ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation: A Prospective Analysis Across Two Years

J. M. Rohan1, J. Leone2, E. Woodle3, D. Kaufman4, A. Shields5, A. Wiseman6, A. Matas7, P. West-Thielke8, E. King5, R. Alloway3

1Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, 2Tampa General, Tampa, FL, 3University of Cincinnati, Cincinnati, OH, 4U Wisconsin, Madison, WI, 5U Cincinnati, Cincinnati, OH, 6U Colorado, Denver, CO, 7U Minnesota, Minneapolis, MN, 8UIC, Chicago, IL

Meeting: 2020 American Transplant Congress

Abstract number: 220

Keywords: Kidney transplantation, Psychiatric comorbidity, Psychosocial, Quality of life

Session Information

Date: Sunday, May 31, 2020

Session Name: Plenary Session II

Session Time: 9:59am-10:40am

 Presentation Time: 10:00am-10:07am

Location: Main Channel

Related Abstracts
  • Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation
  • A Prospective Randomized Multicenter Trial (BEST Trial) of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression: Infectious Complications

*Purpose: Previous trials have not examined 2-year longitudinal differences in patient-reported outcomes (PRO) between belatacept (BELA)- and tacrolimus (TAC)-based therapies in adult kidney transplant (KTx) patients (pts). The BEST Trial (Belatacept-based Early Steroid-withdrawal Trial) was designed to compare 2 BELA-based early steroid withdrawal (ESW) regimens with a TAC-based ESW regimen across 2 years. Our hypothesis was that patients on BELA will have fewer immunosuppressant-related symptoms and improved quality of life (QoL).

*Methods: This longitudinal, multisite study was conducted under an FDA IND and IRB across 8 sites. All pts received mycophenolate therapy and 5 days of steroids. Pts were randomized to 3 groups: alem+BELA, r-ATG+BELA, r-ATG+TAC. Pts completed 2 PRO measures at baseline, 1-year, and 2-years (MEMPHIS, MTSOSD-59R).

*Results: Intent to treat analyses on 138 pts with 2-year follow-up were completed. Those on BELA-based therapies generally reported higher gains in QoL across 2-years; and, reported lower probability of adverse events at 2-years. No significant differences were observed between groups for total QoL, misc side effects, GI distress, emotional burden, life responsibilities, or mobility. Alem+BELA and r-ATG+BELA groups were compared to r-ATG+TAC group at 2-years and differences in individual symptom scores were observed.

*Conclusions: CNI free/ESW Bela-based regimens resulted in a tendency toward improved PROs across 2-years. All baseline symptoms improved with transplant except GI distress in the TAC-based regimen, which increased at 2-years. Neurologic, GI, and mobility symptoms were reported less frequently in the BELA-based regimens. Psychological symptoms (e.g., restlessness, anxiety, mood changes) were higher in bela-based regimens relative to TAC-based regimens. Sores on lips and warts on hands/feet were more frequently observed in bela-based regimens at 2-years, which may be related to increased viral infections. Bela-based regimens continued to have a decreased risk of trembling hands relative to TAC-based regimens. Table 1. Comparison of Symptom Scores by Treatment Group at 2 years

 border=

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Rohan JM, Leone J, Woodle E, Kaufman D, Shields A, Wiseman A, Matas A, West-Thielke P, King E, Alloway R. Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation: A Prospective Analysis Across Two Years [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/patient-reported-outcomes-in-a-prospective-multicenter-trial-of-belatacept-based-cni-and-corticosteroid-free-immunosuppression-regimens-in-kidney-transplantation-a-prospective-analysis-across-two-ye/. Accessed March 8, 2021.

« Back to 2020 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Home
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Search
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Home
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.