2020 American Transplant Congress
Single Cell RNA Sequencing of Murine Kidney Allografts Identifies Macrophage Gene Signature Associated with Acute Rejection
*Purpose: Evaluating kidney allografts using single cell RNA sequencing (scRNAseq) can provide a comprehensive qualitative and quantitative gene expression data on thousands of individual cells.…2020 American Transplant Congress
Anti-CD321 Antibody (90G4) Protects Liver against Ischemia Reperfusion Injury in a Murine Model
*Purpose: Ischemia reperfusion results in increased transmigration of leukocytes into tissue. This eventually leads to post transplant graft damage after organ transplantation. CD321 (also known…2020 American Transplant Congress
IL-10 Exposure Enhances IRAK-M Expression to Promote Endotoxin Tolerance and the T Cell Tolerogenic Potential of Liver Conventional DCs
Surgery, Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Liver conventional myeloid (m)DC contribute to liver transplant tolerance. When freshly-isolated, they produce low levels of IL-12 but high levels of IL-10 compared with…2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…2020 American Transplant Congress
High PRA Increases Rejection but Does Not Worsen Renal Function in the First Year Post Kidney Transplant with Alemtuzumab Induction
Ochsner Medical Center, New Orleans, LA
*Purpose: Sensitization is an important immunologic risk factor considered in renal allograft allocation and influences immunosuppression. Unfortunately, there is a lack of consensus regarding the…2020 American Transplant Congress
Long-Term Outcomes of Single Kidney Transplants from Small Pediatric Donors
Weill Cornell Medical College, New York, NY
*Purpose: On September 5th, 2019, UNOS implemented an important policy change in the allocation of kidneys from small pediatric donors. In trying to balance achieving…2020 American Transplant Congress
Prevalence of Primary Aldosteronism in Kidney Transplant Recipients: A Cross-Sectional Study
University of Wisconsin-Madison, Madison, WI
*Purpose: The prevalence of primary aldosteronism (PA) in the general hypertensive (HTN) population is more than 5%, and substantially higher at 20% in certain high-risk…2020 American Transplant Congress
Comparison of Intraoperative Cortical Renal Blood Flow after Reperfusion Using Laser Speckle Flowgraphy Device between Adult and Pediatric Kidney Transplants
Nephrology, Toho University Faculty of Medicine, Tokyo, Japan
*Purpose: Laser speckle flowgraphy (LSFG) is a device to monitor cutaneous and ocular fundus blood flow. The aim of this study reveals that the differences…2020 American Transplant Congress
Calcium Phosphate Crystals: An Under Recognized Cause of Kidney Allograft Injury?
Vanderbilt University Medical Center, Nashville, TN
*Purpose: Calcium phosphate (CaPhos) crystals are a known cause of dysfunction in native kidneys. Our objectives were to describe the incidence of CaPhos crystal deposition…2020 American Transplant Congress
Glomerular C4d in Post-Transplant IgA Glomerulonephritis is Associated with Decreased Allograft Survival
Medical University of Vienna, Vienna, Austria
*Purpose: Post transplant (pTX) glomerulonephritis (GN) is an important factor contributing to early and late allograft failure. De novo or recurrent IgA GN are the…
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