Am J Transplant, Volume 20, Suppl 3 Archives - Page 29 of 223 - ATC Abstracts

2020 American Transplant Congress
Identification of Novel Gene Targets Inducing Resistance in Liver Ischemia Reperfusion Injury by CRISPR Screening
C. Kuscu, A. R. Wolen, C. Kuscu, C. Watkins, A. Bajwa, J. D. Eason, D. Maluf, V. Mas
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Liver transplantation (LT) is the best treatment option for patients with end-stage liver disease (ESLD). However, the gap between available donors and recipients in…
2020 American Transplant Congress
Autophagy-Lysosome Inhibitor Chloroquine Prevents CTLA-4 Degradation of T Cells and Attenuates Acute Rejection in Murine Skin and Heart Transplantation
J. Wu
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: The immune checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4), which was induced upon T cell activation but degraded quickly, has been targeted in the clinical…
2020 American Transplant Congress
Steroid Withdrawal and Lymphocyte Subsets in Graft Capillary Blood versus Peripheral Blood in Low Immunological Risk Kidney Transplant Patients: Randomized, Parallel Group, Controlled Clinical Trial
T. Vazquez Sanchez, A. Caballero, J. Alonso-Titos, V. Lopez, E. Sola, M. Cabello, E. Gutierrez Vilchez, M. Martínez-Esteban, P. Ruiz Esteban, J. Delgado, D. Hernandez
Regional University Hospital, Malaga, Spain
*Purpose: Whether steroid withdrawal can modulate the subclinical inflammatory response after a kidney transplant is unknown.*Methods: We undertook a controlled multicenter clinical trial involving 105…
2020 American Transplant Congress
Three-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection – Early Impact of Interleukin-6 Blockade on Donor-Specific Antibody Levels, Rejection Morphology and Gene Expression
G. A. Böhmig¹, M. Dürr², B. Jilma³, F. Eskandary¹, E. Chong⁴, S. Schranz³, K. Doberer¹, M. Wahrmann¹, A. Borski¹, H. Regele⁵, J. Kläger⁵, R. Reindl-Schwaighofer¹, J. Reeve⁶, K. Budde², P. F. Halloran⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Nephrology Department, Charité Berlin, Berlin, Germany, ³Dept. of Clin. Pharmacology, Medical University of Vienna, Vienna, Austria, ⁴Vitaeris Inc., Vancouver, BC, Canada, ⁵Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, ⁶Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Targeting Interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). This phase 2 trial (NCT03444103) was designed to evaluate the safety and…
2020 American Transplant Congress
Does Choice of Inferior Vena Cava Reconstruction Technique Have an Impact on the Short and Long Term Postoperative Renal Function in Liver Transplant Recipient?
S. Chartier-Plante¹, S. Asrani², J. Bayer², H. Fernandez², A. Gupta², E. Martinez², G. J. Mckenna², N. Onaca², N. Onaca², R. M. Ruiz², G. Saracino², A. Wall², G. Testa²
¹Vancouver General Hospital, Vancouver, BC, Canada, ²Baylor University Medical Center, Dallas, TX
*Purpose: Postoperative acute kidney injury (AKI) is common after liver transplant (Oltx). It is associated with increased morbidity and mortality and is a risk factor…
2020 American Transplant Congress
Impact of Frailty on Early and Late Hospital Readmission after Kidney Transplantation
H. Hendra¹, B. Sandhu², E. Frackiewicz², G. Jones², P. Masson², R. Motallebzadeh³
¹Centre for Transplantation, Department of Renal Medicine, University College London & Royal Free London NHS Foundation Trust, London, United Kingdom, ²Royal Free Hospital, London, United Kingdom, ³Centre for Transplantation, University College London & Royal Free London NHS Foundation Trust, London, United Kingdom
*Purpose: Currently there are no tools to predict outcomes after kidney transplantation (KTx). This study assesses whether frailty influences post-KTx complications. Understanding frailty and its…
2020 American Transplant Congress
Effect of DSA-Free Heart Allocation
V. Patel¹, M. Skeans², T. Cascino¹, R. Davies³, M. Colvin¹
¹University of Michigan, Ann Arbor, MI, ²SRTR, Minneapolis, MN, ³UT Southwestern, Dallas, TX
*Purpose: Currently, donation service area (DSA) is the first geographic unit for heart allocation, which creates discrepancies in access for high-urgency candidates. We studied the…
2020 American Transplant Congress
Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion
P. Cravedi, M. Fribourg, S. Harztell, L. Anderson, P. Heeger
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…
2020 American Transplant Congress
Age-Enhanced Transplant Vasculopathy Associates with Impaired Vascular Mitophagy
M. Blin¹, D. Tyrrell¹, S. Wood¹, D. Farris¹, S. G. Tullius², D. R. Goldstein¹
¹Micro and Immunology/Internal Medicine, University of Michigan, Ann Arbor, MI, ²Transplant Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Donor aging leads to increased chronic allograft vasculopathy (CAV) for unclear reasons. Here, we investigated whether impaired alterations in mitophagy, a mechanism to remove…
2020 American Transplant Congress
Significant Improvement in Short and Long-Term Kidney Transplant Survival Despite Stagnant Rates of Delayed Graft Function
J. Schold¹, S. Arrigain², E. Poggio³
¹Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ³Nephrology, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Delayed Graft Function (DGF) is routinely characterized as attributing to significant morbidity and mortality among kidney transplant recipients. While there are diverse potential mechanisms…