ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation

    L. Fan1, X. Zhang1, T. Li1, L. R. Mathews1, G. K. Dwyer2, M. J. Calderon3, K. E. Helfrich3, M. A. Ross3, S. C. Watkins3, H. R. Turnquist1

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Immunology, University of Pittsburgh, Pittsburgh, PA, 3Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Chronic rejection (CR) after organ transplantation (Tx) manifests as function-limiting allograft fibrosis and vasculopathy. Current immunosuppressants fail to prevent CR and insights into the…
  • 2020 American Transplant Congress

    Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion

    Y. Kim1, K. Kim1, J. Lee1, J. Moon1, J. Kim1, J. Lee2, Y. Kim1, S. Yang1

    1Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 2Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of

    *Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
  • 2020 American Transplant Congress

    Poly (ADP-Ribose) Polymerase Inhibitor Treatment Attenuated Renal Ischemia-Reperfusion Injury

    H. Jang, K. Lee, J. Jeon, J. Lee, Y. Kim, D. Kim, W. Huh

    Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of

    *Purpose: Robust intrarenal inflammatory responses following ischemia-reperfusion injury (IRI) induce renal injury in ischemic acute kidney injury (AKI). We hypothesized that poly (ADP-Ribose) polymerase (PARP)…
  • 2020 American Transplant Congress

    2-Year Results of a Naturalistic Study of De Novo Extended-Release Tacrolimus Tablets vs. Tacrolimus Immediate-Release Capsules in Kidney Transplant Recipients

    J. Hagopian1, S. January1, N. Nesselhauf1, K. Progar1, T. Horwedel2, R. Delos Santos3

    1Barnes-Jewish Hospital, Saint Louis, MO, 2Veloxis Pharmaceuticals, Cary, NC, 3Washington University, Saint Louis, MO

    *Purpose: In December 2015, our center instituted a protocol change moving to de novo use of tacrolimus-XR (LCPT). The objective of this extension study is…
  • 2020 American Transplant Congress

    Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation: A Prospective Analysis Across Two Years

    J. M. Rohan1, J. Leone2, E. Woodle3, D. Kaufman4, A. Shields5, A. Wiseman6, A. Matas7, P. West-Thielke8, E. King5, R. Alloway3

    1Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, 2Tampa General, Tampa, FL, 3University of Cincinnati, Cincinnati, OH, 4U Wisconsin, Madison, WI, 5U Cincinnati, Cincinnati, OH, 6U Colorado, Denver, CO, 7U Minnesota, Minneapolis, MN, 8UIC, Chicago, IL

    *Purpose: Previous trials have not examined 2-year longitudinal differences in patient-reported outcomes (PRO) between belatacept (BELA)- and tacrolimus (TAC)-based therapies in adult kidney transplant (KTx)…
  • 2020 American Transplant Congress

    Survival Benefit of Accepting Kidneys from Older Donation after Cardiac Death Donors

    S. Yu, J. Long, Y. Yu, M. Bowring, J. Motter, T. Ishaque, D. Segev, J. Garonzik-Wang, A. Massie

    Johns Hopkins, Baltimore, MD

    *Purpose: Kidneys from older donation after cardiac death (DCD) donors are less likely to be transplanted due to concerns about inferior post-transplant survival. But candidates…
  • 2020 American Transplant Congress

    Deceased Donors in Kidney Paired Donation

    J. D. Kalbfleisch1, W. Wang1, M. A. Rees2, A. B. Leichtman3, P. X. Song1, V. Ashby1, T. Shearon1

    1Biostatistics, University of Michigan, Ann Arbor, MI, 2University of Toledo, Toledo, OH, 3University of Michigan, Ann Arbor, MI

    *Purpose: A kidney paired donation pool (KPDP) consists of transplant candidates and their incompatible living donors along with nondirected living donors (NDDs). In a match…
  • 2020 American Transplant Congress

    Widespread Deregulation of Metabolic Genes in Steatotic Livers Pre- And Post-Transplantation

    A. R. Wolen1, C. Kuscu2, C. Kuscu2, A. Bajwa2, J. Eason2, S. Sataphaty3, J. D. Eason1, D. Maluf1, V. Mas1

    1Department of Surgery_ University of Tennessee, James D Eason Transplant Institute, Memphis, TN, 2Department of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, 3Sandra Atlas Bass Center for Liver Diseases & Transplantation, Northshore University Hospital/Northwell Health, NYC, NY

    *Purpose: The escalating obesity crisis is a double-edged sword for the field of liver transplantation; higher rates of fatty liver disease increase both the demand…
  • 2020 American Transplant Congress

    Comparative Analysis of Kidney Transplant-Specific versus Hospital-Wide Antibiograms

    J. D. Lewis

    Medical University of South Carolina, Charleston, SC

    *Purpose: Solid organ transplant (SOT) recipients are more likely to develop antimicrobial-resistant infections versus the general population, but few transplant centers have developed SOT-specific antibiograms…
  • 2020 American Transplant Congress

    C-Reactive Protein 1-Year Post-Transplant is Associated with Future Development of Coronary Artery Vasculopathy and Rejection in a Pediatric Heart Transplant Cohort

    H. J. Tadros, A. H. Bashir, F. J. Fricker, B. A. Pietra, D. Gupta

    Congenital Heart Center/Pediatrics, University of Florida, Gainesville, FL

    *Purpose: Coronary artery vasculopathy (CAV) is one of the leading causes of mortality beyond 3y post-transplant (OHT). Multiple risk factors are associated with development of…
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