 223 - ATC Abstracts

2020 American Transplant Congress
The Effect of B Cell Depletion Therapies on Preformed Xenoantibodies in Transplant Recipient
S. Yeh¹, N. A. Wilson², A. Djamali², R. Redfield³
¹Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, ²Medicine/Nephrology, University of Wisconsin-Madison, Madison, WI, ³Surgery, University of Wisconsin-Madison, Madison, WI
*Purpose: To assess the effect of B cell depletion therapies on preformed xenoantibodies in transplant recipient. Preformed xenoantibodies are a significant barrier to successful xenotransplantation.…
2020 American Transplant Congress
The Effect of Human Thrombomodulin on Thrombotic Complications in Life Supporting Pig-to-Baboon Cardiac Xenotransplantation
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, D. Ayares², M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
Pediatric Renal Transplant after Intestinal Transplant – Technical Challenges and Outcomes
A. Amin, B. Emmanuel, Y. Chang, G. Bond, A. Khanna, K. Soltys, R. Sindhi, A. Tevar, A. Humar, G. Mazariegos, A. Ganoza
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: There is no data in the literature about outcomes of pediatric intestinal transplant (IT) recipients, who require renal transplant after intestinal transplant (RTAIT). The…
2020 American Transplant Congress
Donor-Derived Cell-Free DNA Combined with Histology Improves Prediction of eGFR Decline in Kidney Transplant Recipients over Histology Alone
M. Gillespie, M. Haas, K. Lim, A. Vo, A. Peng, R. Najjar, S. Sethi, S. Jordan, E. Huang
Cedars-Sinai, Los Angeles, CA
*Purpose: Higher Banff inflammation and chronicity scores on kidney transplant (KTx) biopsies (Bx) have been associated with poorer graft survival, but Bx scores alone imperfectly…
2020 American Transplant Congress
Hif-1a Expression Influences Recipient Clinical Outcomes in Liver Transplant Patients
K. Kadono, T. Ito, H. Kojima, K. Nakamura, H. Hirao, S. Kageyama, K. J. Dery, A. Murray, R. W. Busutill, F. Kaldas, J. W. Kupiec-Weglinski
Liver Transplant Surgery, UCLA, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury (IRI), an innate-immune dominated hepatocellular damage, is a risk factor for early allograft dysfunction (EAD) and rejection crises in liver transplantation…
2020 American Transplant Congress
T-cell Receptor Deep Sequencing to Distinguish Autoimmune Recurrence from Allograft Rejection in Liver Transplant Patients with Autoimmune Liver Disease
K. J. Yang¹, M. Martinez², B. Shonts¹, C. A. Parks¹, A. Z. Obradovic¹, T. M. Savage¹, E. Spyrou¹, S. Lau¹, M. I. Colquhoun¹, K. Rodgers¹, E. Verna³, S. M. Coley⁴, S. Yang¹, Y. Shen⁵, M. Sykes¹
¹Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Department of Medicine, Columbia University, New York, NY, ⁴Department of Pathology, Columbia University, New York, NY, ⁵Center for Computational Biology & Bioinformatics, Department of Systems Biology, Columbia University, New York, NY
*Purpose: Patients who undergo liver transplantation for autoimmune liver disease (ALD) experience high rates of graft failure. The relative roles of recurrent ALD and rejection…
2020 American Transplant Congress
Belatacept Combined with BTLA Prolong Allogeneic Kidney Graft Survival and Inhibited Acute Rejection after Kidney Transplantation
H. Zhang, Z. Wang, J. Zhang, Z. Han, J. Tao, H. Chen, L. Sun, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Belatacept as a high-affinity variant of CTLA-4Ig, has been applied into kidney transplantation to against acute rejection. However, adoption of Belatacept has been limited…
2020 American Transplant Congress
Real-Time Viability Assessment During Normothermic Machine Perfusion with Resonance Raman Spectroscopy
R. J. De Vries¹, S. Raigani¹, P. Romfh², S. E. Cronin¹, C. A. Pendexter¹, C. Carroll¹, T. M. Van Gulik³, P. Chen², K. Uygun¹, H. Yeh¹, S. N. Tessier¹
¹Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Pendar Technologies, Cambridge, MA, ³Surgery, Amsterdam University Medidical Centers, Location AMC, Amsterdam, Netherlands
*Purpose: Viability assessment during normothermic machine perfusion (NMP) continues to lack objective metrics that facilitate accurate clinical decision making, in order to minimize discard rates…
2020 American Transplant Congress
Humoral Sensitization Overrides Pregnancy-Induced T Cell Transplantation Tolerance
D. Tran¹, A. Suah¹, S. Khiew¹, J. Young¹, M. Andrade¹, J. Pollard¹, Q. Wang¹, D. Yin¹, G. Chalasani², M. Alegre¹, A. Chong¹
¹Department of General Surgery, University of Chicago, Chicago, IL, ²Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: There are ample clinical data that a major long-term consequence of pregnancy is humoral allosensitization. Paradoxically, pregnancy is also a state of spontaneous allogeneic…
2020 American Transplant Congress
Long Term Outcomes of Hypertensive Kidney Donors
H. Ibrahim, S. Hebert, H. E. Adrogue, D. T. Nguyen, E. A. Graviss, A. Gaber, A. Matas
Houston Methodist Hospital, Houston, TX
*Purpose: Many people with hypertension are excluded from kidney donation fearing that hypertension is a major cause of CKD and its impact maybe magnified after…