Am J Transplant, Volume 20, Suppl 3 Archives - Page 55 of 223 - ATC Abstracts

2020 American Transplant Congress
Introducing the Smartphone App, EL-FIT (Exercise & Liver FITness), to Help Monitor and Prehabilitate Liver Transplant Candidates
A. Duarte-Rojo¹, P. M. Bloomer¹, R. J. Rogers², M. A. Dunn¹, E. B. Tapper³, R. Bataller¹, C. B. Hughes¹, A. A. Ferrando¹, W. R. Kim⁴, J. M. Jakicic²
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³University of Michigan, Ann Arbor, MI, ⁴Stanford University, Palo Alto, CA
*Purpose: Physical activity is key to liver transplant (LT) prehabilitation, and leveraging technologies to monitor physical performance and to generalize training may be advantageous. EL-FIT…
2020 American Transplant Congress
Effectiveness of Bezlotoxumab for Prevention of Recurrent Clostridioides Difficile Infection among Transplant Recipients
V. Bajrovic¹, T. Johnson², A. Howard², L. Allen³, G. Barber², K. Schwarz², M. Huang³, M. Abidi¹, E. Benamu³, P. Ramanan³, M. Miller⁴
¹Division of Infectious Diseases, University of Colorado, Denver, CO, ²Department of Pharmacy, University of Colorado, Aurora, CO, ³Division of Infectious Diseases, University of Colorado, Aurora, CO, ⁴Department of Pharmacy, University of Colorado, Denver, CO
*Purpose: Clostridioides difficile is an urgent health threat associated with significant morbidity and mortality. Recipients of solid organ (SOT) and hematopoietic-cell transplantations (HCT) are at…
2020 American Transplant Congress
Divergent Molecular Pathways Underlie the Evolution of Allograft Fibrosis in Two Mouse Models of Chronic Lung Allograft Dysfunction
T. Watanabe, J. Allen, K. Boonstra, Z. Guan, K. Bei, S. Keshavjee, J. Yeung, T. Martinu, S. Juvet
Latner Thoracic Surgery Research Laboratories, Toronto Lung Transplant Program / University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is potentiated by activation of the innate immune system and occurs in two patterns: diffuse…
2020 American Transplant Congress
Overcoming Ab-Mediated Xenolung Rejection: Beta4Gal is an Important Pre- and Post-Transplant Ab Target, Relevant to Xenograft Injury in Baboons
L. Burdorf¹, Z. Abady¹, B. Cerel¹, K. Petitpas¹, C. Laird², S. Pratts¹, X. Cheng², C. J. Phelps³, W. Eyestone³, D. L. Ayares³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Surgery, University of Maryland, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: Knock-out (KO) of porcine carbohydrates (CHO), including Gal 1,3αGal, inhibits antibody-mediated xenograft rejection. The β4Gal epitope was discovered using serum from xenograft-sensitized baboons, but…
2020 American Transplant Congress
Belatacept-Based, Calcineurin Inhibitor and Corticosteroid Free Immunosuppression: Differential Outcomes Based on Recipient Age
N. Wilson¹, A. R. Shields², D. Kaufman³, A. Wiseman⁴, A. L. Christianson¹, S. Tremblay¹, J. P. Leone⁵, A. J. Matas⁶, P. West-Thielke⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Wisconsin, Madison, WI, ⁴U Colorado, Denver, CO, ⁵Tampa General, Tampa, FL, ⁶U Minnesota, Minneapolis, MN, ⁷U Illinois Chicago, Chicago, IL
*Purpose: Age-based disparities have been described in calcineurin inhibitor (CNI)-based immunosuppression regimens, but are not well-described for belatacept (BELA)-based regimens. This study analyzed the effect…
2020 American Transplant Congress
Timing of Bariatric Surgery for Obese Kidney Transplant Candidates
R. A. Choudhury¹, D. Yoeli¹, G. Hoeltzel², H. B. Moore¹, H. Yaffe¹, K. R. Dumon³, N. N. Williams³, P. L. Abt⁴, K. D. Conzen¹, T. Pshak¹, P. T. Kennealey¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³Department of Surgery, University of Pennsylvania Hospital, Philadelphia, PA, ⁴Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA
*Purpose: The high risk profile of bariatric surgery in obese end-stage-renal disease (ESRD) patients has caused many to suggest that surgery should be reserved for…
2020 American Transplant Congress
Effects of Mandatory 6-Month Waiting Time Policy on Post-Transplant Outcomes and Explant Pathology in Liver Transplant Patients with Hepatocellular Carcinoma
S. Nagai, T. Kitajima, S. Yeddula, R. Salgia, M. Abouljoud, D. Moonka
Henry Ford Hospital, Detroit, MI
*Purpose: In the United States, current allocation policy mandates a 6-month waiting period before exception scores are granted to liver transplant (LT) candidates with hepatocellular…
2020 American Transplant Congress
American Muslims & Informed Organ Donation Decisions: Findings from a Randomized, Controlled Trial of Religiously-Tailored Education in Mosques
A. I. Padela¹, R. Duivenbode², M. Quinn¹, M. Craig³, M. Saunders¹
¹Department of Medicine, The University of Chicago, Chicago, IL, ²Initiative on Islam and Medicine, The University of Chicago, Chicago, IL, ³The National Kidney Foundation Illinois, Chicago, IL
*Purpose: American Muslims hold more negative attitudes towards organ donation than other American populations, and these attitudes are associated with gaps in biomedical and religious…
2020 American Transplant Congress
Outcomes of Hiv-Positive Patients Post-Cardiac Transplantation
G. S. Liu¹, A. M. Wolfson², A. D. Salimbangon³, R. R. Chand⁴, P. Banankhah¹, J. Nattiv¹, P. A. Genyk¹, P. A. Kingsford¹, J. P. Li¹, D. Vucicevic⁵, K. Pandya¹, J. Rahman¹, M. Fong¹, E. C. DePasquale¹, A. S. Vaidya¹
¹Keck Medicine of USC, Los Angeles, CA, ²University of Arizona Sarver Heart Center, Tucson, AZ, ³UCLA Medical Center, Los Angeles, CA, ⁴Harbor-UCLA Medical Center, Los Angeles, CA, ⁵Newark Beth-Israel Medical Center, Newark, NJ
*Purpose: Human immunodeficiency virus (HIV) infection is no longer an absolute contraindication to heart transplantation (HT) in many HT centers, but long-term post-HT outcomes of…
2020 American Transplant Congress
Kidney Alkalization Increases Macula Densa NOS1β Expression and Improves Transplanted Renal Graft Function
J. Buggs¹, J. Zhang², J. Wei², L. Wang²
¹Transplant Surgery, Tampa General Hospital, Tampa, FL, ²Molecular Pharmacology & Physiology, University of South Florida, Morsani College of Medicine, Tampa, FL
*Purpose: Ischemia-reperfusion injury (IRI) is a major survival hurdle with kidney transplantation (KTX). Currently, no effective strategies for the prevention and treatment of IRI during…